Zobrazeno 1 - 10
of 385
pro vyhledávání: '"MAKOTO NAKANISHI"'
Autor:
Wenwen Wu, Jing Zhu, Naoe Taira Nihira, Yukiko Togashi, Atsushi Goda, Junki Koike, Kiyoshi Yamaguchi, Yoichi Furukawa, Takuya Tomita, Yasushi Saeki, Yoshikazu Johmura, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Epigenetic dysregulation affecting oncogenic transcription and DNA damage response is a hallmark of cancer. The histone demethylase KDM4B, a factor regulating these processes, plays important roles in estrogen receptor-mediated tr
Externí odkaz:
https://doaj.org/article/495f1b5e342f41eeacc7052e5521f4b0
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Nao Shiraishi, Tsuyoshi Konuma, Yoshie Chiba, Sayaka Hokazono, Nao Nakamura, Md Hadiul Islam, Makoto Nakanishi, Atsuya Nishiyama, Kyohei Arita
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract DNA methylation maintenance is essential for cell fate inheritance. In differentiated cells, this involves orchestrated actions of DNMT1 and UHRF1. In mice, the high-affinity binding of DPPA3 to the UHRF1 PHD finger regulates UHRF1 chromatin
Externí odkaz:
https://doaj.org/article/92681e5b48734fd3a2dd131edcc20335
Autor:
Xinyi Zeng, Teh-Wei Wang, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Yoshikazu Johmura, Makoto Nakanishi
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101943- (2024)
Objectives: Adipose tissue is an endocrine and energy storage organ composed of several different cell types, including mature adipocytes, stromal cells, endothelial cells, and a variety of immune cells. Adipose tissue aging contributes to the pathog
Externí odkaz:
https://doaj.org/article/d4df8a00e52b49dc89a15ccb72df509b
Autor:
Amika Kikuchi, Hiroki Onoda, Kosuke Yamaguchi, Satomi Kori, Shun Matsuzawa, Yoshie Chiba, Shota Tanimoto, Sae Yoshimi, Hiroki Sato, Atsushi Yamagata, Mikako Shirouzu, Naruhiko Adachi, Jafar Sharif, Haruhiko Koseki, Atsuya Nishiyama, Makoto Nakanishi, Pierre-Antoine Defossez, Kyohei Arita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
DNMT1 is an essential for maintaining genomic DNA methylation. Here, we report the cryo-EM structure of DNMT1 bound to ubiquitinated H3 and hemimethylated DNA, revealing structural insight into the activation mechanism of DNMT1.
Externí odkaz:
https://doaj.org/article/23f99d987e204714bbc9195fcfc9a571
Autor:
Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Keiko Katoh, Kaori Saitoh, Takamasa Ishikawa, Tomoyoshi Soga, Yasuhito Nannya, Makoto Nakanishi, Daiju Kitagawa, Toshio Kitamura, Susumu Goyama
Publikováno v:
HemaSphere, Vol 7, p e20270ec (2023)
Externí odkaz:
https://doaj.org/article/f87f3d9fc84c4f848d07dfb6e3f8b97e
Autor:
Makoto Nakanishi, Junichi Soma
Publikováno v:
Poultry Science, Vol 102, Iss 5, Pp 102612- (2023)
ABSTRACT: Infectious bronchitis, an acute and highly contagious disease that affects chickens, is caused by the infectious bronchitis virus (IBV). The antigenic variant QX-like IBV was first reported in China in 1996 and is now endemic in many countr
Externí odkaz:
https://doaj.org/article/7f545b95d28a48eb9979d834ef3764be
Autor:
Katsunori Tamura, Yuri Oshima, Yuta Fuse, Noriyuki Nagaoka, Tatsuki Kunoh, Makoto Nakanishi, Tatsuo Fujii, Tokuro Nanba, Jun Takada
Publikováno v:
ACS Omega, Vol 7, Iss 15, Pp 12795-12802 (2022)
Externí odkaz:
https://doaj.org/article/9f1abc80b17a4789a0daa3ddb38154ef
Autor:
Yuto Baba, Takeo Kosaka, Hiroaki Kobayashi, Kohei Nakamura, Shuji Mikami, Hiroshi Nishihara, Makoto Nakanishi, Mototsugu Oya
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Background The use of whole-genome sequencing in clinical practice has revealed variable genomic characteristics across cancer types, one of which is whole-genome doubling (WGD), which describes the duplication of a complete set of chromosom
Externí odkaz:
https://doaj.org/article/5c0715b0b2974202a6c551149e8c58d5
Autor:
Ryota Miyashita, Atsuya Nishiyama, Weihua Qin, Yoshie Chiba, Satomi Kori, Norie Kato, Chieko Konishi, Soichiro Kumamoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoshitaka Kawasoe, Toshiki Tsurimoto, Tatsuro S Takahashi, Heinrich Leonhardt, Kyohei Arita, Makoto Nakanishi
Publikováno v:
eLife, Vol 12 (2023)
UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation of PAF15 (PAF15Ub2), which regulates the localization and activation of DNMT1 at DNA methy
Externí odkaz:
https://doaj.org/article/d7c74f44e17c4bfa90ecba39af08c77b