Zobrazeno 1 - 10
of 241
pro vyhledávání: '"M.I. Botez"'
Autor:
M.I. Botez, Robert Lalonde, Caroline Hébert, Tomás A. Reader, C. Strazielle, Laurent Descarries, Ariel R. Ase
Publikováno v:
Synapse. 37:179-193
The autosomal recessive mutation dystonia musculorum (dt(J)/dt(J)) causes degenerative alterations of peripheral and central sensory pathways that lead to ataxia. To investigate possible changes in the central serotonin system of these mice, HPLC mea
Publikováno v:
Brain Research Bulletin. 48:195-201
The Lurcher (Lc/+) mutant mouse is characterized by a considerable atrophy of the cerebellum due to a massive loss of cerebellar Purkinje and granule cells, as well as of neurons from the inferior olivary nucleus. In this study the effects of a thera
Publikováno v:
Neurochemistry International. 32:61-68
Dopamine (DA) uptake sites, or transporters, were examined with [125I]RTI-121 in mutant mice that exhibit motor control deficits, namely weaver, lurcher and dystonia musculorum. In lurcher mice, the distribution of [125I]RTI-121 binding was similar t
Publikováno v:
Archives of Neurology. 54:1030-1033
Background: Neurochemical disorders associated with spinocerebellar ataxias are multiple. Objective: To use replacement and neuroprotective therapy in a case of severe respiratory failure in Friedreich ataxia. Patient and Treatment: A 44-year-old man
Publikováno v:
European Journal of Neurology. 3:89-97
Thirty-two OPCA patients without cortical atrophy were studied. In addition to inspection of films by a neuroradiologist (i.e. “subjective” assessment), five neuroradiological measures were used, namely, the estimation of brainstem ratio, midbrai
Publikováno v:
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 21:353-357
A woman had a left superior cerebellar artery infarct associated with reduced hexamethyl-propileneamine oxime uptake on SPECT scan of the basal ganglia and frontoparietal areas of the opposite hemisphere performed poorly in some neuropsychological te
Publikováno v:
Restorative neurology and neuroscience. 5(5)
The effects of amantadine and ketamine were compared to a placebo in a coat-hanger test on lurcher mutant mice. This test measures motor coordination and is dependent on cerebellar functioning. Both drugs improved motor coordination of the cerebellar
Publikováno v:
Experimental Aging Research. 19:367-376
In this brief review of the possible link between age-related behavioral disorders and brain folate levels, preliminary data on humans and animals are presented. These data indicate that folate administration may improve some age-related behavioral d
Publikováno v:
Physiology & Behavior. 54:41-44
Lurcher mutant mice, a cerebellar mutant displaying ataxia and equilibrium deficits, had fewer hole pokes in a 16-hole matrix than normal mice. Lurcher mutants also took longer to reach a platform from a grid and to begin to climb a grid from the flo
Publikováno v:
Brain Research. 618:19-22
Lurcher mutants were evaluated in the acquisition of a visual discrimination learning task with water escape as a reward. In comparison to normal mice, lurchers were impaired in discrimination learning in a manner not explainable by motor deficits. A