IL-1β promotes MPN disease initiation by favoring early clonal expansion ofJAK2-mutant hematopoietic stem cells

Autor: Shivam Rai, Yang Zhang, Elodie Grockowiak, Quentin Kimmerlin, Nils Hansen, Cedric B. Stoll, Marc Usart, Hui Hao-Shen, Michael S. Bader, Jakob R. Passweg, Stefan Dirnhofer, Christopher J. Farady, Timm Schroeder, Simón Méndez-Ferrer, Radek C. Skoda

JAK2-V617F is the most frequent somatic mutation causing myeloproliferative neoplasm (MPN). However,JAK2-V617F can also be found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP) with a frequency much higher than the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14733e1fc258e0cbd8402d7f500276c2
https://doi.org/10.1101/2023.05.21.541610

Combination of 5-Azacytidine and Pegifna Is Able to Overcome Resistance in JAK2-V617F Positive MPN with Loss of Dnmt3a

Autor: Melissa Lock, Damien Luque Paz, Nils Hansen, Tiago Almeida Fonseca, MARC Usart, Shivam Rai, Hui Hao-Shen, Gabriele Mild, Stephan Dirnhofer, Radek C. Skoda, Jan Stetka

Publikováno v: Blood. 140:3876-3877

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::639d69471d1918b6fabf2ff3b6ddb3fc
https://doi.org/10.1182/blood-2022-167002

Disrupting the Socs2-Mediated Negative Feedback to JAK-STAT Signaling Boosts Molecular Responses Induced By Interferon-α in a Mouse Model of Myeloproliferative Neoplasms

Autor: Marc Usart, Cédric B. Stoll, Riikka Karjalainen, Hui Hao-Shen, Radek C. Skoda

Publikováno v: Blood. 140:9580-9581

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d6aea48fbcfe6de16ecd2529be79a9
https://doi.org/10.1182/blood-2022-169232

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

Autor: Caleb Weinreb, Allon M. Klein, Shou-Wen Wang, Rosa Portero Migueles, Alejo E. Rodriguez-Fraticelli, Fernando D. Camargo, Sally Lowell, Maja Jankovic, Marc Usart

Publikováno v: Nature
Rodriguez-Fraticelli, A E, Weinreb, C S, Wang, S-W, Portero Migueles, M R, Jankovic, M, Usart, M, Klein, A M, Lowell, S & Camargo, F 2020, ' Single-cell lineage tracing unveils a role for Tcf15 in haematopoiesis ', Nature, vol. 583, pp. 585-589 . https://doi.org/10.1038/s41586-020-2503-6

Bone marrow transplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs)1,2. HSCs present a complex variety of regenerative behaviours at the clonal level, but the mechanisms underlying this diversity are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9cb3147eb6660ad50fc3d8a0b120fb
https://doi.org/10.1038/s41586-020-2503-6

Inhibiting Glutamine Metabolism with CB-839 Reduces Erythrocytosis in MPN Mice

Autor: Tata Nageswara Rao, Shivam Rai, Hui Hao-Shen, Alexandre Guy, Marc Usart, Jan Stetka, Radek C. Skoda, Nils Hansen

Publikováno v: Blood. 138:3585-3585

Metabolic reprogramming is one of the hallmarks of cancer, as these rapidly dividing cells need to adapt their metabolism to cope with an increased energy demand. We have previously showed that in mouse models of myeloproliferative neoplasms (MPN), J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46b944c705902104e1660965b799a6a1
https://doi.org/10.1182/blood-2021-150321