Abstract P4-06-04: Targeting neo-epitopes from PIK3CA and p53 mutations for immunotherapy of breast cancer

Autor: MA Wilson Sayres, Karen S. Anderson, P Yuvaraj, Pooja Narang, Meixuan Chen, AA Sharma

Publikováno v: Cancer Research. 79:P4-06

Introduction: Preclinical data suggests that priming T cell immunity to mutated or overexpressed proteins can induce tumor rejection, and may potentiate the effects of checkpoint blockade. PIK3CA and p53 are the most commonly mutated genes in breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1b98cf3e44573cfe42b4dfab38e0aea
https://doi.org/10.1158/1538-7445.sabcs18-p4-06-04

Author Correction: 137 ancient human genomes from across the Eurasian steppes.

Autor: de Barros Damgaard P; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Marchi N; Eco-anthropologie et Ethnobiologie, Muséum national d'Histoire naturelle, CNRS, Université Paris Diderot, Paris, France., Rasmussen S; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark., Peyrot M; Leiden University Centre for Linguistics, Leiden University, Leiden, The Netherlands., Renaud G; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Korneliussen T; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Department of Zoology, University of Cambridge, Cambridge, UK., Moreno-Mayar JV; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Pedersen MW; Department of Zoology, University of Cambridge, Cambridge, UK., Goldberg A; Department of Biology, Stanford University, Stanford, CA, USA., Usmanova E; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Baimukhanov N; Shejire DNA, Almaty, Kazakhstan., Loman V; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Hedeager L; Department of Archaeology, Conservation and History, University of Oslo, Oslo, Norway., Pedersen AG; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark., Nielsen K; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark.; Carlsberg Research Laboratory, Copenhagen, Denmark., Afanasiev G; Department of Theory and Methods, Institute of Archaeology Russian Academy of Sciences, Moscow, Russia., Akmatov K; Department of History, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan., Aldashev A; National Academy of Sciences of Kyrgyzstan, Bishkek, Kyrgyzstan., Alpaslan A; Department of History, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan., Baimbetov G; Shejire DNA, Almaty, Kazakhstan., Bazaliiskii VI; Department of History, Irkutsk State University, Irkutsk, Russia., Beisenov A; A. Kh. Margulan Institute of Archaeology, Almaty, Kazakhstan., Boldbaatar B; Laboratory of Virology, Institute of Veterinary Medicine, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia., Boldgiv B; Department of Biology, School of Arts and Sciences, National University of Mongolia, Ulaanbaatar, Mongolia., Dorzhu C; Departament of Biology and Ecology, Tuvan State University, Kyzyl, Russia., Ellingvag S; The Explico Foundation, Floro, Norway., Erdenebaatar D; Department of Archaeology, Ulaanbaatar State University, Ulaanbaatar, Mongolia., Dajani R; Department of Biology and Biotechnology, Hashemite University, Zarqa, Jordan.; Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA, USA., Dmitriev E; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Evdokimov V; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Frei KM; Unit for Environmental Archaeology and Materials Science, National Museum of Denmark, Copenhagen, Denmark., Gromov A; Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) RAS, St. Petersburg, Russia., Goryachev A; Archaeological Expertise LLC, Almaty, Kazakhstan., Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hegay T; Republican Scientific Center of Immunology, Ministry of Public Health, Tashkent, Uzbekistan., Khachatryan Z; Department of Bioengineering, Bioinformatics and Molecular Biology, Russian-Armenian University, Yerevan, Armenia., Khaskhanov R; Complex Research Institute of the Russian Academy of Sciences, Grozny, Russia., Kitov E; A. Kh. Margulan Institute of Archaeology, Almaty, Kazakhstan.; Institute of Ethnology and Anthropology, Russian Academy of Science, Moscow, Russia., Kolbina A; Kostanay Regional Local History Museum, Kostanay, Kazakhstan., Kubatbek T; Department of History, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan., Kukushkin A; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Kukushkin I; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Lau N; Centre for Baltic and Scandinavian Archaeology, Schleswig, Germany., Margaryan A; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Ethnogenomics, Institute of Molecular Biology, National Academy of Sciences of Armenia, Yerevan, Armenia., Merkyte I; Saxo-Institute, University of Copenhagen, Copenhagen, Denmark., Mertz IV; Center for Archaeological Research, S. Toraighyrov Pavlodar State University, Pavlodar, Kazakhstan., Mertz VK; Center for Archaeological Research, S. Toraighyrov Pavlodar State University, Pavlodar, Kazakhstan., Mijiddorj E; Department of Archaeology, Ulaanbaatar State University, Ulaanbaatar, Mongolia., Moiyesev V; Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) RAS, St. Petersburg, Russia., Mukhtarova G; The State Historical and Cultural Reserve-Museum (ISSYK), Almaty, Kazakhstan., Nurmukhanbetov B; The State Historical and Cultural Reserve-Museum (ISSYK), Almaty, Kazakhstan., Orozbekova Z; Institute of Archeology and Ethnography of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Panyushkina I; University of Arizona, Laboratory of Tree-Ring Research, Tucson, AZ, USA., Pieta K; Institute of Archaeology of the Slovak Academy of Sciences, Nitra, Slovakia., Smrčka V; Institute for History of Medicine and Foreign Languages, First Faculty of Medicine, Charles University, Prague, Czech Republic., Shevnina I; Archaeological Laboratory, Kostanay State University, Kostanay, Kazakhstan., Logvin A; Archaeological Laboratory, Kostanay State University, Kostanay, Kazakhstan., Sjogren KG; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Štolcova T; Institute of Archaeology of the Slovak Academy of Sciences, Nitra, Slovakia., Taravella AM; School of Life Sciences, Center for Evolution and Medicine, The Biodesign Institute, Arizona State University, Tempe, AZ, USA., Tashbaeva K; Institute of History and Cultural Heritage of National Academy of Sciences, Bishkek, Kyrgyzstan., Tkachev A; Institute of Problems Development of the North Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia., Tulegenov T; The State Historical and Cultural Reserve-Museum (ISSYK), Almaty, Kazakhstan., Voyakin D; Archaeological Expertise LLC, Almaty, Kazakhstan., Yepiskoposyan L; Department of Bioengineering, Bioinformatics and Molecular Biology, Russian-Armenian University, Yerevan, Armenia., Undrakhbold S; Department of Biology, School of Arts and Sciences, National University of Mongolia, Ulaanbaatar, Mongolia., Varfolomeev V; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Weber A; Department of Anthropology, University of Alberta, Edmonton, Alberta, Canada., Wilson Sayres MA; School of Life Sciences, Center for Evolution and Medicine, The Biodesign Institute, Arizona State University, Tempe, AZ, USA., Kradin N; Institute of History, Archaeology and Ethnology, Far-Eastern Branch of the Russian Academy of Sciences, Ulan-Ude, Russia.; Institute of Mongolian, Buddhist, and Tibetan Studies, Siberian Branch of the Russian Academy of Sciences, Ulan-Ude, Russia., Allentoft ME; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Orlando L; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Laboratoire d'Anthropobiologie Moléculaire et d'Imagerie de Synthèse, Université de Toulouse, Université Paul Sabatier, Toulouse, France., Nielsen R; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Departments of Integrative Biology and Statistics, University of Berkeley, Berkeley, CA, USA., Sikora M; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Heyer E; Eco-anthropologie et Ethnobiologie, Muséum national d'Histoire naturelle, CNRS, Université Paris Diderot, Paris, France., Kristiansen K; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Willerslev E; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark. ewillerslev@snm.ku.dk.; Department of Zoology, University of Cambridge, Cambridge, UK. ewillerslev@snm.ku.dk.; Wellcome Trust Sanger Institute, Hinxton, UK. ewillerslev@snm.ku.dk.

