Zobrazeno 1 - 10 of 62 pro vyhledávání: '"MARIA PAZ ZAFRA"'
1
Akademický článek
Oncogenic context shapes the fitness landscape of tumor suppression
Autor: Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain po
Externí odkaz: https://doaj.org/article/d8b8fe0a0e6941c7a811944dff8fc5cc
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2
Akademický článek
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
Autor: Teng Han, Emma M. Schatoff, Charles Murphy, Maria Paz Zafra, John E. Wilkinson, Olivier Elemento, Lukas E. Dow
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours ext
Externí odkaz: https://doaj.org/article/1723273cb2e14f359f103ef93504189d
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6
Data from Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition
Autor: Lukas E. Dow, Bianca J. Diaz, Alyna Katti, Benjamin I. Leach, Michael Shusterman, Miguel Foronda, Maria Paz Zafra, Sukanya Goswami, Emma M. Schatoff
The majority of colorectal cancers show hyperactivated WNT signaling due to inactivating mutations in the adenomatous polyposis coli (APC) tumor suppressor. Genetically restoring APC suppresses WNT and induces rapid and sustained tumor regression, im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5abd6f8d58ad9ae339c892d786ec2b32
https://doi.org/10.1158/2159-8290.c.6547946.v1
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8
Data from An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants
Autor: Lukas E. Dow, Elena Piskounova, John E. Wilkinson, Maria Teresa Calvo Fernandez, Alyna Katti, Teng Han, Emma M. Schatoff, Sukanya Goswami, Direna Alonso-Curbelo, Jangkyung Kim, Marie J. Parsons, Maria Paz Zafra
KRAS is the most frequently mutated oncogene in cancer, yet there is little understanding of how specific KRAS amino acid changes affect tumor initiation, progression, or therapy response. Using high-fidelity CRISPR-based engineering, we created an a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2a350105ade263bfaaceb975594f9b9
https://doi.org/10.1158/2159-8290.c.6547792.v1
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