beta-Catenin-TCF/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation

Autor: Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, Lozano-Asencio C, Benoukraf T, Tirado-Magallanes R, Zhou Q, Burocziova M, Rahmatova S, Pytlik R, Brdicka T, Tenen D, Korinek V, Alberich-Jorda M

Publikováno v: BLOOD
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The canonical Wnt signaling pathway is mediated by interaction of beta-catenin with the T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) transcription factors and subsequent transcription activation of Wnt-target genes. In the hematopoietic s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::9cf4f77c8be796aa092ddafc72122dc1
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15173

Analysis of clinically relevant variants from ancestrally diverse Asian genomes.

Autor: Chan SH; Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore., Bylstra Y; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore., Teo JX; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore., Kuan JL; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore., Bertin N; Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Gonzalez-Porta M; Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Hebrard M; Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Tirado-Magallanes R; Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Tan JHJ; Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Jeyakani J; Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Li Z; Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore., Chong YS; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Singapore Institute for Clinical Sciences, Singapore, 117609, Singapore., Davila S; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore., Goh LL; Personalized Medicine Service, Tan Tock Seng Hospital, Singapore, 308433, Singapore., Lee ES; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.; National Healthcare Group Polyclinics, Singapore, 138543, Singapore., Wong E; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore., Prabhakar S; Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Liu J; Human Genomics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Eisenhaber B; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore., Karnani N; Human Development, Singapore Institute for Clinical Sciences, Singapore, 117609, Singapore.; Clinical Data Engagement, Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore., Leong KP; Personalized Medicine Service, Tan Tock Seng Hospital, Singapore, 308433, Singapore.; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, 308433, Singapore., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore., Yeo KK; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore.; Department of Cardiology, National Heart Centre Singapore, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, 169857, Singapore., Chambers JC; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.; Precision Health Research Singapore (PRECISE), Singapore, 139234, Singapore.; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Duke-NUS Medical School, Singapore, 169857, Singapore.; Precision Health Research Singapore (PRECISE), Singapore, 139234, Singapore., Tan P; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore. patrick.tan@precise.cris.sg.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore. patrick.tan@precise.cris.sg.; Precision Health Research Singapore (PRECISE), Singapore, 139234, Singapore. patrick.tan@precise.cris.sg.; Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore. patrick.tan@precise.cris.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. patrick.tan@precise.cris.sg., Jamuar SS; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore. Saumya.S.Jamuar@singhealth.com.sg.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore. Saumya.S.Jamuar@singhealth.com.sg.; Genetics Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, 229899, Singapore. Saumya.S.Jamuar@singhealth.com.sg.; Paediatric Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857, Singapore. Saumya.S.Jamuar@singhealth.com.sg., Ngeow J; Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore. joanne.ngeow@ntu.edu.sg.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857, Singapore. joanne.ngeow@ntu.edu.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore. joanne.ngeow@ntu.edu.sg.; Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, 138673, Singapore. joanne.ngeow@ntu.edu.sg., Lim WK; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore. wengkhong.lim@duke-nus.edu.sg.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore. wengkhong.lim@duke-nus.edu.sg.; Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore. wengkhong.lim@duke-nus.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 05; Vol. 13 (1), pp. 6694. Date of Electronic Publication: 2022 Nov 05.

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution.

Autor: Yoon J; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Grinchuk OV; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kannan S; Biomolecular Modeling and Design Division, Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore 138671, Singapore., Ang MJY; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.; NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore 119077, Singapore., Li Z; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Tay EXY; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lok KZ; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lee BWL; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chuah YH; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chia K; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tirado Magallanes R; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore., Liu C; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Zhao H; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Hor JH; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore , Singapore., Lim JJ; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore., Benoukraf T; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada., Toh TB; The N.1 Institute for Health, National University of Singapore, Singapore , Singapore.; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chow EK; Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore., Kovalik JP; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 169857, Singapore., Ching J; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 169857, Singapore., Ng SY; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore , Singapore.; National Neuroscience Institute, Singapore 308433, Singapore., Koh MJ; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Liu X; Department of Chemistry, National University of Singapore, Singapore 117543, Singapore., Verma CS; Biomolecular Modeling and Design Division, Bioinformatics Institute, A*STAR (Agency for Science, Technology and Research), Singapore 138671, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Ong DST; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore , Singapore.; National Neuroscience Institute, Singapore 308433, Singapore.

Publikováno v: Science advances [Sci Adv] 2021 Sep 03; Vol. 7 (36), pp. eabf6033. Date of Electronic Publication: 2021 Sep 03.

The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.

Autor: Lee KK; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. A0123884@u.nus.edu., Rajagopalan D; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Bhatia SS; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tirado-Magallanes R; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore, Singapore., Jha S; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csisjha@nus.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. csisjha@nus.edu.sg.

Publikováno v: Cell death discovery [Cell Death Discov] 2021 May 07; Vol. 7 (1), pp. 95. Date of Electronic Publication: 2021 May 07.

Japanese encephalitis virus-induced DNA methylation contributes to blood-brain barrier permeability by modulating tight junction protein expression.

Autor: Xiang, Xiao^1,2 (AUTHOR), Yu, Du¹ (AUTHOR), Li, Zhuangzhuang¹ (AUTHOR), Fros, Jelke J.² (AUTHOR), Wei, Jianchao¹ (AUTHOR), Liu, Ke¹ (AUTHOR), Li, Zongjie¹ (AUTHOR), Shao, Donghua¹ (AUTHOR), Li, Beibei¹ (AUTHOR), Kortekaas, Jeroen² (AUTHOR), van Oers, Monique M.² (AUTHOR), Ma, Zhiyong¹ (AUTHOR), Pijlman, Gorben P.² (AUTHOR) gorben.pijlman@wur.nl, Qiu, Yafeng¹ (AUTHOR) yafengq@shvri.ac.cn

Publikováno v: Journal of Neuroinflammation. 10/28/2024, Vol. 21 Issue 1, p1-19. 19p.