Cytochrome P450 2E1 mRNA in the rat prostate: detection and quantitation by competitive reverse transcription and polymerase chain reaction

Autor: M.J Coon, S.J Pernecky, C.-L Kuo, Walter N. Piper, Y Jiang

Publikováno v: Molecular and cellular probes. 12(5)

Cytochrome P450 2E1 plays a pivotal role in the metabolic activation of a wide variety of low molecular weight environmental toxicants and procarcinogens. In the present study, expression of the P450 2E1 gene in the rat prostate gland was quantitated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c23c973137d98ea2554fcc0ef40ba1
https://pubmed.ncbi.nlm.nih.gov/9778451

The NH2-terminal region of rabbit CYP2E1 is not essential for interaction with NADPH-cytochrome P450 reductase

Autor: John B. Schenkman, M.J. Coon, S.J. Pernecky, A.I. Voznesensky

Publikováno v: Biochemical and biophysical research communications. 203(1)

Recently we reported that electrostatic forces interfere with the formation of the NADPH-cytochrome P450 reductase/cytochrome P450 electron transfer complex and suggested that this complex is formed by the attraction of the complementary hydrophobic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35615d81bfb7cf210e867e56e30865ff
https://pubmed.ncbi.nlm.nih.gov/8074649

Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states

Autor: M.J. Coon, J.L. Vermilion

Publikováno v: Journal of Biological Chemistry. 253:2694-2704

NADPH-cytochrome P-450 reductase was isolated from liver microsomes of phenobarbital-induced rats. The enzyme exhibits an apparent minimal molecular weight of 76,000 as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8296e209db6d893af59d073dbadcd9d4
https://doi.org/10.1016/s0021-9258(17)40876-3

On the mechanism of action of cytochrome P-450. Role of peroxy spectral intermediates in substrate hydroxylation

Autor: R.C. Blake nd, M.J. Coon

Publikováno v: Journal of Biological Chemistry. 256:5755-5763

Cytochrome P-450 functions as an oxygenase in 0 2 and NADPH-dependent substrate hydroxylations and also as a peroxygenase in a variety of peroxide-dependent substrate hydroxylation reactions. As shown previously, peroxy compounds react with the pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1c2a1e4d109f9cda3052621db2ca2f3
https://doi.org/10.1016/s0021-9258(19)69271-9

