High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

Autor: Hughes, Rebecca E., Elliott, Richard J.R., Munro, Alison F., Makda, Ashraff, O’Neill, J. Robert, Hupp, Ted, Carragher, Neil O. ^*

Publikováno v: In SLAS Discovery August 2020 25(7):770-782

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sj-pdf-1-jbx-10.1177_24725552211019405 – Supplemental material for Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients

Autor: Marwick, John A., Elliott, Richard J. R., Longden, James, Makda, Ashraff, Hirani, Nik, Dhaliwal, Kevin, Dawson, John C., Carragher, Neil O.

Supplemental material, sj-pdf-1-jbx-10.1177_24725552211019405 for Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients by John A. Marwick, Ric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a945102b91ddb4b921af5ef8002940e

Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin-Targeting Thiazole Analogue of Bisebromoamide

Autor: Johnston, Heather J., Boys, Sarah K., Makda, Ashraff, Carragher, Neil O., Hulme, Alison N.

Publikováno v: Johnston, H J, Boys, S K, Makda, A, Carragher, N O & Hulme, A N 2016, ' Naturally Inspired Peptide Leads: Alanine Scanning Reveals an Actin-Targeting Thiazole Analogue of Bisebromoamide ', ChemBioChem, vol. 17, no. 17, pp. 1621-1627 . https://doi.org/10.1002/cbic.201600257
Chembiochem

Systematic alanine-scanning of the linear peptide bisebromoamide (BBA), isolated from a marine cyanobacterium, is enabled by targeting the solid phase peptide synthesis of thiazole analogues. The synthetic Tz-BBA analogues have comparable cytotoxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7c13e447bab028b125aba2394d22c889
https://hdl.handle.net/20.500.11820/6aebd544-b887-45ac-807d-658ca0a4a3df

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