Zobrazeno 1 - 10
of 63
pro vyhledávání: '"MAPK, mitogen activated protein kinases"'
Autor:
Christophe Glorieux, Peng Huang
Publikováno v:
Cancer Communications, Vol 39, Iss 1, Pp 1-11 (2019)
Abstract Background The interaction between CD137 and its ligand (CD137L) plays a major role in the regulation of immune functions and affects cancer immunotherapy. CD137 is a cell surface protein mainly located on activated T cells, and its regulati
Externí odkaz:
https://doaj.org/article/0557979dbd21466ab387605fa3f7d6a5
Publikováno v:
Genes and Diseases, Vol 8, Iss 2, Pp 117-123 (2021)
Genes & Diseases
Genes & Diseases
Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out of these were obese during 2016. There is a significant relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3b6d350d2765a112ecc8a00cead5d6
https://doi.org/10.1016/j.gendis.2019.09.006
https://doi.org/10.1016/j.gendis.2019.09.006
Autor:
Bulbuli Khanikor, Kamal Adhikari
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 1883-1891 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Aedes aegypti mosquitoes were exposed to temephos for 28 generations. • This exposure led to a 7.83-fold decrease in temephos toxicity. • With increase in generational time, Ae. aegypti exhibited increased d
Highlights • Aedes aegypti mosquitoes were exposed to temephos for 28 generations. • This exposure led to a 7.83-fold decrease in temephos toxicity. • With increase in generational time, Ae. aegypti exhibited increased d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b571ea088759d5527f53f95bb8e770b
http://www.sciencedirect.com/science/article/pii/S2214750021001979
http://www.sciencedirect.com/science/article/pii/S2214750021001979
Autor:
Anuar Salazar-Gómez, Saudy Saret Pablo-Pérez, M. Elena Vargas-Dı́az, Julio C. Ontiveros-Rodríguez, Leticia Garduño-Siciliano
Publikováno v:
South African Journal of Botany
Highlights • Definition and pathogenesis of metabolic syndrome is briefly described. • Sesquiterpene lactones isolated from medicinal plants used in traditional medicine. • In vivo and in vitro biological activities of sesquiterpene lactones ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512583e8aceec7a8d3995bc13c6d8a6c
https://doi.org/10.1016/j.sajb.2020.08.020
https://doi.org/10.1016/j.sajb.2020.08.020
Autor:
Alexandre Gries, Michael A. Grotzer, Anuja Neve, Marc Thomas Schönholzer, Min Ma, Karthiga Santhana Kumar, Martin Baumgartner, Jessica Migliavacca, Elena Alvarez
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)
Highlights • Growth factor signaling causes sustained nuclear ERK1/2 activation. • The SCR and BCR/ABL inhibitor dasatinib blocks ERK1/2 and represses cell invasion. • EGF-stimulated cells may escape dasatinib inhibition of invasion through mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a076863a1a0810fcffc300433bde15b
http://europepmc.org/articles/PMC7452206
http://europepmc.org/articles/PMC7452206
Autor:
Shengbing Yang, Hanjun Li, Jingtian Mei, Han Qiao, Feng Zhou, Minqi Wang, Linyang Chu, Tingting Tang, Xiuguo Han
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)
The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) progression. RAW264.7 macrophages were polarized to M1/M2 subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657da9eb0531d9727733222372f40b72
http://europepmc.org/articles/PMC6804452
http://europepmc.org/articles/PMC6804452
Autor:
Emma Rose McGlone, Alejandra Tomas, Sunil Kumar, Zijian Fang, Ben Jones, Paul M. W. French, Stephen R. Bloom, Phil Pickford, Christopher Dunsby, Asuka Inoue, Tricia Tan, Ivan R. Corrêa, Frederik Görlitz, Ralf Jockers, Guy A. Rutter, Atsuro Oishi
Publikováno v:
The Journal of Biological Chemistry
Receptors for the peptide hormones glucagon-like peptide-1 (GLP-1R), glucose-dependent insulinotropic polypeptide (GIPR), and glucagon (GCGR) are important regulators of insulin secretion and energy metabolism. GLP-1R agonists have been successfully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14471befc4ee6d914cdba212a163e9f9
http://hdl.handle.net/10044/1/85112
http://hdl.handle.net/10044/1/85112
Publikováno v:
Pharmacological Research
Graphical abstract Molecular targets modulated by artemisinins in respiratory diseases.
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatm
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184b9b3d7b7767e97cb84ac3227c7da4
Autor:
Kinga Gawlińska, Edmund Przegaliński, Michal Korostynski, Marcin Piechota, Małgorzata Filip, Dawid Gawliński, Małgorzata Frankowska, Malgorzata Borczyk
Publikováno v:
Developmental Cognitive Neuroscience
Developmental Cognitive Neuroscience, Vol 47, Iss, Pp 100879-(2021)
Developmental Cognitive Neuroscience, Vol 47, Iss, Pp 100879-(2021)
Graphical abstract
Highlights • Modified maternal diet influences offspring behavior and the brain transcriptome. • Maternal HFD provokes depressive-like behavior in male and female offspring. • In utero exposure to HFD leads to transcript
Highlights • Modified maternal diet influences offspring behavior and the brain transcriptome. • Maternal HFD provokes depressive-like behavior in male and female offspring. • In utero exposure to HFD leads to transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bae2d238f2480a6178de8a3ff40a278
https://pubmed.ncbi.nlm.nih.gov/33232913
https://pubmed.ncbi.nlm.nih.gov/33232913
Autor:
Puja Ohri, Ajaz Ahmad, Renu Bhardwaj, Sukhmeen Kaur Kohli, Abhay Bhardwaj, Anket Sharma, Kanika Khanna, Parvaiz Ahmad, Ravdeep Kaur, Vinay Bhardwaj
Publikováno v:
Phytomedicine
Highlights • Coronavirus pandemic has created a global alarming situation. • SARS-CoV shares sequence homology with bats, therefore, considered as origin. • Scientists are burning midnight's oil to discover drug or vaccine against this deleteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83c8a8eaabda09eb05a778c447fbacd
https://pubmed.ncbi.nlm.nih.gov/33485605
https://pubmed.ncbi.nlm.nih.gov/33485605