Zobrazeno 1 - 10
of 49
pro vyhledávání: '"MA Guccione"'
Publikováno v:
Thrombosis and Haemostasis. 70:1019-1023
SummaryA new, simplified method of degranulating human platelets using the thrombin receptor peptide SFLLRN (20 |iM) is described; released fibrinogen cannot be converted to fibrin, and the platelets are not exposed to a proteolytic enzyme, as they a
Publikováno v:
Blood. 59:956-962
It has been established that fibrinogen binding occurs during adenosine diphosphate (ADP)-induced platelet aggregation, but studies of fibrinogen binding to platelets stimulated with arachidonate or most other aggregating agents are complicated by th
Autor:
JP Greenberg, MA Guccione, Margaret L. Rand, Hans-Joachim Reimers, JF Mustard, Marian A. Packham
Publikováno v:
Blood. 53:916-927
Platelets from which surface sialic acid has been removed by neuraminidase are rapidly cleared from the circulation. In the present study the role of platelet membrane glycoproteins in platelet survival was further investigated with 51Cr-labeled rabb
Publikováno v:
Blood. 50:915-926
Release of 14C-serotonin from prelabeled platelets during the lag phase before aggregation and during aggregation caused by low concentrations of thrombin, collagen, or A23187 was measured after stopping release instantaneously with paraformaldehyde.
Publikováno v:
American Journal of Physiology-Legacy Content. 227:1143-1148
Publikováno v:
Thrombosis and Haemostasis. 36:360-375
SummaryThe effects of polylysine on human platelets have been examined in citrated platelet-rich plasma (PRP) and in suspensions of washed platelets in various media. In PRP, polylysine caused aggregation after a lag phase. Heparin inhibited this com
Publikováno v:
Blood. 66:287-290
The controversy concerning the relationship between platelet buoyant density and platelet age is unresolved. Our earlier results with rabbit platelets indicate that the most-dense subpopulations are enriched in young platelets and that some platelets
Publikováno v:
Blood. 56:876-880
Some investigators have reported recently that platelet surface sialic acid is decreased during ADP-induced aggregation, whereas others have reported an increase. Since removal of sialic acid from the platelet surface shortens platelet survival, we h
Publikováno v:
Blood. 37:542-555
Using suspensions of washed rabbit platelets that react to low concentrations of ADP in the same way as platelets in plasma, it has been found that the major change in added 14C-ADP is its conversion to 14C-ATP, catalyzed by nucleoside diphosphokinas
Publikováno v:
Blood. 59(5)
The method for preparing thrombin-degranulated platelets has been modified to avoid the use of plasmin or successive treatments with small amounts of thrombin, while still achieving more than 90% release of platelet amine storage granule contents. It