Zobrazeno 1 - 10
of 594
pro vyhledávání: '"M2 proton channel"'
Autor:
Timur Mansurovich Garaev, Artyom Irorevich Odnovorov, Alexander Aleksandrovich Lashkov, Tatiana Vladimirovna Grebennikova, Marina Pavlovna Finogenova, Galina Kadymovna Sadykova, Alexei Gennadievich Prilipov, Tatiana Anatol'evna Timofeeva, Sergey Vadimovich Rubinsky, Svetlana Nikolaevna Norkina, Marina Mikhailovna Zhuravleva
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 11, Iss 4, Pp 700-711 (2021)
Purpose: The aminoadamantane derivative of L-histidyl-1-adamantayl ethylamine hydrochloride (HCl*H-His-Rim) has showed a high inhibition level against influenza A virus strains in vitro. The aim of this work is to search and establish evidence of the
Externí odkaz:
https://doaj.org/article/707f16e09811496d8d64eec50aea33f8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel a
Externí odkaz:
https://doaj.org/article/ef28bac443034879869ad31a6ba782ef
Akademický článek
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Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity
Autor:
Athina Konstantinidi, William F. DeGrado, Jessica L. Thomaston, Yanmei Hu, Hannah E. Bruce Macdonald, Marley L. Samways, Chunlong Ma, Jonathan W. Essex, Antonios Kolocouris, Jun Wang
Publikováno v:
Biochemistry
The influenza A M2 wild-type (WT) proton channel is the target of the anti-influenza drug rimantadine. Rimantadine has two enantiomers, though most investigations into drug binding and inhibition have used a racemic mixture. Solid-state NMR experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97622ab623be9c3a5c693688521b7904
https://pubmed.ncbi.nlm.nih.gov/34342217
https://pubmed.ncbi.nlm.nih.gov/34342217
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Marina Pavlovna Finogenova, Tatiana Vladimirovna Grebennikova, Tatiana Anatol'evna Timofeeva, Alexander Aleksandrovich Lashkov, Galina K. Sadykova, Artyom Irorevich Odnovorov, Marina Mikhailovna Zhuravleva, Sergey Vadimovich Rubinsky, Svetlana Nikolaevna Norkina, T. M. Garaev, Alexei Gennadievich Prilipov
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 11, Iss 4, Pp 700-711 (2021)
Purpose: The aminoadamantane derivative of L-histidyl-1-adamantayl ethylamine hydrochloride (HCl*H-His-Rim) has showed a high inhibition level against influenza A virus strains in vitro. The aim of this work is to search and establish evidence of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d5b21c1e5d2264967b65cbc9e2a801
https://doi.org/10.34172/apb.2021.079
https://doi.org/10.34172/apb.2021.079
Autor:
Yue Zhang, Qing-Chuan Zheng
Publikováno v:
The Journal of Physical Chemistry Letters. 12:1169-1174
The M2 proton channel of influenza A (AM2) and B (BM2) have a highly conserved function motif, considered as the effective target. As yet, there is no effective drug against BM2. Research showed that AM2 channel blocker, amantadine (AMT), was able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3698e46e5a3bb2686125014a037be6
https://doi.org/10.1021/acs.jpclett.0c03560
https://doi.org/10.1021/acs.jpclett.0c03560
Mechanism and Kinetics of Copper Complexes Binding to the Influenza A M2 S31N and S31N/G34E Channels
Autor:
Daniel H. Ess, Jonathan T. Hill, David D. Busath, Roger G. Harrison, Phillip Smit, Kelly L. McGuire
Publikováno v:
Biophys J
Copper(II) is known to bind in the influenza virus His37 cluster in the homotetrameric M2 proton channel and block the proton current needed for uncoating. Copper complexes based on iminodiacetate also block the M2 proton channel and show reduced cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83494a3b4447ed7137ab6de0bbb1a1bd
https://doi.org/10.1016/j.bpj.2020.11.016
https://doi.org/10.1016/j.bpj.2020.11.016
Akademický článek
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Autor:
Elka R. Georgieva, Peter P. Borbat, Kirill Grushin, Svetla Stoilova-McPhie, Nichita J. Kulkarni, Zhichun Liang, Jack H. Freed
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
The M2 protein from influenza A plays important roles in its viral cycle. It contains a single transmembrane helix, which oligomerizes into a homotetrameric proton channel that conducts in the low-pH environment of the host-cell endosome and Golgi ap
Externí odkaz:
https://doaj.org/article/342ed16b938a4175b60805e963dbb617