DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort

Autor: Sarah Damanti, Lorena Citterio, Laura Zagato, Elena Brioni, Cristiano Magnaghi, Marco Simonini, Rebecca De Lorenzo, Mariapia Ruggiero, Simona Santoro, Eleonora Senini, Marco Messina, Giordano Vitali, Paolo Manunta, Angelo Andrea Manfredi, Chiara Lanzani, Patrizia Rovere Querini

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

BackgroundObesity and frailty are prevalent geriatric conditions that share some pathophysiological mechanisms and are associated with adverse clinical outcomes. The relationship between frailty, obesity, and polymorphism remains inadequately explore

Externí odkaz: https://doaj.org/article/0021cfe230394661bb3b105476656a17

ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa

Autor: Jean-Frédéric Dubern, Manuel Romero, Anne Mai-Prochnow, Marco Messina, Eleftheria Trampari, Hardeep Naghra-van Gijzel, Kok-Gan Chan, Alessandro M. Carabelli, Nicolas Barraud, James Lazenby, Ye Chen, Shaun Robertson, Jacob G. Malone, Paul Williams, Stephan Heeb, Miguel Cámara

Publikováno v: npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-12 (2022)

Abstract Pseudomonas aeruginosa uses multiple protein regulators that work in tandem to control the production of a wide range of virulence factors and facilitate rapid adaptation to diverse environmental conditions. In this opportunistic pathogen, T

Externí odkaz: https://doaj.org/article/4aa08aca28374cf58e283dd4b2ed23e6

Randomized phase II trial of avelumab alone or in combination with cetuximab for patients with previously treated, locally advanced, or metastatic squamous cell anal carcinoma: the CARACAS study

Autor: Matteo Fassan, Fotios Loupakis, Sara Lonardi, Federica Morano, Mariaelena Casagrande, Filippo Pietrantonio, Gianluca Masi, Marco Messina, Andrea Sartore-Bianchi, Paola Del Bianco, Francesca Bergamo, Angela Buonadonna, Vittorina Zagonel, Massimiliano Spada, Monica Ronzoni, Salvatore Corallo, Michele Prisciandaro, Giovanni Luca Frassineti, Alessandra Anna Prete, Vincenzo Formica, Domenico Cristiano Corsi, Corrado Orciuolo, Maria Giulia Zampino, Mario Scartozzi, Stefania Mosconi, Margherita Ratti, Emiliano Tamburini, Valentina Vettore

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)

Externí odkaz: https://doaj.org/article/d2055ec40a69404eb78acf9876dff918

Inflammatory indices and clinical factors in metastatic renal cell carcinoma patients treated with nivolumab: the development of a novel prognostic score (Meet-URO 15 study)

Autor: Sara Elena Rebuzzi, Alessio Signori, Giuseppe Luigi Banna, Marco Maruzzo, Ugo De Giorgi, Paolo Pedrazzoli, Andrea Sbrana, Paolo Andrea Zucali, Cristina Masini, Emanuele Naglieri, Giuseppe Procopio, Sara Merler, Laura Tomasello, Lucia Fratino, Cinzia Baldessari, Riccardo Ricotta, Stefano Panni, Veronica Mollica, Mariella Sorarù, Matteo Santoni, Alessio Cortellini, Veronica Prati, Hector Josè Soto Parra, Marco Stellato, Francesco Atzori, Sandro Pignata, Carlo Messina, Marco Messina, Franco Morelli, Giuseppe Prati, Franco Nolè, Francesca Vignani, Alessia Cavo, Giandomenico Roviello, Francesco Pierantoni, Chiara Casadei, Melissa Bersanelli, Silvia Chiellino, Federico Paolieri, Matteo Perrino, Matteo Brunelli, Roberto Iacovelli, Camillo Porta, Sebastiano Buti, Giuseppe Fornarini

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 13 (2021)

Background: Despite the survival advantage, not all metastatic renal cell carcinoma (mRCC) patients achieve a long-term benefit from immunotherapy. Moreover, the identification of prognostic biomarkers is still an unmet clinical need. Methods: This m

Externí odkaz: https://doaj.org/article/b7fbd6a0e95e4fbc8e3f9aaff8b8f0d2

Impact of COVID-19 outbreak on cancer immunotherapy in Italy: a survey of young oncologists

Autor: Valentina Massa, Andrea Sbrana, Fortunato Ciardiello, Carminia Maria Della Corte, Floriana Morgillo, Dario Trapani, Sandro Pignata, Antonio Avallone, Vincenzo Montesarchio, Marco Messina, Paolo Antonio Ascierto, Ester Simeone, Antonio Maria Grimaldi, Marcello Curvietto, Lucia Festino, Michela Lia, Giacomo Cartenì, Luisa Piccin, Bruno Daniele, Sabino De Placido, Cesare Gridelli, Stefano Pepe, Vito Vanella, Giuseppe Palmieri, Maria Grazia Vitale, Alessandro Morabito, Margaret Ottaviano, Pasquale Rescigno, Marianna Tortora, Giovannella Palmieri, Michele Aieta, Pasquale Assalone, Laura Attademo, Francesco Bloise, Davide Bosso, Valentina Borzillo, Giuseppe Buono, Giuseppe Calderoni, Francesca Caputo, Diletta Cavallero, Alessia Cavo, Raffaele Conca, Vincenza Conteduca, Stefano De Falco, Marco De Felice, Michelino De Laurentiis, Pietro De Placido, Irene De Santo, Alfonso De Stefano, Rossella Di Franco, Vincenzo Di Lauro, Antonietta Fabbrocini, Piera Federico, Pasqualina Giordano, Mario Giuliano, Antonella Lucia Marretta, Alessia Mennitto, Sara Merler, Valeria Merz, Carlo Messina, Monica Milano, Alessandro Marco Minisini, Brigitta Mucci, Lucia Nappi, Fabiana Napolitano, Immacolata Paciolla, Martina Pagliuca, Sara Parola, Angelica Petrillo, Francovito Piantedosi, Fernanda Picozzi, Erica Pietroluongo, Veronica Prati, Vittorio Riccio, Mario Rosanova, Alice Rossi, Anna Russo, Massimiliano Salati, Giuseppe Santabarbara, Antonia Silvestri, Massimiliano Spada, Paolo Tarantino, Paola Taveggia, Federica Tomei, Tortora Vincenzo, Claudia Trojanello, Sabrina Vari, Jole Ventriglia, Fabiana Vitiello, Caterina Vivaldi, Claudia von Arx, Francesca Zacchi, Ilaria Zampiva, Andrea Zivi

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background The coronavirus disease 2019 (COVID-19) pandemic has overwhelmed the health systems worldwide. Data regarding the impact of COVID-19 on cancer patients (CPs) undergoing or candidate for immune checkpoint inhibitors (ICIs) are lacking. We d

Externí odkaz: https://doaj.org/article/64743faa9b7a4b10b9520d6339d9ebce