Výsledky vyhledávání - "MARICA ARVIGO"

β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids

Autor: Diego Ferone, Richard A Feelders, Fadime Dogan, Peter M. van Koetsveld, Federico Gatto, Eleonora Bruzzone, Leo J. Hofland, Steven W. J. Lamberts, Marica Arvigo, Rob van der Pas

Publikováno v: Journal of Endocrinology, 245(1), 101-113. Bioscientifica Ltd

Pituitary-directed medical treatment for Cushing’s disease (CD) is currently represented by membrane receptor targeting drugs (somatostatin analogs and dopamine agonists). Somatostatin and dopamine receptors are regulated by β-arrestins, which hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d412f606640a89f9f81fb08f67a43398
https://doi.org/10.1530/joe-19-0311

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Octreotide and Pasireotide Combination Treatment in Somatotroph Tumor Cells: Predominant Role of SST2 in Mediating Ligand Effects

Autor: Tullio Florio, Gianluigi Zona, Adriana Bajetto, Marica Arvigo, Diego Criminelli Rossi, Gabriele Gaggero, Diego Ferone, Alessandro Prior, Federica Nista, Claudia Campana, Federico Gatto, Federica Barbieri, Jessica Amarù, Agnese Solari

Publikováno v: Cancers
Volume 13
Issue 8
Cancers, Vol 13, Iss 1816, p 1816 (2021)

First-generation somatostatin receptor ligands (fg-SRLs), such as octreotide (OCT), represent the first-line medical therapy in acromegaly. Fg-SRLs show a preferential binding affinity for somatostatin receptor subtype-2 (SST2), while the second-gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1dc89c1bc791fef4e6bd17bba62505
http://europepmc.org/articles/PMC8069349

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Discordant GH and IGF-1 Results in Treated Acromegaly: Impact of GH Cutoffs and Mean Values Assessment

Autor: Claudia Campana, Diego Ferone, Federico Gatto, Marica Arvigo, Francesco Cocchiara, Jessica Amarù, Federica Nista, Giuliana Corica, Gianluigi Zona, Diego Criminelli Rossi

Context Discordant growth hormone (GH) and insulin-like growth factor-1 (IGF-1) values are frequent in acromegaly. Objective To evaluate the impact of different GH cutoffs on discordance rate. To investigate whether the mean of consecutive GH measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d7f80f35ed23a7057ee2d77ddee6a5
http://hdl.handle.net/11567/1044725

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Somatostatin receptor expression and patients' response to targeted medical treatment in pituitary tumors: evidences and controversies

Autor: Diego Ferone, Federico Gatto, Marica Arvigo

Somatostatin receptors (SSTs) are widely co-expressed in pituitary tumors. SST2 and SST5 are the most represented SST subtypes. First-generation somatostatin receptor ligands (SRLs) mainly target SST2, while pasireotide, a multi-receptor ligand, show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728c58be7888f09e1f4591f88b7c2c94
http://hdl.handle.net/11567/1023426

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Cell specific interaction of pasireotide: review of preclinical studies in somatotroph and corticotroph pituitary cells

Autor: Federico Gatto, Massimo Giusti, Mara Boschetti, Eleonora Bruzzone, Francesco Cocchiara, Marica Arvigo, Diego Ferone, Giulia Graziani, Jessica Amarù, Claudia Campana

Pasireotide is a second-generation somatostatin (SRIF) receptor ligand (SRL), approved for medical treatment of acromegaly and Cushing’s disease (CD). The molecule is a stable cyclohexapeptide synthetized based on SRIF structure. Differently from f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdbe93b597276e12cd99e43919d3ada
https://hdl.handle.net/11567/937621

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Epidemiology of acromegaly in Italy: analysis from a large longitudinal primary care database

Autor: Francesco Cocchiara, Carmen Ferrajolo, Carlotta Dell’Aquila, Marica Arvigo, Claudio Cricelli, Gianluca Trifirò, Diego Ferone, Federico Gatto, Francesco Lapi, Claudia Campana, Massimo Giusti

Purpose: Epidemiological data are pivotal for the estimation of disease burden in populations. Aim: Of the study was to estimate the incidence and prevalence of acromegaly in Italy along with the impact of comorbidities and hospitalization rates as c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834e59572c135beb397834661f6a104e
http://hdl.handle.net/11562/1039565

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Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2: a rare entity

Autor: Laura Blackwood, Gianna Baroni, Riccardo Finotello, Rachel Burrow, Lorenzo Ressel, Veronica Marchetti, D Mignacca, Giorgio Romanelli, Marica Arvigo

Publikováno v: Veterinary and Comparative Oncology. 14:170-180

Insulin-like growth factor type II (IGF-II) is the main cause of non-islet cell tumour hypoglycaemia (NICTH) and insulin is thought to be the only factor causing hypoglycaemia in insulinomas. However, two case reports of pancreatic neuroendocrine tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b699d8dd324318966cb69ef31d53ba9
https://doi.org/10.1111/vco.12085

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Somatostatin receptor pathophysiology in the neuroendocrine system

Autor: Diego Ferone, Marica Arvigo, Francesco Minuto, Mara Boschetti, Federico Gatto, Manuela Albertelli

Publikováno v: Expert Review of Endocrinology & Metabolism. 8:149-157

The actions of somatostatin (SRIF) are mediated by specific G protein-coupled receptors, named SRIF receptor (SSTR) subtypes 1, 2, 3 and 5. SRIF binding to SSTR activates a series of second messenger systems, resulting in the inhibition of calcium ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bd656a1e8533a8ebd07d2140a21727
https://doi.org/10.1586/eem.13.7

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Bone turnover and mineral density in adult thalassemic patients: relationships with growth hormone secretory status and circulating somatomedins

Autor: Diego Ferone, Marica Arvigo, Leila Danesi, Raffaella Radin, Laura Zanaboni, Mara Boschetti, Giovanna Sciortino, Emanuela D'Angelo, Elena Cassinerio, Marina Baldini, Maria Domenica Cappellini, Giovanni Vitale, Agnese Cattaneo, Alberto Giacinto Ambrogio, Paolo Marzullo, Nadia Mirra, Francesco Cavagnini, Massimo Scacchi, Luca Persani

Previous evidence supports a role for growth hormone (GH)-insulin-like growth factor (IGF)-I deficiency in the pathophysiology of osteopenia/osteoporosis in adult thalassemia. Moreover, serum IGF-II has never been studied in this clinical condition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efae7fbdeda2783db4429e09914356
http://hdl.handle.net/11567/851013

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The clinical–molecular interface of somatostatin, dopamine and their receptors in pituitary pathophysiology

Autor: Federico Gatto, Marica Arvigo, Mara Boschetti, Eugenia Resmini, Claudia Teti, Francesco Minuto, Diego Ferone, Daniela Esposito

Publikováno v: Journal of Molecular Endocrinology. 42:361-370

The role of somatostatin and dopamine receptors as molecular targets for the treatment of patients with pituitary adenomas is well established. Indeed, dopamine and somatostatin receptor agonists are considered milestones for the medical therapy of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c978ff0a89e5152d689df4216dd53a1
https://doi.org/10.1677/jme-08-0162

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