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Incorporation of Biologic Response Variance Modeling Into the Clinic: Limiting Risk of Brachial Plexopathy and Other Late Effects of Breast Cancer Proton Beam Therapy

Autor: Nicholas B. Remmes, Robert W. Mutter, Jason K. Viehman, Chris Beltran, Stephanie M. Wick, Dean A. Shumway, Kimberly S. Corbin, Krishan R. Jethwa, M.M. Kahila, Sean S. Park, Thomas J. Whitaker, Hok Seum Wan Chan Tseung

Publikováno v: Practical radiation oncology

Purpose The relative biologic effectiveness (RBE) rises with increasing linear energy transfer toward the end of proton tracks. Presently, there is no consensus on how RBE heterogeneity should be accounted for in breast cancer proton therapy treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99a24f89c75f581b3381f85eded02b7
https://doi.org/10.1016/j.prro.2019.08.011

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Patient-reported outcomes of catheter-based accelerated partial breast brachytherapy and whole breast irradiation, a single institution experience

Autor: Kathryn J. Ruddy, Kristin C. Mara, Tina J. Hieken, Kimberly S. Corbin, Jeff A. Sloan, David M. Routman, Robert W. Mutter, M.M. Kahila, William S. Harmsen, Krishan R. Jethwa, Sean S. Park, Geralyn M. Pumper

Publikováno v: Breast Cancer Research and Treatment. 169:189-196

Accelerated partial breast irradiation (APBI) and whole breast irradiation (WBI) are treatment options for early-stage breast cancer. The purpose of this study was to compare patient-reported-outcomes (PRO) between patients receiving multi-channel in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7920825a49e6612c265ba1cfbb29115d
https://doi.org/10.1007/s10549-018-4665-6

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Abstract P1-10-09: Delineation of internal mammary nodal target volumes in breast cancer radiotherapy

Autor: Kimberly S. Corbin, M.M. Kahila, S.S. Park, LC Brown, Elizabeth Yan, Judy C. Boughey, Robert W. Mutter, Krishan R. Jethwa, Katie N. Hunt

Publikováno v: Cancer Research. 77:P1-10

Purpose/Objectives: The optimal clinical target volume (CTV) for internal mammary node irradiation (IMNI) is uncertain in an era of increasingly conformal volume-based treatment planning for breast cancer. We mapped the location of gross internal mam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19239750e09c5eccea6e43622ea9bb7a
https://doi.org/10.1158/1538-7445.sabcs16-p1-10-09

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ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Autor: Jia Yu, M.M. Kahila, Krishna R. Kalari, Jann N. Sarkaria, Qin Zhou, Robert W. Mutter, William S. Harmsen, Xinyi Tu, Liewei Wang, Matthew P. Goetz, Zhenkun Lou, Judy C. Boughey, Jian Yuan

Publikováno v: Molecular cancer therapeutics. 17(11)

Triple-negative breast cancer (TNBC) is characterized by elevated locoregional recurrence risk despite aggressive local therapies. New tumor-specific radiosensitizers are needed. We hypothesized that the ATR inhibitor, VX-970 (now known as M6620), wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d4371fdaec84563253a9d6c8a90d00
https://pubmed.ncbi.nlm.nih.gov/30166399

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Immediate tissue expander or implant-based breast reconstruction does not compromise the oncologic delivery of post-mastectomy radiotherapy (PMRT)

Autor: Judy C. Boughey, Krishan R. Jethwa, William S. Harmsen, Thomas J. Whitaker, Elizabeth Yan, M.M. Kahila, Valerie Lemaine, Robert W. Mutter, Kimberly S. Corbin, Sean S. Park

Publikováno v: Breast cancer research and treatment. 164(1)

Increasingly, women are choosing immediate breast reconstruction (IBR) following mastectomy. Reports have indicated IBR may compromise post-mastectomy radiotherapy (PMRT). We investigated the impact of IBR on timing of PMRT, target coverage, and dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90069ea19d543ac727d86e6db1caebcd
https://pubmed.ncbi.nlm.nih.gov/28417333

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PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Autor: Robert W. Mutter, Somaira Nowsheen, Qin Zhou, Hu Li, Ping Yin, Bo Qin, Yong Zhang, M.M. Kahila, Cheng Zhang, Jiaqi Liu, Jian Yuan, Huadong Pei, Xinyi Tu, Jia Yu, Fei Zhao, Zhenkun Lou, Haidong Dong, Zhiwang Song, Chao Zhang

Publikováno v: Mol Cell

Programmed death ligand 1 (PD-L1, also called B7-H1) is an immune checkpoint protein that inhibits immune function through its binding of the programmed cell death protein 1 (PD-1) receptor. Clinically approved antibodies block extracellular PD-1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c915adec7f36f8fc105246a1a90973c5
https://doi.org/10.1016/j.molcel.2019.04.005

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Initial clinical experience of postmastectomy intensity modulated proton therapy in patients with breast expanders with metallic ports

Autor: Sean S. Park, Robert W. Mutter, Nicholas B. Remmes, Kimberly S. Corbin, Elizabeth Yan, Yan Zhang, Judy C. Boughey, Chris Beltran, Kathy A. Hoeft, Deanna H. Pafundi, M.M. Kahila, Valerie Lemaine

Publikováno v: Practical radiation oncology. 7(4)

Purpose The feasibility of proton postmastectomy radiation therapy in patients reconstructed with expanders has not been previously reported, limiting treatment options. We analyzed the dosimetric impact of the metallic port contained within expander

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199657671932a1edcb15b9e4f4038a24
https://pubmed.ncbi.nlm.nih.gov/28341315

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Delineation of Internal Mammary Nodal Target Volumes in Breast Cancer Radiation Therapy

Autor: Judy C. Boughey, Lindsay C. Brown, Robert W. Mutter, Elizabeth Yan, Kimberly S. Corbin, Katie N. Hunt, M.M. Kahila, Krishan R. Jethwa, Sean S. Park

Publikováno v: International journal of radiation oncology, biology, physics. 97(4)

Purpose The optimal clinical target volume for internal mammary (IM) node irradiation is uncertain in an era of increasingly conformal volume-based treatment planning for breast cancer. We mapped the location of gross internal mammary lymph node (IMN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763f08454837fe52bff25b2f93529d50
https://pubmed.ncbi.nlm.nih.gov/28244412

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