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Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively

Autor: Walter van Rotterdam, Inez M.J. Meijer, Jeroen E.M. van Leeuwen, Everardus J.J. van Zoelen

Publikováno v: Cellular Signalling, 25, 2, pp. 470-478
Cellular Signalling, 25, 470-478

ERBB receptors have an important function in mammalian development and normal physiology, but overexpression and poor downregulation of ERBB receptors have been associated with malignant growth. Ligand-induced ERBB receptor signaling is terminated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6557be12b8659969e41d2aabe18b4f89
https://hdl.handle.net/2066/103221

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Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH

Autor: Jeroen E.M. van Leeuwen, Inez M.J. Meijer, Everardus J.J. van Zoelen, Walter van Rotterdam

Publikováno v: Cellular Signalling, 24, 1981-1988
Cellular Signalling, 24, pp. 1981-1988

ErbB receptors play an important role in normal cellular growth, differentiation and development, but overexpression or poor downregulation can result in enhanced signaling and cancerous growth. ErbB signaling is terminated by clathrin-dependent rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c279172898c720d557c05eff226258bc
https://hdl.handle.net/2066/103684

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ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site

Autor: Everardus J.J. van Zoelen, Ester Damen, Laura S. Sleumer, Suzanne M. Jansen, Jeroen E.M. van Leeuwen, Inez M.J. Meijer

Publikováno v: Cellular Signalling, 21, 810-818
Cellular Signalling, 21, 5, pp. 810-818

Poor downregulation of ErbB receptors is associated with enhanced downstream signaling and tumorigenesis. It has been suggested that poor downregulation of ErbB-2, -3 and -4 receptors when compared to ErbB1 is due to decreased recruitment of Cbl E3 l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8774de52edcd05684d1b09511903e0
https://hdl.handle.net/2066/75956

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The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation

Autor: Inez M.J. Meijer, JoAnn Kerperien, Everardus J.J. van Zoelen, Jeroen E.M. van Leeuwen, Ana M. Sotoca

Publikováno v: Cellular Signalling, 25, 919-30
Cellular Signalling, 25, 4, pp. 919-30

The ERBB1-ERBB4 receptors belong to a family of receptor tyrosine kinases that trigger a network of signaling pathways after ligand binding, thereby regulating cellular growth, differentiation and development. Ligand-induced signaling through ERBB1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33797842dabf1a44b599966e1d53763
http://hdl.handle.net/2066/111442

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ERBB2 is a target for USP8-mediated deubiquitination

Autor: Inez M.J. Meijer, Jeroen E.M. van Leeuwen

Publikováno v: Cellular Signalling, 23, 2, pp. 458-467
Cellular Signalling, 23, 458-467

Overexpression and poor downregulation of ErbB receptor tyrosine kinases are associated with enhanced signaling and tumorigenesis. Attenuation of EGF-receptor (EGFR) signaling is mediated by endocytosis and ubiquitination by the E3-ligase Cbl. En rou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bf9ef175c4784e3697c25c00347075
https://pubmed.ncbi.nlm.nih.gov/21044682

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Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling

Autor: Sabine Tejpar, René J. M. Bindels, Jenny van der Wijst, Harry van Goor, Gemma M. Mulder, Joost G. J. Hoenderop, Todd Alexander, Henrik Dimke, Inez M.J. Meijer

Publikováno v: Dimke, H A, van der Wijst, J, Alexander, T R, Meijer, I M J, Mulder, G M, van Goor, H, Tejpar, S, Hoenderop, J G & Bindels, R J 2010, ' Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling ' Journal of the American Society of Nephrology, vol. 21, no. 8, pp. 1309-16 . https://doi.org/10.1681/ASN.2009111153
Journal of the American Society of Nephrology, 21, 1309-16
Journal of the American Society of Nephrology, 21(8), 1309-1316. AMER SOC NEPHROLOGY
Journal of the American Society of Nephrology, 21, 8, pp. 1309-1316
Journal of the American Society of Nephrology, 21, 8, pp. 1309-16
Journal of the American Society of Nephrology, 21, 1309-1316

Contains fulltext : 88763.pdf (Publisher’s version ) (Open Access) A mutation in pro-EGF causes isolated hypomagnesemia, and monoclonal antibodies targeting the extracellular domain of the EGF receptor (EGFR) affect epithelial Mg(2+) transport. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018cc820118d89ceec72a1a0110616c1
https://pure.au.dk/portal/da/publications/effects-of-the-egfr-inhibitor-erlotinib-on-magnesium-handling(df785701-1c80-4397-8366-353242edc67c).html

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