Zobrazeno 1 - 10
of 475
pro vyhledávání: '"MANUEL SALTO-TELLEZ"'
Autor:
Victoria Bingham, Louise Harewood, Stephen McQuaid, Stephanie G. Craig, Julia F. Revolta, Chang S. Kim, Shambhavi Srivastava, Javier Quezada-Marín, Matthew P. Humphries, Manuel Salto-Tellez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies. Tissue microarrays (TMA) are an established method of high throughput biomarker interrogation in tissues but may not capture histological features of
Externí odkaz:
https://doaj.org/article/d25a41f56be2446d9bbeea882fd613c5
Autor:
Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Francesca Buffa, Geoffrey Higgins, Christopher Holmes, Timothy Maughan, Gillies McKenna, James Robineau, Philip Quirke, Matthew Seymour, Richard Kennedy, Mark Lawler, Manuel Salto-Tellez, Peter Campbell, Claire Hardy, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Richard Wilson, Richard Adams, Richard Sullivan, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105228- (2024)
Summary: Background: It is uncertain which biological features underpin the response of rectal cancer (RC) to radiotherapy. No biomarker is currently in clinical use to select patients for treatment modifications. Methods: We identified two cohorts o
Externí odkaz:
https://doaj.org/article/6732596b11c54a618ebd9beb8dd8725c
Autor:
Eugene F. Schuster, Elena Lopez-Knowles, Anastasia Alataki, Lila Zabaglo, Elizabeth Folkerd, David Evans, Kally Sidhu, Maggie Chon U. Cheang, Holly Tovey, Manuel Salto-Tellez, Perry Maxwell, John Robertson, Ian Smith, Judith M. Bliss, Mitch Dowsett
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Aromatase inhibitors (AIs) reduce recurrences and mortality in postmenopausal patients with oestrogen receptor positive (ER+) breast cancer (BC), but >20% of patients will eventually relapse. Given the limited understanding of intrinsic resi
Externí odkaz:
https://doaj.org/article/ac7abf0f898945ac9498001b487931f6
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4536-4539 (2023)
We propose that an information technology and computational framework that would unify access to hospital digital information silos, and enable integration of this information using machine learning methods, would bring a new paradigm to patient mana
Externí odkaz:
https://doaj.org/article/58c918b499144663b59de5646996928d
Autor:
Ashleigh C. Hamilton, Finian J. Bannon, Philip D. Dunne, Jacqueline James, Stephen McQuaid, Ronan T. Gray, Manuel Salto-Tellez, Chris R. Cardwell, Maurice B. Loughrey, Helen G. Coleman
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 3, Pp 347-359 (2023)
Background and Aims: The observed increase in the incidence of early-onset colorectal cancer (EOCRC) is being driven by sporadic cases, but the molecular characteristics of these tumors are not fully understood. Our objective was to investigate the p
Externí odkaz:
https://doaj.org/article/8d691786c5d14cfba3e309cbd980f469
Autor:
Fatima Abdullahi Sidi, Victoria Bingham, Stephen McQuaid, Stephanie G Craig, Richard C Turkington, Jacqueline A James, Matthew P Humphries, Manuel Salto-Tellez
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0289355 (2023)
BackgroundSmall bowel adenocarcinoma (SBA) is a rare malignancy of the small intestine associated with late stage diagnosis and poor survival outcome. High expression of immune cells and immune checkpoint biomarkers especially programmed cell death l
Externí odkaz:
https://doaj.org/article/5f9a60433250490786237291b3fb6863
Autor:
Stephanie G. Craig, Svenja Mende, Matthew P. Humphries, Victoria Bingham, Amélie Viratham Pulsawatdi, Maurice B. Loughrey, Helen G. Coleman, Stephen McQuaid, Richard H. Wilson, Sandra Van Schaeybroeck, Jacqueline A. James, Manuel Salto‐Tellez
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3317-3328 (2021)
Clinical trials for MET inhibitors have demonstrated limited success for their use in colon cancer (CC). However, clinical efficacy may be obscured by a lack of standardisation in MET assessment for patient stratification. In this study, we aimed to
Externí odkaz:
https://doaj.org/article/0b8be54a07784f57bd958f3c8b5f5b03
Autor:
Ross J Porter, Graeme I Murray, Abdo Alnabulsi, Matthew P Humphries, Jacqueline A James, Manuel Salto‐Tellez, Stephanie G Craig, Ji M Wang, Teizo Yoshimura, Mairi H McLean
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 5, Pp 495-506 (2021)
Abstract Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic effects including anti‐microbial and immunoregulatory f
Externí odkaz:
https://doaj.org/article/ba815979fd8d47278716bcad2a4d676c
Autor:
Eileen E. Parkes, Matthew P. Humphries, Elaine Gilmore, Fatima A. Sidi, Victoria Bingham, Su M. Phyu, Stephanie Craig, Catherine Graham, Joseph Miller, Daryl Griffin, Manuel Salto-Tellez, Stephen F. Madden, Richard D. Kennedy, Samuel F. Bakhoum, Stephen McQuaid, Niamh E. Buckley
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract STING signaling in cancer is a crucial component of response to immunotherapy and other anti-cancer treatments. Currently, there is no robust method of measuring STING activation in cancer. Here, we describe an immunohistochemistry-based ass
Externí odkaz:
https://doaj.org/article/6790f073307d4fffbb5fb02a2f06cc1f
Autor:
Aideen C. Roddy, Caitríona E. McInerney, Tom Flannery, Estelle G. Healy, James P. Stewart, Veronica J. Spence, Jamie Walsh, Manuel Salto-Tellez, Darragh G. McArt, Kevin M. Prise
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1219 (2023)
Glioblastoma (GBM) is the most prevalent and aggressive adult brain tumor. Despite multi-modal therapies, GBM recurs, and patients have poor survival (~14 months). Resistance to therapy may originate from a subpopulation of tumor cells identified as
Externí odkaz:
https://doaj.org/article/f0c8e8ffdc1141a29cf7ee38fcb6596a