Zobrazeno 1 - 10
of 785
pro vyhledávání: '"MAINI, P. K."'
Real-world cellular invasion processes often take place in curved geometries. Such problems are frequently simplified in models to neglect the curved geometry in favour of computational simplicity, yet doing so risks inaccuracy in any model-based pre
Externí odkaz:
http://arxiv.org/abs/2406.08291
Autor:
Villa, Chiara, Maini, Philip K, Browning, Alexander P, Jenner, Adrianne L, Hamis, Sara, Cassidy, Tyler
Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in disease progression and treatment failure. Accordingly, there has been increasing interest in the development of mathematical models capable of capturing its role
Externí odkaz:
http://arxiv.org/abs/2406.01505
Autor:
Lamirande, Patricia, Gaffney, Eamonn A., Gertz, Michael, Maini, Philip K., Crawshaw, Jessica R., Caruso, Antonello
Publikováno v:
Invest Ophthalmol Vis Sci. 2024;65(12):21
Purpose: Standard of care for various retinal diseases involves recurrent intravitreal injections. This motivates mathematical modelling efforts to identify influential factors for drug residence time, aiming to minimise administration frequency. We
Externí odkaz:
http://arxiv.org/abs/2404.04086
This study investigates transient wave dynamics in Turing pattern formation, focusing on waves emerging from localised disturbances. While the traditional focus of diffusion-driven instability has primarily centred on stationary solutions, considerab
Externí odkaz:
http://arxiv.org/abs/2403.09247
Autor:
Jiménez-Sánchez, Juan, Ortega-Sabater, Carmen, Maini, Philip K., Pérez-García, Víctor M., Lorenzi, Tommaso
Evolvability is defined as the ability of a population to generate heritable variation to facilitate its adaptation to new environments or selection pressures. In this article, we consider evolvability as a phenotypic trait subject to evolution and d
Externí odkaz:
http://arxiv.org/abs/2402.06392
In this work we develop a homogenisation methodology to upscale mathematical descriptions of microcirculatory blood flow from the microscale (where individual vessels are resolved) to the macroscopic (or tissue) scale. Due to the assumed two-phase na
Externí odkaz:
http://arxiv.org/abs/2401.10932
A fundamental feature of collective cell migration is phenotypic heterogeneity which, for example, influences tumour progression and relapse. While current mathematical models often consider discrete phenotypic structuring of the cell population, in-
Externí odkaz:
http://arxiv.org/abs/2401.07279
Publikováno v:
Physical Review E 108, 054407 (2023)
Complex biological processes involve collective behavior of entities (bacteria, cells, animals) over many length and time scales and can be described by discrete models that track individuals or by continuum models involving densities and fields. We
Externí odkaz:
http://arxiv.org/abs/2311.09080
Interstitial fluid flow is a feature of many solid tumours. In vitro Experiments have shown that such fluid flow can direct tumour cell movement upstream or downstream depending on the balance between the competing mechanisms of tensotaxis and autolo
Externí odkaz:
http://arxiv.org/abs/2309.13982
When employing mechanistic models to study biological phenomena, practical parameter identifiability is important for making accurate predictions across wide range of unseen scenarios, as well as for understanding the underlying mechanisms. In this w
Externí odkaz:
http://arxiv.org/abs/2309.01476