Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients

Autor: Hans M. Schrijver, Thea van Lopik, René A. W. van Lier, H.J. Adèr, Chris H. Polman, M.H.G. Rep, Rogier Q Hintzen, Marijke T. L. Roos

Publikováno v: Journal of Neuroimmunology, 96, 92-100. Elsevier
Journal of neuroimmunology, 96(1), 92-100. Elsevier
Rep, M H G, Schrijver, H M, van Lopik, T, Hintzen, R Q, Roos, M T L, Ader, H J, Polman, C H & van Lier, R A W 1999, ' Interferon (IFN)-beta treatment enhances CD95 and interleukin 10 expression but reduces interferon-gamma producing T cells in MS patients ', Journal of Neuroimmunology, vol. 96, pp. 92-100 . https://doi.org/10.1016/S0165-5728(98)00271-9

Interferon (IFN)-beta has been shown to favorably alter the disease course of relapsing-remitting multiple sclerosis (RRMS) patients. Although its mode of action is still unclear, there is ample evidence from in vitro studies that IFN-beta directly m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86501e2cca7bf401bde1819fdbd99e18
https://doi.org/10.1016/s0165-5728(98)00271-9

Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans

Autor: R. A. W. Van Lier, Chris H. Polman, Marijke T. L. Roos, M.H.G. Rep, Herman J. Adèr, B.W. van Oosten

Publikováno v: Rep, M H G, Van Oosten, B W, Roos, M T L, Adèr, H J, Polman, C H & Van Lier, R A W 1997, ' Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-γ secreting TH1 cells in humans ', Journal of Clinical Investigation, vol. 99, no. 9, pp. 2225-2231 . https://doi.org/10.1172/JCI119396
The journal of clinical investigation, 99, 2225-2231. The American Society for Clinical Investigation
Journal of Clinical Investigation, 99(9), 2225-2231. The American Society for Clinical Investigation
Journal of clinical investigation, 99(9), 2225-2231. The American Society for Clinical Investigation

CD4(pos) TH1 T cells are considered to play a central role in a number of human autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis. Experimental treatment protocols aimed at selectively eliminating CD4(pos) T cells thus far

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78500506084be802221455df98ccf976
https://doi.org/10.1172/jci119396

Analysis of CD27 surface expression on T cell subsets in MS patients and control individuals

Autor: R. Q. Hintzen, R. A. W. Van Lier, Chris H. Polman, Hans Link, U. Fiszer, M.H.G. Rep, Sten Fredrikson

Publikováno v: Journal of neuroimmunology, 56(1), 99-105. Elsevier

Within the peripheral blood, CD4+CD27- T cells only reside within the CD45RA- (memory or primed) T cell subset. Cells with this phenotype have characteristics of specialized effector T cells according to their cytokine secretion profiles and the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72df27fc26be49b1d2245aa5a93d813
https://doi.org/10.1016/0165-5728(94)00137-d

Functional Capacities of High Endothelial Venules Appear not to be Controlled by Recirculating Lymphocytes

Autor: Adrian M. Duijvestijn, Hans R. Hendriks, Georg Kraal, M.H.G. Rep

Publikováno v: Immunobiology. 180:295-307

The influence of recirculating lymphocytes on the function and morphology of high endothelial venules (HEV) has been studied. Mice were depleted of lymphocytes by lethal (1200 cGy) total body irradiation; subsequently, the HEV in mesenteric and cervi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0387a7ad779f9e8f3e33b1d4d3899ea
https://doi.org/10.1016/s0171-2985(11)80293-7

Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells

Autor: Frederik Barkhof, Chris H. Polman, R. A. W. Van Lier, H.J. Adèr, Joep Killestein, M.H.G. Rep, Marijke T. L. Roos

Publikováno v: Journal of neuroimmunology, 118(2), 286-294. Elsevier

Background : The role of T cell subpopulations and their ability to produce immunoregulatory cytokines has been extensively studied in multiple sclerosis (MS). However, the exact mechanisms by which T cells and cytokines contribute to disease activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e50f0b70506706e894400b36b31fe99
https://pubmed.ncbi.nlm.nih.gov/11498263