Zobrazeno 1 - 10
of 57
pro vyhledávání: '"M.V.P.S. Vishnuvardhan"'
Autor:
Ahmed Kamal, Ibrahim Bin Sayeed, Apoorva Nagarajan, M.V.P.S. Vishnuvardhan, Srinivas Kantevari
Publikováno v:
Bioorganic Chemistry. 80:714-720
A library of new imidazopyridine linked triazole hybrid conjugates (8a-r) were designed, synthesized and evaluated for their cytotoxicity against four cancer cell lines namely, human lung (A549), human prostate (DU-145), human colon (HCT-116) and bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e92d1b16c16c6bf44d4c8ccf3ff78e
https://doi.org/10.1016/j.bioorg.2018.07.026
https://doi.org/10.1016/j.bioorg.2018.07.026
Autor:
A. V. Subba Rao, Faria Sultana, Jeevak Sopanrao Kapure, Nishant Jain, M.V.P.S. Vishnuvardhan, Ahmed Kamal, Chandrakant Bagul, Siddiq Pasha Shaik, Debanjan Bhattacharjee
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3285-3297
1,2,3-Triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates (5a-v) were designed, synthesized and evaluated for their cytotoxic potency against some human cancer cell lines like DU-145 (prostate), HeLa (cervical), MCF-7 (breast) HepG2 (liver) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f710f280d79a3e274c2e858df7fa40
https://doi.org/10.1016/j.bmc.2017.04.013
https://doi.org/10.1016/j.bmc.2017.04.013
Autor:
Ahmed Kamal, V. Saidi Reddy, Abdullah Alarifi, V. Lakshma Nayak, Ibrahim Bin Sayeed, Kunta Chandrasekhar, M.V.P.S. Vishnuvardhan
Publikováno v:
MedChemComm. 8:1817-1823
A series of new triazolo linked 4β-amidopodophyllotoxin conjugates (9a-l) were synthesized using click chemistry and evaluated for their antitumor activity against four human cancer cell lines. Among them, two compounds (9c and 9j) showed significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aafc6c01a8292d90d2959e9048ae07b
https://doi.org/10.1039/c7md00273d
https://doi.org/10.1039/c7md00273d
Publikováno v:
Bioorganic Chemistry. 66:124-131
The PI3K/Akt/mTOR signaling pathway plays a key regulatory function in cell survival, proliferation, migration, metabolism and apoptosis. Aberrant activation of the PI3K/Akt/mTOR pathway is found in many types of cancer and thus plays a major role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d593c7c13a5b2f1cfec359130fa975
https://doi.org/10.1016/j.bioorg.2016.04.004
https://doi.org/10.1016/j.bioorg.2016.04.004
Autor:
Boppana Kiran, M.V.P.S. Vishnuvardhan, Shamshair Singh, S.M. Ali Hussaini, Balasubramanian Sridhar, Ahmed Kamal, Shaik Thokhir Basha, Md. Ashraf
Publikováno v:
Organic & Biomolecular Chemistry. 14:1382-1394
A new class of (E)-N-phenyl-3-styrylpyridin-2-amine conjugates were designed and synthesized on the basis of E7010 and resveratrol scaffolds. These conjugates were evaluated for their antiproliferative activity in four human cancer cell lines with GI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c012298bc89e55dee7ebe60764aaa25
https://doi.org/10.1039/c5ob02022k
https://doi.org/10.1039/c5ob02022k
Autor:
Nagula Shankaraiah, Narayana Nagesh, Vunnam Srinivasulu, K.P. Siraj, Kishna Ram Senwar, Pankaj Sharma, Chetna Jadala, M.V.P.S. Vishnuvardhan, Ahmed Kamal, Manda Sathish, Shalini Nekkanti, Sistla Ramakrishna
Publikováno v:
Bioorganic Chemistry. 59:130-139
A new series of DNA-interactive β-carboline-chalcone conjugates have been synthesized and evaluated for their in vitro cytotoxicity and DNA-binding affinity. It has been observed that most of these new hybrids have shown potent cytotoxic activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341be5c5e15b84c1cadbf97cde894aed
https://doi.org/10.1016/j.bioorg.2015.02.007
https://doi.org/10.1016/j.bioorg.2015.02.007
Autor:
Vangala Santhosh Reddy, Anver Basha Shaik, Nishant Jain, G. Bharath Kumar, M.V.P.S. Vishnuvardhan, Ahmed Kamal, Sowjanya Polepalli
Publikováno v:
Organic & Biomolecular Chemistry. 13:3416-3431
A new class of pyrazole and isoxazole conjugates were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines. These compounds have shown significant cytotoxicity with lower IC50 values. FACS results revealed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc29e492f1455b8efc416278f991e55a
https://doi.org/10.1039/c4ob02449d
https://doi.org/10.1039/c4ob02449d
Autor:
Nishant Jain, Chandrakant Bagul, Sowjanya Polepalli, A. Subba Rao, Siddiq Pasha Shaik, Ahmed Kamal, T. Srinivasa Reddy, M.V.P.S. Vishnuvardhan
Publikováno v:
MedChemComm. 6:1842-1856
Two series of 2-ethyl-6-(3′,4′,5′-trimethoxyphenyl)-5-aryl and 2-cyclopropyl-6-(3′,4′,5′-trimethoxyphenyl)-5-aryl-imidazothiadiazoles were designed, synthesized and evaluated for anti-proliferative activity in various human cancer cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11ad3efb72390f5dbeebc4607879a18
https://doi.org/10.1039/c5md00155b
https://doi.org/10.1039/c5md00155b
Autor:
Vunnam Srinivasulu, Konderu Swapna, Chandrakant Bagul, Ahmed Kamal, T. Srinivas Reddy, M.V.P.S. Vishnuvardhan, N. V. Subba Reddy, A. V. Subba Rao
Publikováno v:
Organic & Biomolecular Chemistry. 13:4879-4895
A series of 2-anilinopyridyl–triazole conjugates (6a–t) were prepared and evaluated for their cytotoxic activity against a panel of three human cancer cell lines. Among them compounds 6q, 6r and 6s showed significant cytotoxic activity with IC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582be2dba7f09ef5961988b78f8a9cbb
https://doi.org/10.1039/c5ob00232j
https://doi.org/10.1039/c5ob00232j
Synthesis of 2-anilinopyridine–arylpropenone conjugates as tubulin inhibitors and apoptotic inducers
Autor:
Ibrahim Bin Sayeed, M.V.P.S. Vishnuvardhan, Anver Basha Shaik, Praveen Reddy Adiyala, Vangala Santhosh Reddy, M. Kashi Reddy, Ahmed Kamal, Nishant Jain, Sumit S. Chourasiya, G. Bharath Kumar
Publikováno v:
RSC Advances. 5:97367-97380
A series of new (Z)-3-(arylamino)-1-(2-(arylamino)pyridin-3-yl)prop-2-en-1-one conjugates 9a–p were synthesized and evaluated for their cytotoxic activity against some human cancer cell lines. Some of the treated compounds like 9a, 9g and 9j showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e83d95f4d5e39e2ba577d336510fbb10
https://doi.org/10.1039/c5ra19468g
https://doi.org/10.1039/c5ra19468g