LIST OF PARTICIPANTS

Autor: Günther Achtert, Moises Agosin., Jorma T. Ahokas, Hans-Jürgen Altmann, Alvito P. Alvares, Pentti I. Arvela, A.J. Baars, Christer Von Bahr, Anne-Marie Batt, Giorgio Belvedere, John R. Bend, Philip Bentley, Anders Berg, Margareta Berggren, Friedrich E. Beyhl, Karl Walter Bock, Irmgard Böttcher, G.S. Boyd, Alasdair M. Breckenridge, G. Brunner, Babette Budczies, Brian Burchell, U. Busch, Jorge Capdevila, Kjell Carlström, Claude Charuel, Arthur K. Cho, Allan H. Conney, Marguerite L. Coomes, M.J. Coon, David Y. Cooper, P.J. Cox, Eva Cremer-Schlede, Donald S. Davies, Marie-Pascale Debey, Helmut Denk, Maurice Dickins, G. Deutschmann, Horst Diehl, Agnès Dietsch, William H. Down, Wilfried Duppel, Karl M. Dus, Erik Dybing, D. Ebel, Anneliese Eben, C.R. Elcombe, Lars Ernster, Ronald W. Estabrook, William E. Fann, Francois Fauran, Erik Fellenius, Michael Franklin, Andreas Garbe, Harry V. Gelboin, J. Gielen, James R. Gillette, Hans R. Glatt, A.J. Glazko, Mario Golan, Roland Gräfström, Theodore E. Gram, I.C. Gunsalus, Jan-Åke Gustafsson, Osmo Hänninen, Richard K. Haroz, Gerhard Heinemeyer, H. Herken, Mala Herzberg, Wolfgang Herzberg, Sigrun Hesse, Alfred Hildebrandt, Masaharo Hirata, P. Hlavica, Harald Hoensch, R.W. Hoffbauer, Johan Högberg, J.L. Holtzman, Heimbert Ihlefeld, Magnus Ingelman-Sundberg, Sten Jakobsson, Rolf Jauch, Elizabeth Jeffery, D. Jerina, Bengt Jernström, Karin Johannesen, Jean-Gil Joly, H.G. Jonen, John Jonsson, Niilo Kärki, G.F. Kahl, Regine Kahl, Laurence Kaminsky, A. Kappas, Ryuichi Kato, Rolf Kaufmann, Helmut Kewitz, Hugo Kexel, Manfred Kiese, Sangduk Kim, Jan Koch-Weser, P. Kremers, David Kupfer, John Chr. Larsen, Matti Lang, John J. Lech, Werner Lenk, Wayne Levin, Charles S. Lieber, Christina Lind, Björn Lindeke, R. Lissner, Klaus Lübke, Mahin D. Maines, G.J. Mannering, Carolyn G. Marlowe, Jukka Marniemi, Marios Marselos, J. Marsh, Bettie Sue S. Masters, Ina E. Mattern, Urs A. Meyer, Michel Mercier, John J. Mieyal, Jerry R. Mitchell, Gertrud Mohn, Peter Moldéus, Maria Moron, Jacqueline Mosser, Robert Mull, Ursula Muller-Eberhard, Skakunthola Narasimhulu, Wolfgang Nastainczyk, Robert Neal, Daniel W. Nebert, K.J. Netter, J. Noordhoek, Raymond F. Novak, Franz Oesch, Kyuichio Okuda, Tsuneo Omura, Sten Orrenius, Terence C. Orton, Beverly Paigen, Kenneth Paigen, D.W. Parke, Andrzey Pawlak, Thomas C. Pederson, Olavi Pelkonen, Julian A. Peterson, Richard M. Philpot, Joseph W. DePierre, Davide Pitré, Jutta Poensgen, G. Powis, Russell A. Prough, Kaija Pyykkö, Joseph James Rafter, Anver Rahimtula, Donald J. Reed, H. Remmer, Slobodan Rendic, Ivar Roots, Otto Rosenthal, Alan Rubin, Hans-Heinrich Ruf, Ryo Sato, John B. Schenkman, M. Scheulen, Heinz Schleyer, H.U. Schmassmann, Eike Schmelz, Jochen Schmid, H.-L. Schmidt, Achim Schmoldt, Klaus Schoene, J. Schoppler, Eric Schreiber, Martin Schulman, Rolf Schulte-Hermann, R. Schüppel, Ingeborg Schuster, Thomas Schwartzkopff, Janeric Seidegard, Helmut Sies, Gérard Siest, Z. Sipal, Stephen G. Sligar, Robert Snyder, Eero A. Sotaniemi, Peter Spitzauer, Hansjürgen Staudinger, A. Stier, Robert Stitzel, Minoru Tanaka, David J. Temple, Cherrie Temple, H.A. Tennekes, Leon C. Terriere, Rolf Teschke, Jean-Paul Thenot, Hjördis Thor, Snorri S. Thorgeirsson, Ronald G. Thurman, Teddy G. Traylor, Patricia S. Traylor, Elisabeth Trifilieff, John C.M. Tsibris, Anders Tunek, Parcor Tuong Chi Cuong, H. Uehleke, Volker Ullrich, Helena Vadi, Kirsi Vähäkangas, Harri Vainio, Kostas P. Vatsis, Elliot S. Vesell, Eila Viljakainen, R. Visser, Manfred Volz, Jean-Pierre Villeneuve, William J. Waddell, Richard M. Welch, Peter Wende, Gemot Wendt, Jürgen Werringloer, Jürgen Weymann, F.J. Wiebel, Roland C. Wolf, Thomas Wolff, Peter Wollenberg, C.S. Yang, Shen K. Yang, Yukio Yasukochi, David W. Yesair, K. Zehnder, Daniel M. Ziegler, Arno Zimmer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e050a8f99921c46a1e2e0b70d2e412a
https://doi.org/10.1016/b978-0-444-86979-1.50006-5