Zobrazeno 1 - 10
of 539
pro vyhledávání: '"MANF"'
Autor:
Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)
Abstract Background The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer’s disease (AD) brain, but how ER stress contributes to the onset and development of AD remains poorly characterized. Mesencephali
Externí odkaz:
https://doaj.org/article/20c6378e6c59460e8cba23c7081061d4
Autor:
Haibin Dong, Wenjuan Jia, Chunxiao Wang, Da Teng, Bowen Xu, Xiaoning Ding, Jun Yang, Lin Zhong, Lei Gong
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Myocardial ischemia/reperfusion (I/R) injury is a common pathological process in clinical practice. Developing effective therapeutic strategies to reduce or prevent this injury is crucial. The article aimed to investigate the role
Externí odkaz:
https://doaj.org/article/5395fee3b91e4b62a385e3bbcb75be52
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 287, Iss , Pp 117331- (2024)
NLRP3 inflammasome activation in macrophages is involved in paraquat-induced acute lung injury (ALI). MANF exerts an inhibitory effect against inflammation and cell death. The aim of this study was to investigate the role of MANF in paraquat-stimulat
Externí odkaz:
https://doaj.org/article/445b156016f942d5af7e2b5bf7b67b23
Autor:
Wen Wen, Hui Li, Marisol Lauffer, Di Hu, Zuohui Zhang, Hong Lin, Yongchao Wang, Mariah Leidinger, Jia Luo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Excessive alcohol exposure can cause neurobehavioral deficits and structural alterations in the brain. Emerging research evidence suggests that endoplasmic reticulum (ER) stress plays an important role in alcohol-induced neurotoxicity. Mesencephalic
Externí odkaz:
https://doaj.org/article/946dcdc98bf44a4a80d8debac3b95baa
Autor:
Zabun Nahar, Delruba Tabassum Nowshin, A. S. M. Roknuzzaman, Md. Sohan, Salsabil Islam, M. M. A. Shalahuddin Qusar, Md. Rabiul Islam
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Major depressive disorder (MDD) is a debilitating health condition that has significant morbidity and mortality rates. Depression can be caused due to social, biological, environmental, psychological, and genetic factors. A few bi
Externí odkaz:
https://doaj.org/article/f43bb6b2c2294e12ace59b9b49a9d744
Autor:
Huiyuan Xie, Haiyan Deng, Xiaoping Yang, Xianxian Gao, Shanru Yang, Weiyi Chen, Yixuan Wang, Naibin Yang, Liang Yong, Xin Hou
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 3, Pp 101360- (2024)
Background & Aims: The immune tolerance induced by hepatitis B virus (HBV) is a major challenge for achieving effective viral clearance, and the mechanisms involved are not well-understood. One potential factor involved in modulating immune responses
Externí odkaz:
https://doaj.org/article/c22f1c30883a4761b15e51701a3fa5e8
Akademický článek
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Autor:
Emmi Pakarinen, Päivi Lindholm
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by gradual loss of midbrain dopamine neurons, leading to impaired motor function. Preclinical studies have indicated cerebral dopamine neurotrophic factor (CDNF) and
Externí odkaz:
https://doaj.org/article/ab1e912e62f74c58aa680c30a2f99210
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-11 (2022)
Abstract Background Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis. Redistribution of the ER/SR proteome can have deleterious effects
Externí odkaz:
https://doaj.org/article/fd93747235684bd5a467c03348f87f42