Publikováno v: Nature [Nature] 2018 Nov; Vol. 563 (7729), pp. E16.

The synthetic histone-binding regulator protein PcTF activates interferon genes in breast cancer cells.

Autor: Olney KC; School of Life Sciences, Arizona State University, 427 E Tyler Mall, Tempe, 85287-4501, AZ, USA., Nyer DB; School of Biological and Health Systems Engineering, Arizona State University, 501 E Tyler Mall, Tempe, AZ, 85287-9709, USA., Vargas DA; School of Biological and Health Systems Engineering, Arizona State University, 501 E Tyler Mall, Tempe, AZ, 85287-9709, USA., Wilson Sayres MA; School of Life Sciences, Arizona State University, 427 E Tyler Mall, Tempe, 85287-4501, AZ, USA.; Center for Evolution and Medicine, Arizona State University, 427 E Tyler Mall, Tempe, 85287-1701, AZ, USA., Haynes KA; School of Biological and Health Systems Engineering, Arizona State University, 501 E Tyler Mall, Tempe, AZ, 85287-9709, USA. karmella.haynes@asu.edu.

Publikováno v: BMC systems biology [BMC Syst Biol] 2018 Sep 25; Vol. 12 (1), pp. 83. Date of Electronic Publication: 2018 Sep 25.

The association of genomic lesions and PD-1/PD-L1 expression in resected triple-negative breast cancers.

