Stereolability of Dihydroartemisinin, an Antimalarial Drug: A Comprehensive Kinetic Investigation. Part 2

Autor: Francesco Gasparrini, Patrizia Simone, M.G. Quaglia, Fabrizio Giorgi, Marta Di Iorio, Andrea Mazzanti, Ilaria D'Acquarica, Walter Cabri, Marco Pierini, Michela Di Mattia, Claudio Villani

Publikováno v: The Journal of Organic Chemistry. 76:4831-4840

Artemisinin or qinghaosu has now largely given way to the more potent dihydroartemisinin (DHA, 1) and its derivatives in the treatment of drug-resistant malaria, in combination with other classical antimalarial drugs. DHA is obtained by NaBH(4) reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58336e0e43695a135a13bea99d2f2ea7
https://doi.org/10.1021/jo102392p

Micellar electrokinetic chromatography for determination of drug partition in phospholipids

Autor: Salvatore Fanali, Francesco Barbato, M.G. Quaglia, Enrica Donati

Publikováno v: Il Farmaco (Pavia) 60 (2005): 77.
info:cnr-pdr/source/autori:M. G. Quaglia, S. Fanali, F. Barbato, E. Donati/titolo:Micellar electrokinetic chromatography for determination of drug partition in phospholipids/doi:/rivista:Il Farmaco (Pavia)/anno:2005/pagina_da:77/pagina_a:/intervallo_pagine:77/volume:60

The lipophilicity of pipemidic, nalidixic and oxolinic acids was determined by forming phospholipidic micelles directly in an electrophoretic capillary. Phosphatidylcholine derivatives, namely l -α-dilauroyl phosphatidylcholine (DLPC) or l -α-dimir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e9c6795cf9ffafc7e0228d19310919
https://doi.org/10.1016/j.farmac.2004.10.003

Chiral investigation of midodrine, a long-acting α-adrenergic stimulating agent

Autor: Nicoletta Desideri, A. Farina, Elena Bossù, M. Palmery, Sabrina Strano, M.G. Quaglia, Enrica Donati

Publikováno v: Chirality. 16:356-362

Midodrine hydrochloride is a peripheral α1-adrenoreceptor agonist that induces venous and arterial vasoconstriction. Midodrine, after oral or intravenous administration, undergoes enzymatic hydrolysis and releases deglymidodrine, a pharmacologically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::190a1f671fab1f9c3b010162bc00fe02
https://doi.org/10.1002/chir.20041

Chiral resolution and molecular modeling investigation ofrac-2-cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047), a potent anti-HIV-1 reverse transcriptase agent of the DABO class

Autor: Silvio Massa, Silvia Doratiotto, Marco Artico, Rino Ragno, M.G. Quaglia, Gianluca Sbardella, Antonello Mai, D. del Piano, G. Setzu, V. Cotichini

Publikováno v: Chirality. 13:75-80

rac-2-Cyclopentylthio-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methylpyrimidin-4(3H)-one (MC-1047) is a potent inhibitor of HIV-1 multiplication in acutely infected cells. MC-1047 racemate has been resolved by chiral HPLC using, as chiral statio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bd2577347d235c9fd9f439c5e50a1ca
https://doi.org/10.1002/1520-636x(2001)13:2<75::aid-chir1001>3.0.co

Use of nano-liquid chromatography for the analysis of glycyrrhizin and glycyrrhetic acid in licorice roots and candies

Autor: Maria Augusta Raggi, Salvatore Fanali, Zeineb Aturki, Giovanni D'Orazio, M.G. Quaglia, Cesare Sabbioni, Anna Rocco

Publikováno v: Journal of separation science
28 (2005): 982–986. doi:10.1002/jssc.200400096
info:cnr-pdr/source/autori:Fanali, S; Aturki, Z; D'Orazio, G; Raggi, MA; Quaglia, MG; Sabbioni, C; Rocco, A/titolo:Use of nano-liquid chromatography for the analysis of glycyrrhizin and glycyrrhetic acid in licorice roots and candies/doi:10.1002%2Fjssc.200400096/rivista:Journal of separation science (Print)/anno:2005/pagina_da:982/pagina_a:986/intervallo_pagine:982–986/volume:28
28 (2005): 982.
info:cnr-pdr/source/autori:S. Fanali, Z. Aturki, G. D’Orazio, M. A. Raggi, M. G. Quaglia, C. Sabbioni, A. Rocco/titolo:Use of nano-liquid chromatography for the analysis of glycyrrhizin and glycyrrhetic acid in licorice roots and candies/doi:/rivista:/anno:2005/pagina_da:982/pagina_a:/intervallo_pagine:982/volume:28

Glycyrrhizin (G) and glycyrrhetic acid (GA) were separated by using nano-liquid chromatography(nano-LC) in a fused silica capillary packed with RP18 stationary phase (75 micron ID, effective length 33 cm, packed 23 cm) eluting at 300 nL/min in a grad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809a7d5ac625f1dd1edd677a0a46d747
https://pubmed.ncbi.nlm.nih.gov/16013825