Zobrazeno 1 - 10
of 37
pro vyhledávání: '"M.J. García-Meseguer"'
Autor:
Ramón Varón, Enrique Arribas, M.J. García-Meseguer, J. M. Villalba, Francisco García-Sevilla, Rubén Díaz-Sierra, Antonio J. Barbero, J. A. Vidal De Labra, Manuela García-Moreno
Publikováno v:
Journal of Computational Chemistry. 32:915-931
Deriving mean residence times (MRTs) is an important task both in pharmacokinetics and in multicom- partmental linear systems. Taking as starting point the analysis of MRTs in open or closed (Garcia-Meseguer et al., Bull Math Biol 2003, 65, 279) mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3d94dcc560c703d2685bd871e30992
https://doi.org/10.1002/jcc.21677
https://doi.org/10.1002/jcc.21677
Autor:
Manuela García-Moreno, M.J. García-Meseguer, Bent H. Havsteen, J. A. Vidal De Labra, Ramón Varón, F. García-Cánovas
Publikováno v:
Bulletin of Mathematical Biology. 65:279-308
A complete analysis has been performed of the mean residence times in linear compartmental systems, closed or open, with or without traps and with zero input. This analysis allows the derivation of explicit and simple general symbolic formulae to obt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623a916845ed158506bedbe71e045a3f
https://doi.org/10.1016/s0092-8240(02)00096-4
https://doi.org/10.1016/s0092-8240(02)00096-4
Autor:
Ramón Varón, F. García-Cánovas, Manuela García-Moreno, J. A. Vidal De Labra, M.J. García-Meseguer, Bent H. Havsteen
Publikováno v:
Biosystems. 59:197-220
In this contribution, we present the symbolic time course equations corresponding to a general model of a linear compartmental system, closed or open, with or without traps and with zero input. The steady state equations are obtained easily from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042b0ce3ebbaefc522922f9beccb82b4
https://doi.org/10.1016/s0303-2647(01)00116-2
https://doi.org/10.1016/s0303-2647(01)00116-2
Publikováno v:
Biosystems. 36:121-133
The derivation of kinetic equations is described for n-compartment linear models, in which the substance may be simultaneously introduced into one or more compartments at t = 0 and eliminated from any compartment. For a given zero-input, general form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5c1ab695be794d6289d3c849b56fe0
https://doi.org/10.1016/0303-2647(95)01533-q
https://doi.org/10.1016/0303-2647(95)01533-q
Publikováno v:
Biosystems. 36:135-144
The final equations obtained in the first article of this series describing the concentrations of substances in any of the compartments of a model are here cast in an easily programable form. A computer program with an easy input method and the abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4667acc5140760ce1f01125a392bd097
https://doi.org/10.1016/0303-2647(95)01536-t
https://doi.org/10.1016/0303-2647(95)01536-t
Autor:
Francisco García-Sevilla, Ramón Varón, Francisco Garcia-Molina, M.J. García-Meseguer, Rubén Díaz-Sierra, J. M. Villalba, Manuela García-Moreno, Enrique Arribas
The symbolic time course equations corresponding to a general model of a linear compartmental system, closed or open, with or without traps and with zero input are presented in this chapter. From here, the steady state equations are obtained easily f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1aac4a80a2fb6cc3af60820ddb7619d
https://doi.org/10.4018/978-1-60960-860-6.ch016
https://doi.org/10.4018/978-1-60960-860-6.ch016
Autor:
Manuela García-Moreno, Bent H. Havsteen, Edelmira Valero, M. Molina, M.J. García Meseguer, R. Varón Castellanos
Publikováno v:
Journal of Theoretical Biology. 157:523-533
A theoretical kinetic analysis of a model, which already has been studied experimentally, is presented. This model describes the action of water soluble lipolytic enzymes on their insoluble substrates. Several particular cases are treated and a proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6a6fe208cba7db94b398e3322d3ba7
https://doi.org/10.1016/s0022-5193(05)80667-8
https://doi.org/10.1016/s0022-5193(05)80667-8
Publikováno v:
Journal of theoretical biology. 245(1)
In the present paper, a kinetic analysis of a general model for proenzyme activation, where the activating enzyme and also the activated one are reversibly inhibited in two steps by two different inhibitors, has been performed. The cases in which bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cc338b6659a99a5358713e6a05b4dd
https://pubmed.ncbi.nlm.nih.gov/17081569
https://pubmed.ncbi.nlm.nih.gov/17081569
Autor:
Manuela García-Moreno, Milagros Molina-Alarcón, Ramón Varón, Edelmira Valero, J. A. Vidal De Labra, M.J. García-Meseguer, F. García-Cánovas, C. Garrido-Del Solo
Publikováno v:
Journal of theoretical biology. 218(3)
Suicide substrates are widely used in enzymology for studying enzyme mechanisms and designing potential drugs. The presence of a reversible modifier decreases or increases the rate of substrate-induced inactivation, with evident physiological and exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472eacd8d97270cbad148e35853770a0
https://pubmed.ncbi.nlm.nih.gov/12381436
https://pubmed.ncbi.nlm.nih.gov/12381436
Publikováno v:
Bio Systems. 36(2)
In this paper, we present an alternative procedure to derive the residence times of enzyme and compartment systems. This procedure allows to express the residence time by a general, symbolic and simplified formula relating it directly with the rate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c8aa89066c490129b05c766fd3556b
https://pubmed.ncbi.nlm.nih.gov/8573695
https://pubmed.ncbi.nlm.nih.gov/8573695