Zobrazeno 1 - 10
of 138
pro vyhledávání: '"M.W. Lark"'
Autor:
Dennis S. Yamashita, Thaddeus A. Tomaszek, H.-J. Oh, M.W. Lark, S M Hwang, David J. Rickard, Ian E. James, Jae U. Jeong, Robert W. Marquis, George B. Stroup, M. Gowen, Shaji Kumar, Lauren Dare, Simon M. Blake, Daniel F. Veber, Janice A. Vasko-Moser
Publikováno v:
Bone. 40:122-131
Cathepsin K is an osteoclast-derived cysteine protease that has been implicated as playing a major role in bone resorption. A substantial body of evidence indicates that cathepsin K is critical in osteoclast-mediated bone resorption and suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e6d676f9661e2618786dd5a638714d
https://doi.org/10.1016/j.bone.2006.07.015
https://doi.org/10.1016/j.bone.2006.07.015
Publikováno v:
Osteoarthritis and Cartilage; 14(2), pp 101-113 (2006)
Objective: To identify the major aggrecanase-and matrix metalloproteinase (MMP)-generated aggrecan fragments in human osteoarthritis (OA) synovial fluid and in human OA joint cartilage. Method Aggrecan fragments were prepared by CsCl gradient centrif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eee05eda87a038a5e54a599a0f9db3c
https://doi.org/10.1016/j.joca.2005.07.018
https://doi.org/10.1016/j.joca.2005.07.018
Autor:
Ian E. James, Simon M. Blake, E. Berger, M.W. Lark, Alan J. Grodzinsky, Parth Patwari, Véronique Gaschen, Ernst B. Hunziker
Publikováno v:
Osteoarthritis and Cartilage. 12:245-252
Objective: It has been suggested that chondrocyte death by apoptosis may play a role in the pathogenesis of cartilage destruction in osteoarthritis, but the results of in-vivo and in-vitro investigations have been conflicting. To investigate further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5610c20a828af4323c05d44db2efd7b2
https://doi.org/10.1016/j.joca.2003.11.004
https://doi.org/10.1016/j.joca.2003.11.004
Autor:
Kevin L. Salyers, James Samanen, R. Curtis Haltiwanger, M.W. Lark, Leonard M. Azzarano, Irene N. Uzinskas, Karl F. Erhard, Robert N. Willette, Kyung O. Johanson, Catherine J. Gress, Stephen T Ross, Tian Li Yue, Keith W. Ward, William F. Huffman, Russell D. Cousins, Dirk A. Heerding, David J. Rieman, Shing Mei Hwang, Chet Kwon, Brian R. Smith, Ian E. James, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata, Manley Peter J
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1483-1486
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b020a8d8d76827308cf4beb670e93f46
https://doi.org/10.1016/s0960-894x(03)00102-1
https://doi.org/10.1016/s0960-894x(03)00102-1
Autor:
M.W. Lark, Karen E. Morrison
Publikováno v:
Current Opinion in Pharmacology. 2:287-290
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59996d1acaf4dd68e5179b590501cbfe
https://doi.org/10.1016/s1471-4892(02)00167-4
https://doi.org/10.1016/s1471-4892(02)00167-4
Autor:
J.R. Connor, S.P. O'Brien, M.W. Lark, Ganesh M. Sathe, Shaji Kumar, P. Mui, J. Mooney, M. Gowen, P.R. Murdock
Publikováno v:
Osteoarthritis and Cartilage. 9:727-737
Objective To characterize the expression pattern of clusterin in adult human normal and osteoarthritic cartilage. Methods Clusterin mRNA expression in adult human normal and osteoarthritic cartilage was investigated by analysis of cDNA libraries, Taq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad5aff338f3b338bba7a9d8207300b6
https://doi.org/10.1053/joca.2001.0475
https://doi.org/10.1053/joca.2001.0475
Autor:
M.W. Lark, John C. Lee, P. Agarwal, Alison M. Badger, M. Van Horn, Ganesh M. Sathe, M. Gowen, P. Mui, Joyce Mao, J.R. Connor, Wendy S. Halsey, Shaji Kumar, R.A. Dodds
Publikováno v:
Osteoarthritis and Cartilage. 9(7):641-653
Objective To prepare, sequence and analyse adult human cartilage cDNA libraries to study the gene expression pattern between normal and osteoarthritic cartilage. Methods Poly A + RNA from adult human normal and osteoarthritic articular cartilage was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030daa0b1c89298c957862dca1821f5c
Autor:
J.R. Connor, M.W. Lark, Shaji Kumar, Alison M. Badger, Barbara A. Swift, A.K Roshak, M.N Cook, M. Gowen, K Carlson, T.M Newman-Tarr, John C. Lee
Publikováno v:
Osteoarthritis and Cartilage. 8(6):434-443
The p38 MAP kinase inhibitor, SB 242235, was evaluated for its effects on the metabolism of bovine and human cartilage and primary chondrocyte cultures. SB 242235 had no effect on proteoglycan synthesis (PG) in bovine articular cartilage explants (BA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20059bd67d179229afad3f97b64a714
Autor:
Barbara A. Swift, J.M Levin, M.W. Lark, Alison M. Badger, R.D Kapadia, R.W Coatney, A Bhattacharyya, R.A. Dodds
Publikováno v:
Osteoarthritis and Cartilage. 8(5):374-377
Objective The purpose of this study was to evaluate the ossification state of the meniscus in the guinea-pig stifle joint using micro-computerized tomography. Design Hind limbs from six ( N =12) and 24 ( N =11) month-old male Hartley guinea-pigs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f341f942a411af0cf278c94228e2e3
Autor:
Ian E. James, M.W. Lark, F.-L. Wang, J.R. Connor, Shaji Kumar, M.E. Nuttall, C. Zou, M. Gowen, R.A. Dodds
Publikováno v:
Osteoarthritis and Cartilage. 8:161-169
Objective The purpose of this study was to identify genes that are differentially expressed in normal versus osteoarthritic human articular cartilage as either potential novel therapeutic targets or diagnostic markers of this disease. Design mRNA was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5999b73ebbab1b61ac4fb7219ee238b
https://doi.org/10.1053/joca.1999.0295
https://doi.org/10.1053/joca.1999.0295