Výsledky vyhledávání - "M.M. de Planque"

Pharmacokinetics of 4′-epi-doxorubicin in man

Autor: M.M. De Planque, Jan Lankelma, Paul G.M. Penders, J.G. McVie, W.W. ten Bokkel Huinink, Herbert M. Pinedo, H. Weenen

Publikováno v: Investigational New Drugs. 1:59-64

The pharmacokinetics of 4'-epi-doxorubicin (4'-epi-adriamycin, 4'-epi-DX) in man can be described by a three-compartment model with a rapid distribution phase and a very long elimination phase. Urine excretion amounts to a total of about 11% of the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1e09ee5cba805c824d289736dafd9b
https://doi.org/10.1007/bf00180192

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Pharmacokinetics of mitoxantrone in humans following single-agent infusion or intra-arterial injection therapy or combined-agent infusion therapy

Autor: I.E. Smith, M.M. De Planque, A. van Oosterom, T. J. Schoemaker, J. G. McVie, S. Van Belle, W. Deneve

Publikováno v: Cancer Chemotherapy and Pharmacology. 18:27-32

This study describes the pharmacokinetics of mitoxantrone determined by a sensitive and specific HPLC-method. The time-concentration curves of i.v.-treated patients (15 mg/m2 over 30 min) correspond to a three-compartment model with a T1/2 alpha of 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01edc349879050207b4f28ca2e2e5696
https://doi.org/10.1007/bf00253059

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Pharmacokinetics of carminomycin in Man: Biweekly schedule vs single dose every three weeks

Autor: Jan Lankelma, M.M. De Planque, W.W. ten Bokkel Huinink, J.G. McVie, H.M. Pinedo, H. Weenen

Publikováno v: European Journal of Cancer and Clinical Oncology, 20(7), 915-918. Pergamon Press
Weenen, H, Pinedo, H M, de Planque, M M, ten Bokkel Huinink, W W, McVie, J G & Lankelma, J 1984, ' Pharmacokinetics of carminomycin in Man: Biweekly schedule vs single dose every three weeks ', European Journal of Cancer and Clinical Oncology, vol. 20, no. 7, pp. 915-918 .

Carminomycin was administered to five patients at a dose of 7.5 mg/m 2 twice weekly. Plasma and urine samples were obtained during two subsequent 72-hr periods following drug administration, and assayed for carminomycin (C) and carminomycinol (Col) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2dc925b5563ca699dc8e6dbdd6ba6e
https://research.vumc.nl/en/publications/aa856690-eff8-44fd-80a3-4eb6e3307bb2

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Thyroid function in leukaemia patients after allogeneic bone marrow transplantation

Autor: M. Frölich, B.M. Goslings, M.M. de Planque, A.E. Meinders

Publikováno v: Clinica chimica acta; international journal of clinical chemistry. 165(2-3)

The thyroid function of 29 patients who underwent allogeneic bone marrow transplantation preceded by total body irradiation was followed closely during four weeks after transplantation. Twenty patients showed a marked decrease of T3 and TSH levels, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0d6b3897abc26f7b74a06367692c22
https://pubmed.ncbi.nlm.nih.gov/3308179

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Plasma concentrations of carminomycin and carminomycinol in man, measured by high pressure liquid chromatography

Autor: Jan Lankelma, Herbert M. Pinedo, A. Leyva, M.M. De Planque, Paul G.M. Penders, J.G. McVie, W. W. ten Bokkel-Huinink

Publikováno v: European Journal of Cancer and Clinical Oncology, 18. Pergamon Press
Lankelma, J, Penders, P G M, McVie, J G, Leyva, A, ten Bokkel Huinink, W W, de Planque, M M & Pinedo, H M 1982, ' Plasma concentrations of carminomycin and carminomycinol in man, measured by high pressure liquid chromatography ', European Journal of Cancer and Clinical Oncology, vol. 18, pp. 363 .

In 9 patients with advanced malignant disease who received carminomycin (CMM) in an i.v. bolus injection (dose 18 mg / m 2 ), curves of plasma concentrations of CMM and carminomycinol (CMMOH), a metabolite, versus time were constructed. For determina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf579ca6251ccc1f54e4fd3b348fdae9
https://research.vumc.nl/en/publications/f831f4fb-4324-4e89-b19f-8dda2e84221a

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