Zobrazeno 1 - 10
of 4 280
pro vyhledávání: '"MACCHIA, M."'
Autor:
Khoury, L. El, Jing, Z., Cuzzolin, A., Deplano, A., Loco, D., Sattarov, B., Hédin, F., Wendeborn, S., Ho, C., Ahdab, D. El, Inizan, T. Jaffrelot, Sturlese, M., Sosic, A., Volpiana, M., Lugato, A., Barone, M., Gatto, B., Macchia, M. Ludovica, Bellanda, M., Battistutta, R., Salata, C., Kondratov, I., Iminov, R., Khairulin, A., Mykhalonok, Y., Pochepko, A., Chashka-Ratushnyi, V., Kos, I., Moro, S., Montes, M., Ren, P., Ponder, J. W., Lagardère, L., Piquemal, J. -P., Sabbadin, D.
Publikováno v:
Chem. Sci., 2022,13, 3674-3687
We report a fast-track computationally-driven discovery of new SARS-CoV2 Main Protease (M$^{pro}$) inhibitors whose potency range from mM for initial non-covalent ligands to sub-$\mu$M for the final covalent compound (IC50=830 +/- 50 nM). The project
Externí odkaz:
http://arxiv.org/abs/2110.05427
Autor:
Di Stefano M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Galati S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Lonzi C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Granchi C; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Poli G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Tuccinardi T; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address: tiziano.tuccinardi@unipi.it., Macchia M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Publikováno v:
International journal of pharmaceutics [Int J Pharm] 2024 Dec 05; Vol. 666, pp. 124817. Date of Electronic Publication: 2024 Oct 09.
Autor:
Di Stefano M; Department of Pharmacy, University of Pisa, Pisa, Italy.; Department of Life Sciences, University of Siena, Siena, Italy., Galati S; Department of Pharmacy, University of Pisa, Pisa, Italy., Piazza L; Department of Pharmacy, University of Pisa, Pisa, Italy., Gado F; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy., Granchi C; Department of Pharmacy, University of Pisa, Pisa, Italy., Macchia M; Department of Pharmacy, University of Pisa, Pisa, Italy., Giordano A; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.; Department of Medical Biotechnologies, University of Siena, Siena, Italy., Tuccinardi T; Department of Pharmacy, University of Pisa, Pisa, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA., Poli G; Department of Pharmacy, University of Pisa, Pisa, Italy.
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2356179. Date of Electronic Publication: 2024 Jun 12.
Autor:
Cuffaro D; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy., Bertolini A; Department of Surgical, Medical and Molecular Pathology and Critical Care Area, University of Pisa, 56126 Pisa, Italy., Silva AM; REQUIMTE/LAQV, ISEP, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal., Rodrigues F; REQUIMTE/LAQV, ISEP, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal., Gabbia D; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 351131 Padova, Italy., De Martin S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 351131 Padova, Italy., Saba A; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy.; Department of Surgical, Medical and Molecular Pathology and Critical Care Area, University of Pisa, 56126 Pisa, Italy.; Center for Instrument Sharing of the University of Pisa (CISUP), 56126 Pisa, Italy., Bertini S; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Digiacomo M; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy.; Center for Instrument Sharing of the University of Pisa (CISUP), 56126 Pisa, Italy., Macchia M; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy.
Publikováno v:
Foods (Basel, Switzerland) [Foods] 2024 Oct 18; Vol. 13 (20). Date of Electronic Publication: 2024 Oct 18.
Autor:
de Cesare, R.
Publikováno v:
Aevum, 1972 Jan 01. 46(1/2), 177-178.
Externí odkaz:
https://www.jstor.org/stable/25821096
Autor:
Cuffaro D; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy., Palladino P; Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia, 3, 50019 Sesto Fiorentino (FI), Italy. Electronic address: pasquale.palladino@unifi.it., Digiacomo M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy. Electronic address: maria.digiacomo@unipi.it., Bertini S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Minunni M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Macchia M; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy.
Publikováno v:
Food chemistry [Food Chem] 2025 Jan 15; Vol. 463 (Pt 4), pp. 141505. Date of Electronic Publication: 2024 Oct 03.
Autor:
Gentili V; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, Italy., Beltrami S; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, Italy., Cuffaro D; Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy., Cianci G; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, Italy., Maini G; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, Italy., Rizzo R; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, Italy.; Clinical Research Center, LTTA, University of Ferrara, Ferrara, Italy., Macchia M; Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy., Rossello A; Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy., Bortolotti D; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, Italy. brtdra@unife.it., Nuti E; Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy. elisa.nuti@unipi.it.
Publikováno v:
Pharmacological reports : PR [Pharmacol Rep] 2024 Sep 18. Date of Electronic Publication: 2024 Sep 18.
Autor:
Barbalace MC; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy., Freschi M; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.; Biostatistics and Clinical Trials Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', 47014 Meldola, Italy., Rinaldi I; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy., Zallocco L; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy., Malaguti M; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy., Manera C; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Ortore G; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Zuccarini M; Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy., Ronci M; Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.; COIIM-Interuniversitary Consortium for Engineering and Medicine, 86100 Campobasso, Italy., Cuffaro D; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy., Macchia M; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy., Hrelia S; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy., Giusti L; School of Pharmacy, University of Camerino, 62032 Camerino, Italy., Digiacomo M; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy., Angeloni C; Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.
Publikováno v:
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Sep 03; Vol. 13 (9). Date of Electronic Publication: 2024 Sep 03.
Autor:
Cuffaro D; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551., Burkhard T; Department of Biochemical and Physiological Sciences, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey Edward Jenner Building Guildford GU2 7XH UK s.santamaria@surrey.ac.uk., Bernardoni BL; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551., Di Leo R; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551., Zhang X; Institute of Cardiovascular Science, University College London 51 Chenies Mews London WC1E 6HX UK R.deGroot@ucl.ac.uk +44 (0) 20 3108 1423., Galati S; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551., Tuccinardi T; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551., Macchia M; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551., Rossello A; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551., Santamaria S; Department of Biochemical and Physiological Sciences, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey Edward Jenner Building Guildford GU2 7XH UK s.santamaria@surrey.ac.uk., de Groot R; Institute of Cardiovascular Science, University College London 51 Chenies Mews London WC1E 6HX UK R.deGroot@ucl.ac.uk +44 (0) 20 3108 1423., Nuti E; Department of Pharmacy, University of Pisa Via Bonanno 6 56126 Pisa Italy elisa.nuti@unipi.it +39 0502219551.
Publikováno v:
RSC medicinal chemistry [RSC Med Chem] 2024 Jun 19; Vol. 15 (8), pp. 2806-2825. Date of Electronic Publication: 2024 Jun 19 (Print Publication: 2024).
Autor:
Wijaya GYA; Doctoral School in Life Sciences, University of Siena, 53100 Siena, Italy.; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Cuffaro D; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy., Bertini S; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Digiacomo M; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy., Macchia M; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Center 'Nutraceuticals and Food for Health', University of Pisa, 56100 Pisa, Italy.
Publikováno v:
Nutrients [Nutrients] 2024 May 13; Vol. 16 (10). Date of Electronic Publication: 2024 May 13.