Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

Autor: Paul Jank, Dorraya El-Ashry, Qiang Zhang, Benjamin Troness, Adrian V. Lee, Lakjaya Buluwela, Callen T. Wallace, Jennifer M. Atkinson, Yao-Wen Wu, J-U Blohmer, Steffi Oesterreich, Megan E. Yates, George C. Tseng, Lorenzo Gerratana, Jingxin Chen, Nikhil Wagle, Jason S. Carroll, Simon C. Watkins, Prithu Sundd, Kevin M. Levine, Amir Bahreini, Jennifer K. Richer, Massimo Cristofanilli, Y Zhang, Nilgun Tasdemir, Spencer Arnesen, Peter C. Lucas, Jason Gertz, Simak Ali, MM Karsten, Li Zhu, MA Montanez, Ben Ho Park, Carsten Denkert, Nolan Priedigkeit, Zheqi Li

Constitutively active estrogen receptor-α (ER/ESR1) mutations have been identified in approximately one third of ER+ metastatic breast cancer. Although these mutations are known mediators of endocrine resistance, their potential role in promoting me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9decdc3eda9520e341177a9489c421bb
https://doi.org/10.1101/2021.02.10.430701

Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis.

Autor: Li Z; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Wu Y; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; School of Medicine, Tsinghua University, Beijing, P.R. China., Yates ME; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Integrative Systems Biology Program, University of Pittsburgh, Pittsburgh, Pennsylvania.; Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Tasdemir N; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Bahreini A; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania., Chen J; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Levine KM; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania., Priedigkeit NM; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Nasrazadani A; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Ali S; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Buluwela L; Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Arnesen S; Department of Oncological Sciences, University of Utah, Salt Lake City, Utah.; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Gertz J; Department of Oncological Sciences, University of Utah, Salt Lake City, Utah.; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah., Richer JK; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Troness B; University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota., El-Ashry D; University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota., Zhang Q; Robert H. Lurie Cancer Center of Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Gerratana L; Robert H. Lurie Cancer Center of Northwestern University, Feinberg School of Medicine, Chicago, Illinois.; Department of Medicine (DAME) University of Udine, Udine, Italy., Zhang Y; Robert H. Lurie Cancer Center of Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Cristofanilli M; Robert H. Lurie Cancer Center of Northwestern University, Feinberg School of Medicine, Chicago, Illinois., Montanez MA; Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Sundd P; Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Wallace CT; Center for Biological Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania., Watkins SC; Center for Biological Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania., Fumagalli C; Division of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy., Guerini-Rocco E; Division of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Zhu L; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania., Tseng GC; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania., Wagle N; Department of Medical Oncology and Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts., Carroll JS; Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Jank P; Institut of Pathology, Philipps-University Marburg, UKGM - Universitätsklinikum Marburg, Marburg, Germany., Denkert C; Institut of Pathology, Philipps-University Marburg, UKGM - Universitätsklinikum Marburg, Marburg, Germany., Karsten MM; Department of Gynecology with Breast Center, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humbold-Univeristät zu Berlin and Berlin Institute of Health, Berlin, Germany., Blohmer JU; Department of Gynecology with Breast Center, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humbold-Univeristät zu Berlin and Berlin Institute of Health, Berlin, Germany., Park BH; Vanderbilt University Ingraham Cancer Center, Nashville, Tennessee., Lucas PC; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania., Atkinson JM; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania., Lee AV; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Integrative Systems Biology Program, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania., Oesterreich S; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Women's Cancer Research Center, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Integrative Systems Biology Program, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Publikováno v: Cancer research [Cancer Res] 2022 Apr 01; Vol. 82 (7), pp. 1321-1339.