Zobrazeno 1 - 10 of 214 pro vyhledávání: '"M.P. Lawton"'
1
Cloning and sequencing of flavin-containing monooxygenases FMO3 and FMO4 from rabbit and characterization of FMO3
Autor: V.L. Burnett, Richard M. Philpot, M.P. Lawton
Publikováno v: Journal of Biological Chemistry. 269:14314-14322
The flavin-containing monooxygenases (FMO) are a family of enzymes that contain putative FAD- and NADPH-binding domains within the first 200 residues of their N termini. The cDNAs encoding these enzymes contain an area of relatively high identity ove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b58eea83338114236b399e93e1bf7c79
https://doi.org/10.1016/s0021-9258(17)36791-1
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2
Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase 1C1. Evidence for a third gene subfamily in rabbits
Autor: Richard M. Philpot, E. Atta-Asafo-Adjei, M.P. Lawton
Publikováno v: Journal of Biological Chemistry. 268:9681-9689
Two full-length cDNA clones (2.2 kilobases) encoding a newly recognized form of mammalian flavin-containing monooxygenase (FMO) have been isolated from independent libraries constructed with mRNA from different rabbits. The cDNAs encode a polypeptide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ccb37f6e04857c35c29dba17ad058aa
https://doi.org/10.1016/s0021-9258(18)98403-6
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3
Functional characterization of flavin-containing monooxygenase 1B1 expressed in Saccharomyces cerevisiae and Escherichia coli and analysis of proposed FAD- and membrane-binding domains
Autor: M.P. Lawton, Richard M. Philpot
Publikováno v: Journal of Biological Chemistry. 268:5728-5734
A cDNA encoding the flavin-containing monooxygenase of rabbit lung (FMO 1B1) was expressed in yeast and Escherichia coli and the recombinant enzymes characterized. A high copy, isopropyl-1-thio-beta-D-galactopyranoside (IPTG)-inducible E. coli expres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70dc42d4b8b9a6111365f3a56b37034b
https://doi.org/10.1016/s0021-9258(18)53379-2
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5
The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes
Autor: Richard M. Philpot, Ronald E. Tynes, M.P. Lawton, E Hodgson, Rodolfo Gasser
Publikováno v: Journal of Biological Chemistry. 265:5855-5861
Preparations of mRNA isolated from rabbit lung and liver were used in the construction of libraries that were screened for cDNAs encoding the pulmonary or hepatic isozyme of the flavin-containing monooxygenase. The hepatic library was screened with c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b742cdb25f2df019d11b1d833c9fbae
https://doi.org/10.1016/s0021-9258(19)39441-4
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6
Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: studies with rabbit FMO1, FMO2, FMO3, and FMO5 expressed in Escherichia coli
Autor: R. M. Philpot, M.P. Lawton, A. J. M. Sadeque, Allan E. Rettie, G. P. Meier
Publikováno v: Archives of biochemistry and biophysics. 311(2)
Multiple forms of the microsomal flavin-containing monooxygenase (FMO) exist in rabbit tissues. In order to better understand the catalytic properties of these isoforms, we have expressed rabbit FMO1, FMO2, FMO3, and FMO5 in Escherichia coli and exam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37aef7c0d46b7c6490baa37c828706d6
https://pubmed.ncbi.nlm.nih.gov/8203899
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7
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities
Autor: Colin T. Dolphin, L.L. Poulsen, T. Kimura, J. Ozols, Elizabeth A. Shephard, Richard M. Philpot, A.E. Rettie, David E. Williams, D.M. Ziegler, Ronald N. Hines, E. Hodgson, M.P. Lawton, T. Cresteil, Ian Phillips, Adnan A. Elfarra, John R. Cashman
Publikováno v: Archives of biochemistry and biophysics. 308(1)
A nomenclature based on comparisons of amino acid sequences is proposed for the members of the mammalian flavin-containing monooxygenase (FMO) gene family. This nomenclature is based on evidence of a single gene family composed of five genes. The per
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c70e12bf21407215cc3e407139e5c4
https://pubmed.ncbi.nlm.nih.gov/8311461
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8
Primary Structures and Regulation of Cytochrome P-450 Isozymes 2 (IIB) And 5 (IVB) and the Flavin-Containing Monooxygenase in Rabbit Liver and Lung
Autor: Rodolfo Gasser, Richard M. Philpot, M.P. Lawton
Publikováno v: Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds ISBN: 9781468472868
Cytochrome P-450 (P-450) isozymes 2 and 5, which belong to P-450 gene subfamilies IIB and IVB according to the nomenclature devised by Nebert et al. (1), comprise over 90% of the P-450 in rabbit lung and are the major drug-metabolizing enzymes in tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d526f6cea49c3afd54d4d88e050d3ba4
https://doi.org/10.1007/978-1-4684-7284-4_4
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9
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10
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