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Akademický článek

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action.

Autor: S Haubenwallner, A.D. Essenburg, B.C. Barnett, M.E. Pape, R.B. DeMattos, B.R. Krause, L.L. Minton, B.J. Auerbach, R.S. Newton, T Leff

Publikováno v: Journal of Lipid Research, Vol 36, Iss 12, Pp 2541-2551 (1995)

For the last 30 years fibrates have been widely prescribed to treat human dyslipidemia. However, the primary mechanism by which they lower plasma lipid levels is still unknown. Studies with transgenic mice have suggested that changes in apoC-III expr

Externí odkaz: https://doaj.org/article/75e65e3c572e472f94a094b8ceb50863

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Molecular cloning, sequence, and expression of cynomolgus monkey cholesteryl ester transfer protein. Inverse correlation between hepatic cholesteryl ester transfer protein mRNA levels and plasma high density lipoprotein levels

Autor: Keith R. Marotti, E F Rehberg, George W. Melchior, M.E. Pape

Publikováno v: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 11:1759-1771

A cDNA clone containing the coding region for cynomolgus monkey cholesteryl ester transfer protein (CETP) was isolated by the polymerase chain reaction with primers based on the human CETP cDNA sequence and cDNA synthesized from liver poly (A+) RNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d832d9e4f00aa741ed2195be89c441c
https://doi.org/10.1161/01.atv.11.6.1759

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Secretion of pre-beta-migrating apoA-I by cynomolgus monkey hepatocytes in culture

Autor: George W. Melchior, M.E. Pape, Keith R. Marotti, Christine K. Castle

Publikováno v: Journal of Lipid Research, Vol 32, Iss 3, Pp 439-447 (1991)

Cynomolgus monkey hepatocytes that had been stored frozen were thawed, established in culture, and used to study apoA-I secretion. Protein synthetic activity was low at first, but increased with time, approaching what appeared to be the constitutive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9fa4c6fad71d88378a3f71924713cf
https://doi.org/10.1016/s0022-2275(20)42067-x

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An improved method for precise quantitation of cellular and tissue apolipoprotein A-I mRNA levels by use of an internal standard

Autor: M.E. Pape, Keith R. Marotti, George W. Melchior

Publikováno v: Journal of Lipid Research, Vol 31, Iss 4, Pp 727-733 (1990)

We have developed a method for the quantitation of apolipoprotein A-I (apoA-I) mRNA by using a variation of traditional S1 nuclease analysis. This method uses an internal standard RNA that allows a level of precision not obtainable with traditional S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdee8b741bf7ece2885511a7fffed8ff
https://doi.org/10.1016/s0022-2275(20)42842-1

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Evidence that the nonparenchymal cells of the liver are the principal source of cholesteryl ester transfer protein in primates

Autor: Keith R. Marotti, George W. Melchior, R.G. Ulrich, T.J. Rea, M.E. Pape

Publikováno v: Journal of Biological Chemistry. 266:12829-12831

Previous studies showed that 90% or more of the cholesteryl ester transfer protein (CETP) mRNA is contained in the liver of cynomolgus monkeys. The purpose of this study was to determine if the parenchymal cells (hepatocytes) were the hepatic cell ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aced4302a240c63242e3c14ffc2851ff
https://doi.org/10.1016/s0021-9258(18)98766-1

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Apo B metabolism in the cynomolgus monkey: evidence for post-transcriptional regulation

Autor: George W. Melchior, G.M. Funk, C.E. Hunt, R.W. Murray, M.E. Pape, Keith R. Marotti, Christine K. Castle

Publikováno v: Biochimica et biophysica acta. 1086(3)

Previous studies have shown that hepatic apo B mRNA levels do not increase in animals fed high cholesterol diets, even though plasma apo B concentrations increase markedly. As a result, it has been suggested that the diet-induced increase in plasma a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee18b250d9a6157870e2f1339569878f
https://pubmed.ncbi.nlm.nih.gov/1742325

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mRNA quantitation by a simple and sensitive RNAse protection assay

Autor: George W. Melchor, Keith R. Marotti, M.E. Pape

Publikováno v: Genetic analysis, techniques and applications. 8(7)

An RNAse protection assay is described that increases substantially the degree of precision with which one can measure the mRNA levels in cells and tissues through the use of the internal standard. The assay can be used to measure any mRNA for which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9687fb176eb752b02bbf6e9f40b55571
https://pubmed.ncbi.nlm.nih.gov/1772697

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