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Akademický článek

MAPK-activated protein kinase 2 is associated with poor prognosis of glioma patients and immune inhibition in glioma

Autor: Jinmin Sun, Sicheng Wu, Wenyu Zhao, Senrui Xue, Lei Zhang, Jing Ren

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionAn effective therapeutic method to noticeably improve the prognosis of glioma patients has not been developed thus far. MAPK-activated protein kinase 2 (MAPKAPK2) is a serine/threonine kinase, which is involved in tumorigenesis, tumor gro

Externí odkaz: https://doaj.org/article/1664a05141094137baa70699ba4a9083

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Akademický článek

MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC pathogenesis

Autor: Sourabh Soni, Prince Anand, Mohit Kumar Swarnkar, Vikram Patial, Narendra V. Tirpude, Yogendra S. Padwad

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1292-1311 (2023)

Transcriptome analysis of head and neck squamous cell carcinoma (HNSCC) has been pivotal to comprehending the convoluted biology of HNSCC tumors. MAPKAPK2 or MK2 is a critical modulator of the mRNA turnover of crucial genes involved in HNSCC progress

Externí odkaz: https://doaj.org/article/f2b91e1a02b5405b8dab07343222e008

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Akademický článek

MK2 drives progression of pancreas and colon cancers by suppressing CD8+ T cell cytotoxic function and is a potential immunotherapy target

Autor: Damian Jacenik, Eric J. Lebish, Ellen J. Beswick

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundImmune cell composition is a critical and dynamic component of the tumor microenvironment, which has an impact on immunosuppression and progression of cancer. T cells, especially CD8+ T cells, are one of the major immune cell types responsi

Externí odkaz: https://doaj.org/article/78f38482574642fbaf402f2dab6af8fb

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Akademický článek

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Akademický článek

Revealing oxidative stress-related genes in osteoporosis and advanced structural biological study for novel natural material discovery regarding MAPKAPK2

Autor: Yingjing Zhao, Weihang Li, Kuo Zhang, Meng Xu, Yujia Zou, Xiaotong Qiu, Tianxing Lu, Bo Gao

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

ObjectivesThis study aimed to find novel oxidative stress (OS)-related biomarkers of osteoporosis (OP), together with targeting the macromolecule Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) protein to further discover poten

Externí odkaz: https://doaj.org/article/b79f6d142bd64e1bb5307b7fc94d3710

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Akademický článek

MK2 Inhibitors as a Potential Crohn’s Disease Treatment Approach for Regulating MMP Expression, Cleavage of Checkpoint Molecules and T Cell Activity

Autor: Eric J. Lebish, Natalie J. Morgan, John F. Valentine, Ellen J. Beswick

Publikováno v: Pharmaceuticals, Vol 15, Iss 12, p 1508 (2022)

Crohn’s Disease (CD) and Ulcerative Colitis (UC) are the two major forms of inflammatory bowel disease (IBD), which are incurable chronic immune-mediated diseases of the gastrointestinal tract. Both diseases present with chronic inflammation that l

Externí odkaz: https://doaj.org/article/e6cf1ea6eb074feb81efb6b3cf400c53

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Akademický článek

T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain

Autor: Jayden A. O'Brien, Helen M. McGuire, Diana Shinko, Barbara Fazekas de St Groth, Marc A. Russo, Dominic Bailey, Danielle M. Santarelli, Katie Wynne, Paul J. Austin

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 15, Iss , Pp 100283- (2021)

Diabetic neuropathic pain is a common and devastating complication of type 1 diabetes, but the mechanism by which it develops and persists is yet to be fully elucidated. This study utilised high-dimensional suspension mass cytometry in a pilot cohort

Externí odkaz: https://doaj.org/article/435fcfc6ded54c1c80ad5ce8e786e538

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Akademický článek

MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability

Autor: Sourabh Soni, Munish Kumar Saroch, Bal Chander, Narendra Vijay Tirpude, Yogendra S. Padwad

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)

Abstract Background Head and neck squamous-cell carcinoma (HNSCC) ranks sixth among cancers worldwide. Though several molecular mechanisms of tumor initiation and progression of HNSCC are known, others remain unclear. Significance of p38/MAPKAPK2 (Mi

Externí odkaz: https://doaj.org/article/0509179cbc954eff879a0ca9fe280d46

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