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pro vyhledávání: '"MAPK signaling cascades"'
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10185 (2022)
Mitogen-activated protein kinase (MAPK) cascades are highly conserved signal transduction modules, which transmit environmental signals in plant cells through stepwise phosphorylation and play indispensable roles in a wide range of physiological and
Externí odkaz:
https://doaj.org/article/d8386c9b4efd4080aaabf699ec898e51
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262739 (2022)
PLoS ONE
PLoS ONE
Human T-cell Leukemia Virus type-1 (HTLV-1) is an oncovirus that may cause two main life-threatening diseases including a cancer type named Adult T-cell Leukemia/Lymphoma (ATLL) and a neurological and immune disturbance known as HTLV-1 Associated Mye
Autor:
Takashi Naka
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0263111 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0263111 (2022)
The signal transduction system, which is known as a regulatory mechanism for biochemical reaction systems in the cell, has been the subject of intensive research in recent years, and its design methods have become necessary from the viewpoint of synt
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010027 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background The metacestode larval stage of the fox-tapeworm Echinococcus multilocularis causes alveolar echinococcosis by tumour-like growth within the liver of the intermediate host. Metacestode growth and development is stimulated by host-derived c
Autor:
Eric Blanc, Joern Toedling, Tommaso Mari, Angelika Eggert, Mathurin Dorel, Anja Sieber, Michal Nadler-Holly, Matthias Selbach, F Hertwig, Matthias Ziehm, Clemens Messerschmidt, Nils Blüthgen, Johannes H. Schulte, Bertram Klinger, Dieter Beule
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11 (2021)
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 11, p e1009515 (2021)
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 11, p e1009515 (2021)
Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and found that the sensitivity to MEK inhi
Autor:
Upinder S. Bhalla
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009621 (2021)
PLoS Computational Biology
PLoS Computational Biology
Signaling networks mediate many aspects of cellular function. The conventional, mechanistically motivated approach to modeling such networks is through mass-action chemistry, which maps directly to biological entities and facilitates experimental tes
Autor:
Xiuyun Tian, Guang-Jun He, Ence Yang, Hao Ding, Linqi Wang, Huimin Liu, Cheng Jin, Pengjie Hu, Changyu Tao, Jingnan Liang, Xinping Xu, Xiangzheng Bai, Lan Shen
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10, p e1009817 (2021)
PLoS Genetics, Vol 17, Iss 10, p e1009817 (2021)
The yeast-to-hypha transition is tightly associated with pathogenicity in many human pathogenic fungi, such as the model fungal pathogen Cryptococcus neoformans, which is responsible for approximately 180,000 deaths annually. In this pathogen, the ye
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009971 (2021)
PLoS Pathogens
PLoS Pathogens
Viruses have evolved mechanisms to subvert critical cellular signaling pathways that regulate a wide range of cellular functions, including cell differentiation, proliferation and chemotaxis, and innate immune responses. Here, we describe a novel ORF
Akademický článek
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