Zobrazeno 1 - 10
of 244
pro vyhledávání: '"MA Packham"'
Publikováno v:
Blood. 75(5)
Normal human platelets aggregated by thrombin undergo the release reaction and are not readily deaggregated by the combination of inhibitors hirudin, chymotrypsin, and prostaglandin E1 (PGE1). In contrast, thrombin-induced aggregates of platelets fro
Publikováno v:
Blood. 70:221-226
Platelets from two afibrinogenemic patients were used to determine whether fibrinogen is essential for platelet aggregation and to examine whether released fibrinogen contributes to the stabilization of platelet aggregates when platelets have been in
Autor:
MA Packham, JF Mustard
Publikováno v:
Blood. 50:555-573
Publikováno v:
Blood. 71:850-860
The association of fibrinogen with washed human platelets was examined by immunocytochemistry during aggregation induced by adenosine diphosphate (ADP) and during deaggregation. The platelets were suspended either in a medium containing 2 mmol/L Ca2+
Publikováno v:
Blood. 71:1310-1320
Because thrombin aggregates afibrinogenemic platelets and platelets from patients with the gray platelet syndrome and because antibodies to fibrinogen inhibit thrombin-induced aggregation only at low concentrations of thrombin, the role of fibrinogen
Publikováno v:
Blood. 54(5)
Although 125I-fibrinogen becomes associated with washed platelets from normal human subjects during ADP-induced shape change and aggregation, 125I-fibrinogen did not become associated with washed plateletes from a thrombasthenic subject during ADP-in
Publikováno v:
Blood. 59(5)
The method for preparing thrombin-degranulated platelets has been modified to avoid the use of plasmin or successive treatments with small amounts of thrombin, while still achieving more than 90% release of platelet amine storage granule contents. It
Publikováno v:
Blood. 57(4)
Publikováno v:
Blood. 70(3)
Close platelet-to-platelet contact induced by weak agonists in a medium with a low concentration of Ca2+ leads to thromboxane A2 (TXA2) formation, release of granule contents, and secondary aggregation. These responses do not occur in a medium contai
Publikováno v:
Blood. 53(5)