Zobrazeno 1 - 10 of 15 pro vyhledávání: '"M.J. Saltarelli"'
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Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study
Autor: J.K. Medema, S.B. Abramson, Mukundan Attur, Morten Karsdal, P. Jiang, M.J. Saltarelli, F. Hong, B.A. Hendrickson, S.X. Wang, Matthew P. Kosloski, Richard A. Preston, Carlos J. Lozada
Publikováno v: Osteoarthritis and Cartilage. 25:1952-1961
Summary Objective To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ABT-981, a human dual variable domain immunoglobulin simultaneously targeting interleukin (IL)-1α and IL-1β, in patients with knee osteoarthritis (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a13d96a74e36fcdde53876e20f7d34c
https://doi.org/10.1016/j.joca.2017.09.007
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2
A Rev Protein Is Expressed in Caprine Arthritis Encephalitis Virus (CAEV)-Infected Cells and Is Required for Efficient Viral Replication
Autor: M.J. Saltarelli, Janice E. Clements, R.V. Schoborg
Publikováno v: Virology. 202:1-15
Caprine arthritis encephalitis virus (CAEV) is a lentivirus that is closely related to visna virus and more distantly related to the human lentivirus human immunodeficiency virus 1 (HIV-1). Like other lentiviruses, the genome of CAEV contains multipl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c91f54a65ef0f60e40b7564a339f621
https://doi.org/10.1006/viro.1994.1316
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3
THU0491 Dual Variable Domain-Immunoglobulin (DVD-IG™) ABT-981 Simultaneously and Dose-Dependently Inhibits Interleukin-1 Alpha and -1 Beta in Subjects with Knee Osteoarthritis
Autor: S.X. Wang, R. Loebbert, M.J. Saltarelli, J.K. Medema, E.R. Sampson, F. Hong
Publikováno v: Annals of the Rheumatic Diseases. 74:377.2-378
Background ABT-981 is a novel human Dual-Variable Domain Immunoglobulin (DVD-Ig™) that inhibits interleukin (IL)-1α and IL-1β. Objectives To evaluate IL-1α and IL-1β protein levels in serum, and IL-1α, IL-1β, and IL-1Ra (IL-1 receptor antagon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fd65e3ed76495e32191abf7a50938ac
https://doi.org/10.1136/annrheumdis-2015-eular.5091
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4
SAT0448 Interleukin-1 Dual Variable–Domain Immunoglobulin Reduces Multiple Imflammatory Markers in Knee Osteoarthritis Patients
Autor: J.K. Medema, Matthew P. Kosloski, Morten Karsdal, M.J. Saltarelli, Wei Liu, S.X. Wang
Publikováno v: Annals of the Rheumatic Diseases. 73:756.1-756
Background Osteoarthritis (OA) may comprise multiple phenotypes, one of which is inflammation-driven OA. Consequently, a selected subpopulation of OA patients may benefit from optimally targeted anti-inflammatory treatment. Interleukin-1 (IL-1) is a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ae6e49a033ff0e1394b765dee312c1d
https://doi.org/10.1136/annrheumdis-2014-eular.5528
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5
Analysis of human immunodeficiency virus type 1 mRNA splicing patterns during disease progression in peripheral blood mononuclear cells from infected individuals
Autor: M.J. Saltarelli, T.J. Spira, Barbara K. Felber, C.E. Hart, Jeanette Harrison, Emilia Hadziyannis, G. N. Pavlakis
Publikováno v: AIDS research and human retroviruses. 12(15)
HIV-1 produces more than 20 mRNAs encoding the viral proteins. We have used a sensitive reverse transcriptase-polymerase chain reaction (RT-PCR) approach to determine HIV-1 transcriptional patterns during the course of viral infection in unstimulated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e917634810576281e53d3b0795144a
https://pubmed.ncbi.nlm.nih.gov/8893052
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6
Identification of the caprine arthritis encephalitis virus Rev protein and its cis-acting Rev-responsive element
Autor: M.J. Saltarelli, Janice E. Clements, George N. Pavlakis, R. Schoborg
Publikováno v: Virology. 199(1)
Caprine Arthritis Encephalitis Virus (CAEV) is a lentivirus closely related to visna virus of sheep and more distantly related to the human lentivirus HIV-1. The genomes of lentiviruses contain additional genes that regulate the lentivirus gene expre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94629548b3fda3ef4b1506a31a987a06
https://pubmed.ncbi.nlm.nih.gov/8116254
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7
The CAEV tat gene trans-activates the viral LTR and is necessary for efficient viral replication
Autor: M.J. Saltarelli, Janice E. Clements, R. Schoborg, S.L. Gdovin
Publikováno v: Virology. 197(1)
Caprine arthritis-encephalitis virus (CAEV) is a lentivirus which is closely related by nucleotide sequence and biological properties to visna virus. Sequence analysis of the CAEV genome revealed the presence of a small open reading frame (ORF) which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c3eb83d79f9c99c8002d59dbb8dd25
https://pubmed.ncbi.nlm.nih.gov/8212571
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8
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