Zobrazeno 1 - 10 of 22 pro vyhledávání: '"M.H. le Du"'
1
Artificial Evolution of an Enzyme Active Site: Structural Studies of Three Highly Active Mutants of Escherichia coli Alkaline Phosphatase
Autor: André Ménez, O.V. Bulgakov, M.H. Le Du, J.-C. Boulain, E. Lajeunesse, Bruno H. Muller, C. Lamoure
Publikováno v: Journal of Molecular Biology. 316:941-953
The crystal structure of three mutants of Escherichia coli alkaline phosphatase with catalytic activity (k(cat)) enhancement as compare to the wild-type enzyme is described in different states. The biological aspects of this study have been reported
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae68457df83e578959a6706e3b467c0d
https://doi.org/10.1006/jmbi.2001.5384
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2
Highly specific anti-estradiol antibodies: structural characterisation and binding diversity 1 1Edited by I. A. Wilson
Autor: André Ménez, Enrico A. Stura, Bernard Gilquin, Florence Bettsworth, Geneviève Sibaï, M.H. Le Du, Céline Monnet, Sophie Zinn-Justin, Michel Jolivet, R. Menez, Nicole Battail-Poirot, Jean-Baptiste Charbonnier, Frédéric Ducancel, Michel Arnaud, L. Derrien
Publikováno v: Journal of Molecular Biology. 315:699-712
Subtle modulation of antibody-binding properties by protein engineering often lies with an accurate structural and energetic description of how an antigen is recognised. Thus, with the intent to increase the affinity and add a bias in favour of natur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e41666c62afb1668718c92f0ae2ac8d
https://doi.org/10.1006/jmbi.2001.5284
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3
Stability of a structural scaffold upon activity transfer: X-ray structure of a three fingers chimeric protein 1 1Edited by R. Huber
Autor: Renée Ménez, M.H. Le Du, J.-C. Boulain, M. Khayati, André Ménez, A. Ricciardi, Frédéric Ducancel
Publikováno v: Journal of Molecular Biology. 296:1017-1026
Fasciculin 2 and toxin alpha proteins belong to the same structural family of three-fingered snake toxins. They act on different targets, but in each case the binding region involves residues from loops I and II. The superimposition of the two struct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15e4aee65af18214d53db6d5d63df669
https://doi.org/10.1006/jmbi.2000.3510
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5
Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers
Autor: M. Lefranc, Michel Masella, J.-C. Boulain, M.H. Le Du, L. Pardo, Enrico A. Stura, Jean-Baptiste Charbonnier, Philippe Cuniasse, Gilles Mourier, Alain Lecoq, and A. Menez, D. Gasparini, A. Joly, A. Caruana, C. Magis
Publikováno v: Journal of the American Chemical Society. 128(50)
We have developed a structure-based approach to the design of protein ligands. This approach is based on the transfer of a functional binding motif of amino acids, often referred as to the "hot spot", on a host protein able to reproduce the functiona
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf9eeb4620cc292313c9a9c22b453bd
https://pubmed.ncbi.nlm.nih.gov/17165772
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6
Molecular Evolution of Snake Toxins: Is the Functional Diversify of Snake Toxins Associated with a Mechanism of Accelerated Evolution?
Autor: J.-C. Boulain, M.H. Le Du, C. Fromen, Frédéric Ducancel, Sophie Zinn-Justin, T. Tamiya, Tomohisa Ogawa, Motonori Ohno, J.M. Danse, Renée Ménez, André Ménez, Yasuyuki Shimohigashi
Publikováno v: Progress in Nucleic Acid Research and Molecular Biology ISBN: 9780125400596
Recent studies revealed that animal toxins with unrelated biological Functions often possess a similar architecture. To tentatively understand the evolutionary mechanisms that may govern this principle of functional prodigality associated with a stru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aea59891a5c9c28d0677da8a762bb4d
https://doi.org/10.1016/s0079-6603(08)61036-3
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8
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9
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10
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