Analyzing Mass Spectrometry Imaging Data of 13C-Labeled Phospholipids in Camelina sativa and Thlaspi arvense (Pennycress) Embryos

Autor: Trevor B. Romsdahl, Shrikaar Kambhampati, Somnath Koley, Umesh P. Yadav, Ana Paula Alonso, Doug K. Allen, Kent D. Chapman

Publikováno v: Metabolites, Vol 11, Iss 3, p 148 (2021)

The combination of 13C-isotopic labeling and mass spectrometry imaging (MSI) offers an approach to analyze metabolic flux in situ. However, combining isotopic labeling and MSI presents technical challenges ranging from sample preparation, label incor

Externí odkaz: https://doaj.org/article/0fb36badf264419e950775ecd903cc2c

Lipid analysis by ion mobility spectrometry combined with mass spectrometry: A brief update with a perspective on applications in the clinical laboratory

Autor: Joshua Dubland

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 23, Iss, Pp 7-13 (2022)

Ion mobility spectrometry (IMS) is an analytical technique where ions are separated in the gas phase based on their mobility through a buffer gas in the presence of an electric field. An ion passing through an IMS device has a characteristic collisio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae14ffaafac42c15bc615e2dc76a45d
http://europepmc.org/articles/PMC8703053

Direct detection of OXA-48-like carbapenemase variants with and without co-expression of an extended-spectrum β-lactamase from bacterial cell lysates using mass spectrometry

Autor: Scott R. Kronewitter, James L. Stephenson, Arvind Verma, William M. McGee, Jason R. Neil, Marjaana Viirtola

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 25-34 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • LC-MS methods are used to identify intact OXA-48 like enzymes from bacterial lysates. • Individual protein variants of the OXA-48 like carbapenemases can be detected with tandem mass spectrometry. • OXA-48 like carbapenemases can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7805096e04f78395d3d7e73173308107
http://www.sciencedirect.com/science/article/pii/S2667145X21000080

Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy

Autor: Sten Ohlson, Minh-Dao Duong-Thi, Anandalakshmi Venkatraman, Konstantin Pervushin, Jodhbir S. Mehta

Publikováno v: Journal of Advanced Research, Vol 24, Iss, Pp 529-543 (2020)
Journal of Advanced Research

Graphical abstract
Highlights • Corneal stromal dystrophies are a group of hereditary disorders caused by mutations in the TGFBI gene and affect the corneal stroma and epithelium. • The disease is characterized by the accumulation of insolub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ba3b1d04347c4a9bdcc95cfce96a0b
http://www.sciencedirect.com/science/article/pii/S2090123220300953

DNA polymerases η and κ bypass N

Autor: Pratibha P, Ghodke, F Peter, Guengerich

Publikováno v: The Journal of Biological Chemistry

DNA-protein cross-links are formed when proteins become covalently trapped with DNA in the presence of exogenous or endogenous alkylating agents. If left unrepaired, they inhibit transcription as well as DNA unwinding during replication and may resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12da75175a6f1d5dc67c70d562210114
https://pubmed.ncbi.nlm.nih.gov/34461101