Zobrazeno 1 - 10
of 21
pro vyhledávání: '"MALAY CHOUDHURY"'
Autor:
Amjad N. Kanj, Theodore J. Kottom, Kyle J. Schaefbauer, Malay Choudhury, Andrew H. Limper, Joseph H. Skalski
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-5 (2023)
Abstract Background The gut-lung axis is the concept that alterations of gut microbiota communities can influence immune function in the lungs. While studies have explored the relationship between intestinal bacterial dysbiosis and asthma development
Externí odkaz:
https://doaj.org/article/68f80954005844aaaa420192932489f1
Autor:
Michael H. Bourne, Theodore J. Kottom, Deanne M. Hebrink, Malay Choudhury, Edward B. Leof, Andrew H. Limper
Publikováno v:
Cells, Vol 10, Iss 12, p 3502 (2021)
Idiopathic pulmonary fibrosis (IPF) remains an intractably fatal disorder, despite the recent advent of anti-fibrotic medication. Successful treatment of IPF, like many chronic diseases, may benefit from the concurrent use of multiple agents that exh
Externí odkaz:
https://doaj.org/article/424669b0d6514c3a827bae4b184b79a0
Autor:
Malay Choudhury, Kyle J. Schaefbauer, Theodore J. Kottom, Eunhee S. Yi, Daniel J. Tschumperlin, Andrew H. Limper
The neutral amino acid glutamine plays a central role in TGF-β-induced myofibroblast activation and differentiation. Cells take up glutamine mainly through a transporter expressed on the cell surface known as solute carrier SLC1A5. In this current w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e751a754c8727c1d59be544ec18144f1
https://doi.org/10.1101/2022.05.23.493168
https://doi.org/10.1101/2022.05.23.493168
Autor:
Malay Choudhury, Kyle J. Schaefbauer, Xueqian Yin, Jeong Han Kang, Edward B. Leof, Andrew H. Limper, Theodore J. Kottom, Bhaskar Roy
Publikováno v:
The FASEB Journal. 34:8920-8940
In the current work we show that the profibrotic actions of TGF-β are mediated, at least in part, through a metabolic maladaptation in glutamine metabolism and how the inhibition of glutaminase 1 (GLS1) reverses pulmonary fibrosis. GLS1 was found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841651646f140d706549a50e7cf69f07
https://doi.org/10.1096/fj.202000564r
https://doi.org/10.1096/fj.202000564r
Autor:
AMJAD N KANJ, THEODORE KOTTOM, KYLE SCHAEFBAUER, MALAY CHOUDHURY, ANDREW H LIMPER, JOSEPH H SKALSKI
Publikováno v:
Chest. 162:A2634
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f75bb3d66a99f62502ede7c951a03b
https://doi.org/10.1016/j.chest.2022.08.2151
https://doi.org/10.1016/j.chest.2022.08.2151
Autor:
Xueqian Yin, Andrew H. Limper, Jeong Han Kang, Edward B. Leof, Mahefatiana Andrianifahanana, Malay Choudhury, Danielle M. Hernandez
Publikováno v:
FASEB J
Pathogenic fibrotic diseases, including Idiopathic Pulmonary Fibrosis (IPF), have some of the worst prognoses and affect millions of people worldwide. With unclear etiology and minimally effective therapies, two-thirds of IPF patients die within 2-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e6e8d3c71dd1f73317acfd81433cd7
https://europepmc.org/articles/PMC7136152/
https://europepmc.org/articles/PMC7136152/
Autor:
Mahefatiana Andrianifahanana, Mi-Yeon Jung, Edward B. Leof, Kyle J. Schaefbauer, Xueqian Yin, Danielle M. Hernandez, Jeong Han Kang, Malay Choudhury
Publikováno v:
Science Signaling. 12
Metabolic dysregulation in fibroblasts is implicated in the profibrotic actions of transforming growth factor-β (TGF-β). Here, we present evidence that hexokinase 2 (HK2) is important for mediating the fibroproliferative activity of TGF-β both in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4d0e4eeca3251c4fafe7f252989621
https://doi.org/10.1126/scisignal.aax4067
https://doi.org/10.1126/scisignal.aax4067
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(2)
Transforming growth factor-beta (TGFβ) is an enigmatic protein with various roles in healthy tissue homeostasis/development as well as the development or progression of cancer, wound healing, fibrotic disorders, and immune modulation, to name a few.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523ad692b5cb26960cc22d1e1f39123a
https://pubmed.ncbi.nlm.nih.gov/31907984
https://pubmed.ncbi.nlm.nih.gov/31907984
Autor:
Malay Choudhury, Anup Kumar, Shashank Choudhary, Kaushal Kishore, T. Thirumurgan, Vinay Sanjay Gujre, Manashi Adhikary, Mukesh Vishwakarma, Amey Sanjay Gujre
Publikováno v:
Engineering Failure Analysis. 115:104666
Crane hooks are the safety–critical component which are extensively used for material handling in manufacturing units. Any failure of such component may lead to casualty in workplace apart from loss of productivity. Current work presents analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::330d097164f22287953a32f80db8625c
https://doi.org/10.1016/j.engfailanal.2020.104666
https://doi.org/10.1016/j.engfailanal.2020.104666
Autor:
Edward B. Leof, Malay Choudhury, Mi-Yeon Jung, Xueqian Yin, Mahefatiana Andrianifahanana, Jeong Han Kang
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab5a49327e3811f0c8f36094170a9c58
https://doi.org/10.1096/fasebj.2018.32.1_supplement.533.3
https://doi.org/10.1096/fasebj.2018.32.1_supplement.533.3