Zobrazeno 1 - 10
of 91
pro vyhledávání: '"M.G.R. Rajan"'
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 314:483-490
O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N′-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step process starting from RS-tyrosine,
Autor:
Mariam S. Degani, N. Lakshminarayanan, Surendra H. Moghe, Yogita Pawar, M.G.R. Rajan, Arun M. Bhusari
Publikováno v:
Radiochimica Acta. 105:721-728
Recently we developed [18F] 4-(2-fluoroethoxy)-2H-chromen-2-one as a novel 18F myocardial perfusion imaging radiotracer. It was synthesized in good radiochemical yield (>90%). The total time from radiosynthesis to its purification was less than 40 mi
Autor:
M.G.R. Rajan, Arpit Mitra, Tapas Das, Haladhar Dev Sarma, Sangita Lad, Ajit Sugunan Shinto, Koramadai Karuppuswamy Kamaleshwaran, Sharmila Banerjee, Sahiralam Khan Mohammed
Publikováno v:
Applied Radiation and Isotopes. 122:7-13
The objective of the present work is to formulate 170Tm-EDTMP using an in-house freeze-dried EDTMP kit and evaluate its potential as a bone pain palliation agent. Patient dose of 170Tm-EDTMP was prepared with high radiochemical purity using the lyoph
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 310:991-999
[18F]FET was synthesized using O-(2′-tosyloxyethyl)-N-trityl-l-tyrosine-tert-butyl ester (TET) precursor. SPE purification of [18F]FET, after radio-synthesis, using neutral alumina column was satisfactory, with radiochemical and enantiomeric purity
Autor:
Aarti Anantram, M.K. Ray, Madhav Seervi, Archana Raju, Sadhana Sathaye, Mariam S. Degani, Puneet P. Jain, M.G.R. Rajan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:645-649
A series of novel quinoline-oxadiazole hybrid compounds was designed based on stepwise rational modification of the lead molecules reported previously, in order to enhance bioactivity and improve druglikeness. The hybrid compounds synthesized were sc
Publikováno v:
Phytotherapy Research. 29:1646-1651
With the view of exploring phytochemicals as Mycobacterium tuberculosis (Mtb) dihydrofolate reductase inhibitors, known plant polyphenols from various classes were subjected to detailed docking studies. From this in-silico screening, seven polyphenol
Autor:
Bharat Ratna Sarkar, Madhusmita, Umesh Kumar, M.K. Das, Shantanu Ganguly, Samarendu Sinha, Kakali De, Luna Barua, Md. Alam Nayer, Anirban De, M.G.R. Rajan, Tapas Mallick, Sankha Chattopadhyay, Arpit Mitra, Sujata Saha Das
Publikováno v:
Journal of Radioanalytical and Nuclear Chemistry. 302:781-790
Performance study of a computer controlled automated closed cyclic module for the separation and recovery of 99mTc from low specific activity (n, γ) 99Mo using methyl ethyl ketone (MEK) solvent extraction technique named 99Mo/99mTc-TCM-AUTOSOLEX (Te
Publikováno v:
Current Research in Drug Discovery. 1:45-50
A series of novel 2,4 diamino-s-triazine was designed as potential Mycobacterium tuberculosis (Mtb) Dihydro folate reductase inhibitors. The synthesized compounds were evaluated in whole cells by employing Resazurin Microtitre Plate Assay (REMA) agai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6097-6105
A series of novel arylquinoline derivatives was designed retaining significant pharmacophoric features and three dimensional geometry of bedaquiline. In silico ADME study was performed to assess drug likeness and toxicity profiles of the designed mol
Publikováno v:
Clinical Nutrition. 31:749-755
summary Background & aims: Diabetes causes impairment of various enzyme activities in the physiological system, including lysosomal enzymes. The effect of feeding curcumin, quercetin and aminoguanidine on lysosomal enzyme activities viz., N-acetyl-b-