Zobrazeno 1 - 10
of 398
pro vyhledávání: '"MAO‐B inhibitor"'
Autor:
Fabrizio Stocchi, Paolo Barone, Roberto Ceravolo, Maria Francesca De Pandis, Leonardo Lopiano, Nicola Modugno, Alessandro Padovani, Manuela Pilleri, Alessandro Tessitore, Mario Zappia
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
AbstractBackground Oral levodopa remains the mainstay of treatment for Parkinson’s disease (PD). However, as PD progresses, response to treatment may fluctuate. Managing fluctuations can be demanding for clinicians and patients. There is a paucity
Externí odkaz:
https://doaj.org/article/702afcd4a74a4f599a04d871df252cc2
Autor:
Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 100-117 (2023)
Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine
Externí odkaz:
https://doaj.org/article/474848c2851c400e9f7f9cec71ca3915
Autor:
Michael Strupp, Grant C. Churchill, Ivonne Naumann, Ulrich Mansmann, Amani Al Tawil, Anastasia Golentsova, Nicolina Goldschagg
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundBetahistine was registered in Europe in the 1970s and approved in more than 80 countries as a first-line treatment for Menière's disease. It has been administered to more than 150 million patients. However, according to a Cochrane systemat
Externí odkaz:
https://doaj.org/article/461639fe2ac04f599647a45524256226
Akademický článek
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Autor:
Ahmed Elkamhawy, Sora Paik, Hyeon Jeong Kim, Jong-Hyun Park, Ashwini M. Londhe, Kyeong Lee, Ae Nim Pae, Ki Duk Park, Eun Joo Roh
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1568-1580 (2020)
Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hits VI and VII, co
Externí odkaz:
https://doaj.org/article/dbd0beecfde24674a5c60b6407638e97
Autor:
Nobutaka Hattori, Yuki Kogo, Michinori Koebis, Takayuki Ishida, Ippei Suzuki, Yoshio Tsuboi, Masahiro Nomoto
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
Background and PurposeNeuropsychiatric symptoms in Parkinson's disease (PD) have been shown to significantly affect quality of life (QOL). We investigated the impact of safinamide on depression and apathy when administered as an adjunct to levodopa i
Externí odkaz:
https://doaj.org/article/aaea7af9935b4baabb0f41d5503798a4
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Sotirios Grigoriou, Pablo Martínez‐Martín, K. Ray Chaudhuri, Katarina Rukavina, Valentina Leta, Denise Hausbrand, Björn Falkenburger, Per Odin, Heinz Reichmann
Publikováno v:
Brain and Behavior, Vol 11, Iss 10, Pp n/a-n/a (2021)
Abstract Background Non‐motor symptoms (NMS) are integral to Parkinson's Disease (PD) and management remains a challenge. Safinamide is a novel molecule in relation to addressing NMS due to its multifocal mechanism of action with both dopaminergic
Externí odkaz:
https://doaj.org/article/e63969ecf78945b0ae7016789b8887e5
Autor:
Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner-Link, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2187 (2022)
The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H3 receptor (H3R) and MAO B can increase DA levels in the brain. A series o
Externí odkaz:
https://doaj.org/article/9d182e4dcb5d4290bc05ad6a476c576a
Autor:
Zhen-Ru Xia-Hou, Xiao-Fei Feng, Yu-Fei Mei, Yin-Yan Zhang, Tong Yang, Jie Pan, Jing-Hua Yang, Yun-Song Wang
Publikováno v:
Molecules, Vol 27, Iss 15, p 4950 (2022)
Rutaceae plants are known for being a rich source of coumarins. Preliminary molecular docking showed that there was no significant difference for coumarins in Clausena and Murraya, both of which had high scoring values and showed good potential inhib
Externí odkaz:
https://doaj.org/article/a1883f029de94db8b4d0a6e71f239a29