Zobrazeno 1 - 10
of 682
pro vyhledávání: '"MAGL"'
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Monoacylglycerol lipase (MAGL) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG) hydrolysis, converting monoacylglycerol (MAG) into free fatty acids and glycerol. Results In thi
Externí odkaz:
https://doaj.org/article/d5b7d143a06e49ea8962dc552796de4a
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 2143-2167 (2024)
Hongqing Zhao,1,2,* Yang Liu,1,2,* Na Cai,3 Xiaolin Liao,1,2 Lin Tang,2,4 Yuhong Wang1,2 1Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Hunan Key Laboratory of Tr
Externí odkaz:
https://doaj.org/article/1fc5f01ea3c946d9b6a6921f4163274d
Autor:
Alexis F. League, Barkha J. Yadav-Samudrala, Ramya Kolagani, Calista A. Cline, Ian R. Jacobs, Jonathan Manke, Micah J. Niphakis, Benjamin F. Cravatt, Aron H. Lichtman, Bogna M. Ignatowska-Jankowska, Sylvia Fitting
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundHuman immunodeficiency virus (HIV) affects nearly 40 million people globally, with roughly 80% of all people living with HIV receiving antiretroviral therapy. Antiretroviral treatment suppresses viral load in peripheral tissues but does not
Externí odkaz:
https://doaj.org/article/8c79ef5970b94294a9b7f4e26a0627ff
Autor:
Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli
Publikováno v:
Cells, Vol 13, Iss 10, p 830 (2024)
The inhibition of endocannabinoid hydrolysis by enzymatic inhibitors may interfere with mechanisms underlying migraine-related pain. The dual FAAH/MAGL inhibitor AKU-005 shows potent inhibitory activity in vitro. Here, we assessed the effect of AKU-0
Externí odkaz:
https://doaj.org/article/a456cb7e44b14148aada90eee6b60749
Autor:
Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz
Publikováno v:
JHEP Reports, Vol 5, Iss 8, Pp 100794- (2023)
Background & Aims: Liver regeneration is a repair process in which metabolic reprogramming of parenchymal and inflammatory cells plays a major role. Monoacylglycerol lipase (MAGL) is an ubiquitous enzyme at the crossroad between lipid metabolism and
Externí odkaz:
https://doaj.org/article/346571883a5f4eb1b52cd8a45a9591b1
Akademický článek
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Akademický článek
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Autor:
Erika Liktor-Busa, Aidan A. Levine, Seph M. Palomino, Simar Singh, Jared Wahl, Todd W. Vanderah, Nephi Stella, Tally M. Largent-Milnes
Publikováno v:
Frontiers in Pain Research, Vol 4 (2023)
IntroductionThe high prevalence and severe symptoms of migraines in humans emphasizes the need to identify underlying mechanisms that can be targeted for therapeutic benefit. Clinical Endocannabinoid Deficiency (CED) posits that reduced endocannabino
Externí odkaz:
https://doaj.org/article/d4532d8037154f8e87e75dc035f497b3
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Autor:
Corina Andrei, Dragos Paul Mihai, Georgiana Nitulescu, Anca Ungurianu, Denisa Marilena Margina, George Mihai Nitulescu, Octavian Tudorel Olaru, Radu Mihai Busca, Anca Zanfirescu
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1563 (2023)
Osteoarthritis is characterized by progressive articular cartilage degradation, subchondral bone changes, and synovial inflammation, and affects various joints, causing pain and disability. Current osteoarthritis therapies, primarily focused on pain
Externí odkaz:
https://doaj.org/article/5294a96fb3a6425c9ae54eb18d75cc87