Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage

Autor: Zhi Zuo, Jian-Xiao Shen, Yan Pan, Juan Pu, Yong-Gang Li, Xing-hua Shao, Wan-Peng Wang

Publikováno v: Cellular Physiology and Biochemistry, Vol 51, Iss 1, Pp 244-261 (2018)

Background/Aims: Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes associated with podocyte injury in chronic kidney disease (CKD) by weighted gene correlation

Externí odkaz: https://doaj.org/article/94144e3214c641049766b0f7cbbfc6fc

MAGI2 Gene Region and Celiac Disease

Autor: Amaia Jauregi-Miguel, Izortze Santin, Koldo Garcia-Etxebarria, Ane Olazagoitia-Garmendia, Irati Romero-Garmendia, Maialen Sebastian-delaCruz, Iñaki Irastorza, Spanish Consortium for the Genetics of Celiac Disease, Ainara Castellanos-Rubio, Jose Ramón Bilbao

Publikováno v: Frontiers in Nutrition, Vol 6 (2019)

Celiac disease (CD) patients present a loss of intestinal barrier function due to structural alterations in the tight junction (TJ) network, the most apical unions between epithelial cells. The association of TJ-related gene variants points to an imp

Externí odkaz: https://doaj.org/article/59193204e3404c659d3ab3fdb52d1104

A New Story of the Three Magi: Scaffolding Proteins and lncRNA Suppressors of Cancer

Autor: Eric Chastre, Larissa Kotelevets

Publikováno v: Cancers
Cancers, 2021, 13 (17), pp.4264. ⟨10.3390/cancers13174264⟩
Cancers, MDPI, 2021, 13 (17), pp.4264. ⟨10.3390/cancers13174264⟩
Cancers, Vol 13, Iss 4264, p 4264 (2021)

Simple Summary MAGI1, 2, and 3 belong to a subgroup of the MAGUK family of scaffolding proteins, and are comprised of 6 PDZ domains, 2 WW domains, and 1 GUK domain. MAGIs associate with cell surface receptors, junctional complexes, and interact selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bc1ebd70a89387dbcb56d89c13e937
https://pubmed.ncbi.nlm.nih.gov/34503076

MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2

Autor: Shu Guan, Feng Jin, Miao He, Jing Zhang, Haishan Zhao, Mengtao Ma, Qiuchen Chen, Yuanyuan Yan, Zhaojin Yu, Mingli Sun, Qian Jiang, Weifan Yao, Minjie Wei

Publikováno v: International Journal of Biological Sciences

Tumor metastasis is a complex and multistep process and its exact molecular mechanisms remain unclear. We attempted to find novel microRNAs (miRNAs) contributing to the migration and invasion of breast cancer cells. In this study, we found that the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b2b80f437476a58cba06a9021ab209
http://europepmc.org/articles/PMC8495405

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