Autor: Barrett MT; Division of Hematology and Medical Oncology, Mayo Clinic in Arizona, Scottsdale, AZ, USA. barrett.michael@mayo.edu., Lenkiewicz E; Division of Hematology and Medical Oncology, Mayo Clinic in Arizona, Scottsdale, AZ, USA., Malasi S; Division of Hematology and Medical Oncology, Mayo Clinic in Arizona, Scottsdale, AZ, USA., Basu A; Division of Hematology and Medical Oncology, Mayo Clinic in Arizona, Scottsdale, AZ, USA., Yearley JH; Merck Research Laboratories, Palo Alto, CA, USA., Annamalai L; Merck Research Laboratories, Palo Alto, CA, USA., McCullough AE; Department of Pathology and Laboratory Medicine, Mayo Clinic in Arizona, Scottsdale, AZ, USA., Kosiorek HE; Division of Hematology and Medical Oncology, Mayo Clinic in Arizona, Scottsdale, AZ, USA., Narang P; School of Life Sciences, Arizona State University, Tempe, AZ, USA., Wilson Sayres MA; School of Life Sciences, Arizona State University, Tempe, AZ, USA., Chen M; Biodesign Institute, Arizona State University, Tempe, AZ, USA., Anderson KS; Biodesign Institute, Arizona State University, Tempe, AZ, USA.; Division of Hematology and Medical Oncology, Mayo Clinic in Arizona, Phoenix, AZ, USA., Pockaj BA; Division of General Surgery, Section of Surgical Oncology, Mayo Clinic in Arizona, Phoenix, AZ, USA.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2018 Jul 11; Vol. 20 (1), pp. 71. Date of Electronic Publication: 2018 Jul 11.

137 ancient human genomes from across the Eurasian steppes.

