Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha

Autor: Manasi Deshpande, Charles Ramassamy, M.R. Ven Murthy, Prabhakar K. Ranjekar

Publikováno v: Central Nervous System Agents in Medicinal Chemistry. 10:238-246

Ayurveda is a Sanskrit word, which means "the scripture for longevity". It represents an ancient system of traditional medicine prevalent in India and in several other south Asian countries. It is based on a holistic view of treatment which is believ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e17f9ff45d7308e81a15e4279602193e
https://doi.org/10.2174/1871524911006030238

Lipoprotein Lipase Affects the Survival and Differentiation of Neural Cells Exposed to Very Low Density Lipoprotein

Autor: Sébastien Clément, Eric Paradis, M.R. Ven Murthy, Pierre Julien

Publikováno v: Journal of Biological Chemistry. 278:9698-9705

Lipoprotein lipase (LPL) is a key enzyme involved in the metabolism of lipoproteins, providing tissues like adipose tissue or skeletal muscle with fatty acids. LPL is also expressed in the brain, fulfilling yet unknown functions. Using a neuroblastom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac00988bf369756d66ef3c76f27adc2
https://doi.org/10.1074/jbc.m208452200

Detection of the peripheral nervous system (PNS)-type glial fibrillary acidic protein (GFAP) and its mRNA in human lymphocytes

Autor: B. Rolland, Georges Lévesque, M.R. Ven Murthy, Marcienne Tardy, Hélène Riol

Publikováno v: Journal of Neuroscience Research. 48:53-62

Glial fibrillary acidic protein (GFAP), an astroglial marker, has been detected in the peripheral nervous system (PNS) in a shorter version and its mRNA in a longer form (beta-type) than the brain alpha-type. To determine the characteristics of the G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fdf5a6f7b4a236f202ddfdc08b5bb2
https://doi.org/10.1002/(sici)1097-4547(19970401)48:1<53::aid-jnr5>3.0.co

A Mutation in the Human Lipoprotein Lipase Gene as the Most Common Cause of Familial Chylomicronemia in French Canadians

Autor: M.R. Ven Murthy, Michael R. Hayden, Howard E. Henderson, Paul J. Lupien, Pierre Julien, Ghislaine Roederer, Claude Gagné, Jean Davignon, Lorne A. Clarke, Maria V. Monsalve, John D. Brunzell, Yuanhong Ma, Marie Lambert, Thierry Normand

Publikováno v: New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 1991, 324 (25), pp.1761-1766. ⟨10.1056/NEJM199106203242502⟩
Scopus-Elsevier

Lipoprotein lipase hydrolyzes the triglyceride core of chylomicrons and very-low-density lipoproteins and has a crucial role in regulating plasma lipoprotein levels. Deficiencies of lipoprotein lipase activity lead to aberrations in lipoprotein level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5600beef0288f7790660aeac7d633b1d
https://doi.org/10.1056/nejm199106203242502

Requirement for enzymatically active lipoprotein lipase in neuronal differentiation: a site-directed mutagenesis study

Autor: Pierre Julien, M.R. Ven Murthy, Eric Paradis

Publikováno v: Brain research. Developmental brain research. 149(1)

Lipoprotein lipase (LPL) is well known for its role in the catabolism of plasma triglyceride (Tg)-rich lipoproteins, such as very low density lipoproteins (VLDL) and chylomicrons. The action of LPL on Tg-rich lipoproteins provides free fatty acids to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50fb0813be8b136cf14514a5bbd2a1c
https://pubmed.ncbi.nlm.nih.gov/15013626