Zobrazeno 1 - 10
of 319
pro vyhledávání: '"M1 receptor"'
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Cognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with s
Externí odkaz:
https://doaj.org/article/98c84786a3e24a8ea9a6f3a1a70a40c1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2024)
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins. Accumulating evidence
Externí odkaz:
https://doaj.org/article/fcd8ec3982c746f8a704e59d36f70fea
Autor:
Göksel Şener, Gözde Karakadıoglu, Dilek Ozbeyli, Seren Ede, Refiye Yanardag, Ozlem Sacan, Asli Aykac
Publikováno v:
Food Science and Human Wellness, Vol 11, Iss 5, Pp 1290-1298 (2022)
This study was designed to investigate whether Petroselinum crispum (PC) extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease (AD) rat model. The rats were divided into; control, scopolamine (1 mg/kg, i.p.), ga
Externí odkaz:
https://doaj.org/article/df28a4f2c12842c6a10952de175b7830
Autor:
Brian Dean, Geor Bakker, Hiroki R. Ueda, Andrew B. Tobin, Alastair Brown, Richard A. A. Kanaan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of schizophrenia. From these data it was proposed that activation of the muscarinic M1 and/or M4 receptor would reduce the
Externí odkaz:
https://doaj.org/article/17f6b5e38bfb42699304842dee624e12
The pathophysiology of rapid fluctuations in mental status associated with olanzapine: A case report
Autor:
Tyler J. Torrico
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
BackgroundOlanzapine toxicity is reported to be a rare but specific phenomenon characterized by rapid fluctuations between somnolence and agitation, which has been referred to as “agitation despite sedation.” A similar phenomenon is observed as a
Externí odkaz:
https://doaj.org/article/c1eb85185f394525a283f8f83e846b9e
Publikováno v:
Di-san junyi daxue xuebao, Vol 43, Iss 18, Pp 1796-1805 (2021)
Objective To determine the effect of muscarinic acetylcholine M1 receptor (CHRM1) on pyroptosis of prostate cancer cells and investigate its possible molecular mechanism. Methods Pirenzepine (PIN), a specific CHRM1 antagonist, and bethanechol (BETH),
Externí odkaz:
https://doaj.org/article/0d14422b745b44d1a583cfec16420140
Autor:
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Robert Jan Doll, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic treatment of Demen
Externí odkaz:
https://doaj.org/article/8f25b2ca13ee46c9988b118de2ad5f58
Autor:
Wu Q, Cao Y, Liu M, Liu F, Brantner AH, Yang Y, Wei Y, Zhou Y, Wang Z, Ma L, Wang F, Pei H, Li H
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3167-3176 (2019)
Qiong Wu,1,2,* Yu Cao,1,* Meixia Liu,1 Fang Liu,1 Adelheid H Brantner,3 Yang Yang,1 Yun Wei,1 Yu Zhou,4 Zhiyong Wang,1 Lina Ma,1 Feixue Wang,1 Hui Pei,1 Hao Li1 1Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Be
Externí odkaz:
https://doaj.org/article/923397c1f4524f8bbd51f4a0e39cb570
Autor:
Susheel Vijayraghavan, Stefan Everling
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been s
Externí odkaz:
https://doaj.org/article/fb4493ea14984b5d93e7f024c823c435
Autor:
Veronica C. Galvin, Shengtao Yang, Adam S. Lowet, Dibyadeep Datta, Alvaro Duque, Amy FT. Arnsten, Min Wang
Publikováno v:
Current Research in Neurobiology, Vol 2, Iss , Pp 100016- (2021)
The recurrent excitatory circuits in dlPFC underlying working memory are known to require activation of glutamatergic NMDA receptors (NMDAR). The neurons in these circuits also rely on acetylcholine to maintain persistent activity, with evidence for
Externí odkaz:
https://doaj.org/article/f4ca6c5755e54571a374c23ac57aee82