Zobrazeno 1 - 10 of 44 pro vyhledávání: '"M.M. Ewing"'
1
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases
Autor: Ewa Ninio, J.W. Jukema, Erna Peters, James R. Mitchell, S.A.P. Karabina, Johan Frostegård, R.C.M. Jong, A. Bergman, Margreet R. de Vries, I. Dahlbom, Michael R MacArthur, M.M. Ewing, M. Nordzell, D.J. Sexton, J.C. Karper, Paul H.A. Quax, Knut Pettersson, J. Kuiper
Publikováno v: Journal of Internal Medicine, 290 (1)
Journal of Internal Medicine, 290(1), 141-156. WILEY
Journal of Internal Medicine
Journal of Internal Medicine, Wiley, 2020, ⟨10.1111/joim.13234⟩
Background Phosphorylcholine (PC) is an important pro‐inflammatory damage‐associated molecular pattern. Previous data have shown that natural IgM anti‐PC protects against cardiovascular disease. We aimed to develop a monoclonal PC IgG antibody
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63977bd8d6d72a00632bfb05a3ee8956
https://hdl.handle.net/20.500.11850/465611
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2
Akademický článek
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3
The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development
Autor: H.A.B. Peters, Fabiana Baghana, J. Wouter Jukema, M.M. Ewing, Peter J. van den Elsen, Paul H.A. Quax, A.J.N.M. Bastiaansen, Céline Gongora, Rob C. M. de Jong, J.C. Karper, Margreet R. de Vries
Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185820 (2017)
PLOS ONE
PLoS ONE, 12(10)
PLoS ONE, 12(10):e0185820. Public Library of Science
PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0185820. ⟨10.1371/journal.pone.0185820⟩
De Jong, R C M, Ewing, M M, De Vries, M R, Karper, J C, Bastiaansen, A J N M, Peters, H A B, Baghana, F, Van Den Elsen, P J, Gongora, C, Jukema, J W & Quax, P H A 2017, ' The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development ', PLoS ONE, vol. 12, no. 10, e0185820 . https://doi.org/10.1371/journal.pone.0185820
Objective Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor kappa-beta (NFκB)-mediated inflammation, which drives post-interventional intim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c28bcb9a2c8fdbd3de47f9c5490b84
http://europepmc.org/articles/PMC5634597?pdf=render
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4
Future potential biomarkers for postinterventional restenosis and accelerated atherosclerosis
Autor: Johan Wouter Jukema, Paul H.A. Quax, M.M. Ewing, J.C. Karper
Publikováno v: Biomarkers in Medicine, 6(1), 53-66
New circulating and local arterial biomarkers may help the clinician with risk stratification or diagnostic assessment of patients and selecting the proper therapy for a patient. In addition, they may be used for follow-up and testing efficacy of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bd218ac16435e0b80ba535f7e50be9
https://doi.org/10.2217/bmm.11.107
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5
Genetic determinants of adverse outcome (restenosis, malapposition and thrombosis) after stent implantation
Autor: Paul H.A. Quax, J. Wouter Jukema, M.M. Ewing, Orçun Özsoy, Douwe Pons, Ioannis Karalis, Sandrin C. Bergheanu, Jeffrey J. W. Verschuren
Publikováno v: Interventional Cardiology. 2:147-157
Despite its unequivocal superiority compared with balloon angioplasty, coronary stenting did not abolish the restenosis problem and even brought along a completely new type of pathology. Bare-metal stents still associate with an approximate 20–30%
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7386aacdd779e0ac1fa965b0a261c6aa
https://doi.org/10.2217/ica.10.9
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6
An Unexpected Intriguing Effect of Toll-Like Receptor Regulator RP105 (CD180) on Atherosclerosis Formation With Alterations on B-Cell Activation
Autor: Christoph J. Binder, P.J. van Santbrink, Joop Jukema, Ziad Mallat, J.C. Karper, Ilze Bot, Johan Kuiper, Paul H.A. Quax, M.R. de Vries, M.M. Ewing, Anke Redeker, Ramon Arens, S.C.A. de Jager
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology, 33(12), 2810-2817
Objective— In atherosclerosis, Toll-like receptors (TLRs) are traditionally linked to effects on tissue macrophages or foam cells. RP105, a structural TLR4 homolog, is an important regulator of TLR signaling. The effects of RP105 on TLR signaling v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666eef2cb3a6aa9ef8565718d5558f96
http://hdl.handle.net/1887/102251
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8
Lysine Acetyltransferase PCAF Is a Key Regulator of Arteriogenesis
Autor: J. Wouter Jukema, M.M. Ewing, Erna Peters, Tineke C. T. M. van der Pouw Kraan, A.J.N.M. Bastiaansen, Jaap F. Hamming, Hetty C. de Boer, Sabine M.J. Welten, Margreet R. de Vries, Scott M. Moore, A. Yaël Nossent, Ramon Arens, James E. Faber, Paul H.A. Quax
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology, 33(8), 1902-1910
Arteriosclerosis, Thrombosis, and Vascular Biology, 33(8), 1902-1910. Lippincott Williams and Wilkins
Bastiaansen, A J N M, Ewing, M M, de Boer, HC, van der Pouw Kraan, C T M, de Vries, M R, Peters, E A B, Welten, S M J, Arens, R, Moore, S M, Faber, J E, Jukema, J W, Hamming, J F, Nossent, A Y & Quax, P H A 2013, ' Lysine Acetyltransferase PCAF Is a Key Regulator of Arteriogenesis ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, no. 8, pp. 1902-1910 . https://doi.org/10.1161/ATVBAHA.113.301579
Objective— Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd68d7d3688df6092bcbecdb818efb45
http://hdl.handle.net/1887/105860
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9
RP105 (cd180) as a TLR-4 regulator ameliorates atherosclerosis via its role on B-cells
Autor: M.M. Ewing, Pha Quax, Ilze Bot, M.R. de Vries, Johan Kuiper, J.C. Karper, Ramon Arens, Johan Wouter Jukema, S.C.A. de Jager
Publikováno v: European Heart Journal, 34, 441-441
Background: Toll Like Receptors (TLR) are major contributors to cardiovascular disease development and TLR4 is strongly involved in atherosclerosis. RP105, a structural TLR4 homolog, is an important regulator of TLR4 signaling. RP105 dampens the TLR4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e0c3833fec6ed521f5dc94b5d943c5
http://hdl.handle.net/1887/102406
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10
TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation
Autor: T. Harma C. Brondijk, Erna Peters, J. Wouter Jukema, M.M. Ewing, Hetty C. de Boer, Margreet R. de Vries, Saskia C. A. de Jager, Anton Jan van Zonneveld, Eric G. Huizinga, Johan Kuiper, J.C. Karper, Paul H.A. Quax
Publikováno v: PLoS ONE, Vol 8, Iss 7, p e67923 (2013)
PLoS ONE, 8(7)
PLoS ONE
PLoS ONE, 8(7), e67923
PLoS One, 8(7), 1. Public Library of Science
Background RP105 (CD180) is TLR4 homologue lacking the intracellular TLR4 signaling domain and acts a TLR accessory molecule and physiological inhibitor of TLR4-signaling. The role of RP105 in vascular remodeling, in particular post-interventional re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0b6cb39aa3623b5c70575514fefa8f
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23844130/pdf/?tool=EBI
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