Autor: Damgaard PB; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Marchi N; Eco-anthropologie et Ethnobiologie, Muséum national d'Histoire naturelle, CNRS, Université Paris Diderot, Paris, France., Rasmussen S; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark., Peyrot M; Leiden University Centre for Linguistics, Leiden University, Leiden, The Netherlands., Renaud G; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Korneliussen T; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Department of Zoology, University of Cambridge, Cambridge, UK., Moreno-Mayar JV; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Pedersen MW; Department of Zoology, University of Cambridge, Cambridge, UK., Goldberg A; Department of Biology, Stanford University, Stanford, CA, USA., Usmanova E; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Baimukhanov N; Shejire DNA, Almaty, Kazakhstan., Loman V; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Hedeager L; Department of Archaeology, Conservation and History, University of Oslo, Oslo, Norway., Pedersen AG; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark., Nielsen K; Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark.; Carlsberg Research Laboratory, Copenhagen, Denmark., Afanasiev G; Department of Theory and Methods, Institute of Archaeology Russian Academy of Sciences, Moscow, Russia., Akmatov K; Department of History, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan., Aldashev A; National Academy of Sciences of Kyrgyzstan, Bishkek, Kyrgyzstan., Alpaslan A; Department of History, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan., Baimbetov G; Shejire DNA, Almaty, Kazakhstan., Bazaliiskii VI; Department of History, Irkutsk State University, Irkutsk, Russia., Beisenov A; A. Kh. Margulan Institute of Archaeology, Almaty, Kazakhstan., Boldbaatar B; Laboratory of Virology, Institute of Veterinary Medicine, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia., Boldgiv B; Department of Biology, School of Arts and Sciences, National University of Mongolia, Ulaanbaatar, Mongolia., Dorzhu C; Departament of Biology and Ecology, Tuvan State University, Kyzyl, Russia., Ellingvag S; The Explico Foundation, Floro, Norway., Erdenebaatar D; Department of Archaeology, Ulaanbaatar State University, Ulaanbaatar, Mongolia., Dajani R; Department of Biology and Biotechnology, Hashemite University, Zarqa, Jordan.; Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA, USA., Dmitriev E; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Evdokimov V; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Frei KM; Unit for Environmental Archaeology and Materials Science, National Museum of Denmark, Copenhagen, Denmark., Gromov A; Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) RAS, St. Petersburg, Russia., Goryachev A; Archaeological Expertise LLC, Almaty, Kazakhstan., Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hegay T; Republican Scientific Center of Immunology, Ministry of Public Health, Tashkent, Uzbekistan., Khachatryan Z; Department of Bioengineering, Bioinformatics and Molecular Biology, Russian-Armenian University, Yerevan, Armenia., Khaskhanov R; Complex Research Institute of the Russian Academy of Sciences, Grozny, Russia., Kitov E; A. Kh. Margulan Institute of Archaeology, Almaty, Kazakhstan.; Institute of Ethnology and Anthropology, Russian Academy of Science, Moscow, Russia., Kolbina A; Kostanay Regional Local History Museum, Kostanay, Kazakhstan., Kubatbek T; Department of History, Kyrgyzstan-Turkey Manas University, Bishkek, Kyrgyzstan., Kukushkin A; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Kukushkin I; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Lau N; Centre for Baltic and Scandinavian Archaeology, Schleswig, Germany., Margaryan A; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Laboratory of Ethnogenomics, Institute of Molecular Biology, National Academy of Sciences of Armenia, Yerevan, Armenia., Merkyte I; Saxo-Institute, University of Copenhagen, Copenhagen, Denmark., Mertz IV; Center for Archaeological Research, S. Toraighyrov Pavlodar State University, Pavlodar, Kazakhstan., Mertz VK; Center for Archaeological Research, S. Toraighyrov Pavlodar State University, Pavlodar, Kazakhstan., Mijiddorj E; Department of Archaeology, Ulaanbaatar State University, Ulaanbaatar, Mongolia., Moiyesev V; Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) RAS, St. Petersburg, Russia., Mukhtarova G; The State Historical and Cultural Reserve-Museum (ISSYK), Almaty, Kazakhstan., Nurmukhanbetov B; The State Historical and Cultural Reserve-Museum (ISSYK), Almaty, Kazakhstan., Orozbekova Z; Institute of Archeology and Ethnography of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Panyushkina I; University of Arizona, Laboratory of Tree-Ring Research, Tucson, AZ, USA., Pieta K; Institute of Archaeology of the Slovak Academy of Sciences, Nitra, Slovakia., Smrčka V; Institute for History of Medicine and Foreign Languages, First Faculty of Medicine, Charles University, Prague, Czech Republic., Shevnina I; Archaeological Laboratory, Kostanay State University, Kostanay, Kazakhstan., Logvin A; Archaeological Laboratory, Kostanay State University, Kostanay, Kazakhstan., Sjögren KG; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Štolcová T; Institute of Archaeology of the Slovak Academy of Sciences, Nitra, Slovakia., Taravella AM; School of Life Sciences, Center for Evolution and Medicine, The Biodesign Institute, Arizona State University, Tempe, AZ, USA., Tashbaeva K; Institute of History and Cultural Heritage of National Academy of Sciences, Bishkek, Kyrgyzstan., Tkachev A; Institute of Problems Development of the North Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia., Tulegenov T; The State Historical and Cultural Reserve-Museum (ISSYK), Almaty, Kazakhstan., Voyakin D; Archaeological Expertise LLC, Almaty, Kazakhstan., Yepiskoposyan L; Department of Bioengineering, Bioinformatics and Molecular Biology, Russian-Armenian University, Yerevan, Armenia., Undrakhbold S; Department of Biology, School of Arts and Sciences, National University of Mongolia, Ulaanbaatar, Mongolia., Varfolomeev V; Buketov Karaganda State University, Saryarka Archaeological Institute, Karaganda, Kazakhstan., Weber A; Department of Anthropology, University of Alberta, Edmonton, Alberta, Canada., Wilson Sayres MA; School of Life Sciences, Center for Evolution and Medicine, The Biodesign Institute, Arizona State University, Tempe, AZ, USA., Kradin N; Institute of History, Archaeology and Ethnology, Far-Eastern Branch of the Russian Academy of Sciences, Ulan-Ude, Russia.; Institute of Mongolian, Buddhist, and Tibetan Studies, Siberian Branch of the Russian Academy of Sciences, Ulan-Ude, Russia., Allentoft ME; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Orlando L; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Laboratoire d'Anthropobiologie Moléculaire et d'Imagerie de Synthèse, Université de Toulouse, Université Paul Sabatier, Toulouse, France., Nielsen R; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.; Departments of Integrative Biology and Statistics, University of Berkeley, Berkeley, CA, USA., Sikora M; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark., Heyer E; Eco-anthropologie et Ethnobiologie, Muséum national d'Histoire naturelle, CNRS, Université Paris Diderot, Paris, France., Kristiansen K; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Willerslev E; Center for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark. ewillerslev@snm.ku.dk.; Department of Zoology, University of Cambridge, Cambridge, UK. ewillerslev@snm.ku.dk.; Wellcome Trust Sanger Institute, Hinxton, UK. ewillerslev@snm.ku.dk.

Publikováno v: Nature [Nature] 2018 May; Vol. 557 (7705), pp. 369-374. Date of Electronic Publication: 2018 May 09.