Zobrazeno 1 - 10
of 118
pro vyhledávání: '"MARINELLA ROBERTI"'
Autor:
Federica Bruno, Germano Castelli, Fabrizio Vitale, Simone Catanzaro, Valeria Vitale Badaco, Marinella Roberti, Claudia Colomba, Antonio Cascio, Manlio Tolomeo
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1199 (2021)
Background: Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite Trypanosoma cruzi. No progress in the treatment of this pathology has been made since Nifurtimox was introd
Externí odkaz:
https://doaj.org/article/f109cc353b264baeb1e25cb6954298ae
Autor:
Fabrizio Vetica, Anna Sansone, Cesare Meliota, Gessica Batani, Marinella Roberti, Chryssostomos Chatgilialoglu, Carla Ferreri
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1189 (2020)
Free-radical-mediated processes, such as peroxidation, isomerization and hydrogenation affecting fatty acid integrity and biological functions, have a trans-disciplinary relevance. Cardiolipins (CL, (1,3-diphosphatidyl-sn-glycerol)) and tetra-linoleo
Externí odkaz:
https://doaj.org/article/6cf959e130904919bcf5e97010819d36
Autor:
Silvia Turroni, Manlio Tolomeo, Gianfranco Mamone, Gianluca Picariello, Elisa Giacomini, Patrizia Brigidi, Marinella Roberti, Stefania Grimaudo, Rosaria Maria Pipitone, Antonietta Di Cristina, Maurizio Recanatini
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57650 (2013)
Over the past years, we synthesized a series of new molecules that are hybrids of spirocyclic ketones as complexity-bearing cores with bi- and ter-phenyls as privileged fragments. Some of these newly-shaped small molecules showed antiproliferative, p
Externí odkaz:
https://doaj.org/article/b76cc932812d42ea870d87bb3dbdbae9
Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry
Autor:
Greta Bagnolini, Beatrice Balboni, Fabrizio Schipani, Dario Gioia, Marina Veronesi, Francesca De Franco, Cansu Kaya, Ravindra P. Jumde, Jose Antonio Ortega, Stefania Girotto, Anna K. H. Hirsch, Marinella Roberti, Andrea Cavalli
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1262-1269
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1cd8316dc4e898e25a3bb0386df22c
https://doi.org/10.1021/acsmedchemlett.2c00063
https://doi.org/10.1021/acsmedchemlett.2c00063
Autor:
Fabrizio Schipani, Marcella Manerba, Roberto Marotta, Laura Poppi, Arianna Gennari, Francesco Rinaldi, Andrea Armirotti, Fulvia Farabegoli, Marinella Roberti, Giuseppina Di Stefano, Walter Rocchia, Stefania Girotto, Nicola Tirelli, Andrea Cavalli
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8338
The cytotoxic action of anticancer drugs can be potentiated by inhibiting DNA repair mechanisms. RAD51 is a crucial protein for genomic stability due to its critical role in the homologous recombination (HR) pathway. BRCA2 assists RAD51 fibrillation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ae509a43fc7be971237b00e4b5c0e3
https://pubmed.ncbi.nlm.nih.gov/35955488
https://pubmed.ncbi.nlm.nih.gov/35955488
Autor:
Isabella Pallavicini, Greta Bagnolini, Andrea Balboni, Marinella Roberti, Janet Robertson, Giuseppina Di Stefano, Fulvia Farabegoli, Sebastiano Peri, Jose Antonio Ortega, Saverio Minucci, D. Gioia, Federico Falchi, Domenico Milano, Francesca De Franco, Fabrizio Schipani, Roberto Pellicciari, Andrea Cavalli, Marcella Manerba, Stefania Girotto
Publikováno v:
Journal of Medicinal Chemistry
Synthetic lethality is an innovative framework for discovering novel anticancer drug candidates. One example is the use of PARP inhibitors (PARPi) in oncology patients with BRCA mutations. Here, we exploit a new paradigm based on the possibility of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a9ce8f1a24b0337c5b7b86be9e4f0a
https://doi.org/10.1021/acs.jmedchem.9b01526
https://doi.org/10.1021/acs.jmedchem.9b01526
Autor:
Irene Brusa, Elvira Sondo, Federico Falchi, Nicoletta Pedemonte, Marinella Roberti, Andrea Cavalli
In cystic fibrosis (CF), the deletion of phenylalanine 508 (F508del) in the CF transmembrane conductance regulator (CFTR) leads to misfolding and premature degradation of the mutant protein. These defects can be targeted with pharmacological agents n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f683b9eae734b0a2276958a1a951cd86
http://hdl.handle.net/11585/884305
http://hdl.handle.net/11585/884305
Autor:
Alessandra Salerno, Francesca Seghetti, Jessica Caciolla, Elisa Uliassi, Eleonora Testi, Melissa Guardigni, Marinella Roberti, Andrea Milelli, Maria Laura Bolognesi
Proteolysis targeting chimera (PROTAC)-mediated protein degradation has prompted a radical rethink and is at a crucial stage in driving a drug discovery transition. To fully harness the potential of this technology, a growing paradigm toward enrichin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2241d5454709a39655dbc52473b803d
https://hdl.handle.net/11585/894851
https://hdl.handle.net/11585/894851
Autor:
Marcella Manerba, Stefania Girotto, Fabrizio Schipani, Nicola Tirelli, Arianna Gennari, Andrea Armirotti, Roberto Marotta, Walter Rocchia, Giuseppina Di Stefano, Andrea Cavalli, Francesco Rinaldi, Marinella Roberti
RAD51, a key player in the homologous recombination (HR) mechanism, is a critical protein to preserve genomic stability. BRCA2, upon DNA damage, promotes RAD51 fibrils disassembly and its nuclear recruitment.Here, we use BRC4, a peptide derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d08f380a2c2fc76b743cf92e0d1558
https://doi.org/10.1101/2021.02.03.429564
https://doi.org/10.1101/2021.02.03.429564
Autor:
Marcella Manerba, Giuseppina Di Stefano, Andrea Balboni, Andrea Cavalli, Marzia Govoni, Marinella Roberti, Valentina Rossi
Background Cancer cells show highly increased glucose utilization which, among other cancer-essential functions, was found to facilitate DNA repair. Lactate dehydrogenase (LDH) activity is pivotal for supporting the high glycolytic flux of cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12c00554c243aa1c3bae35231a1f3fb
http://hdl.handle.net/11585/781224
http://hdl.handle.net/11585/781224