Comparative efficacy of PD-1 blockade in patients with dMMR/MSI-H metastatic colorectal or gastric cancer: a global retrospective study

Autor: G. Mazzoli, F. Nichetti, K. Shitara, R. Cohen, S. Lonardi, C. Cremolini, M.E. Elez, J. Chao, M. Fakih, S.J. Klempner, P. Jayachandran, S. Maron, D. Cowzer, L. Fornaro, L. Salvatore, V. Zhu, Y. Aoki, R. Cerantola, F. Bergamo, M. Salati, M. Ambrosini, G. Sabella, G. Randon, M.J. Overman, T. André, F. Pietrantonio

Publikováno v: ESMO Gastrointestinal Oncology, Vol 3, Iss , Pp 100037- (2024)

Background: Programmed cell death protein 1 (PD-1) blockade improved the survival of patients with mismatch repair deficient (dMMR) and/or microsatellite instability-high (MSI-H) tumors, leading to tumor-agnostic approval of pembrolizumab in this pop

Externí odkaz: https://doaj.org/article/0c37cc0360804ca5b240475f9112cdce

526P Efficacy and safety of fruquintinib in refractory metastatic colorectal cancer: A FRESCO-2 subgroup analysis by age.

Autor: Fernandez, M.E. Elez¹ (AUTHOR), Dasari, N.A.² (AUTHOR), Lonardi, S.³ (AUTHOR), Eng, C.⁴ (AUTHOR), Garcia-Carbonero, R.⁵ (AUTHOR), Yoshino, T.⁶ (AUTHOR), Sobrero, A.⁷ (AUTHOR), Yao, J.C.² (AUTHOR), Alfonso, P. García⁸ (AUTHOR), Kocsis, J.⁹ (AUTHOR), Gracian, A. Cubillo¹⁰ (AUTHOR), Bianchi, A. Sartore¹¹ (AUTHOR), Satoh, T.¹² (AUTHOR), Randrian, V.¹³ (AUTHOR), Cremolini, C.¹⁴ (AUTHOR), Yang, Z.¹⁵ (AUTHOR), Schelman, W.¹⁵ (AUTHOR), Zhu, H.¹⁶ (AUTHOR), Chen, L.¹⁶ (AUTHOR), Tabernero, J.¹ (AUTHOR)

Publikováno v: Annals of Oncology. 2024 Supplement 2, Vol. 35, pS442-S443. 2p.

588P Genomic landscape of acquired resistance to first-line (1L) anti-EGFR treatment in metastatic colorectal cancer (mCRC) beyond the classical EGFR pathway: Findings from the PLATFORM-B study

Autor: Martelli, V., Barrull, J. Vidal, Rodriguez, C. Fernandez, Toledo, R.D.A., Gibert, J., Alfonso, P. García, Paez, D., Alonso-Orduna, V., Gomez España, M.A., Vivas, C. Santos, Ogaya, G. Duran, Fernandez, M.E. Elez, Garcia-Carbonero, R., Monteagudo, R. Ferreiro, Mozo, J.L. Manzano, Paricio, B. Bellosillo, Tabernero, J., Soler, R. Salazar, Aguilar, E. Aranda, Viladot, C. Montagut

Publikováno v: In Annals of Oncology September 2024 35 Supplement 2:S474-S475

561P Liquid biopsy tracking of immunotherapy-induced T cell dynamics in MSS colorectal and endometrial tumors

Autor: Heyn, H., Melero, J.L., Deuner, G., Argota, I. Baraibar, Grzelak, M., Caratu, G., Duran, C. Garcia, Béjar, J.F. Grau, Illescas, D.G., Madrid, L. Fariñas, Nieto, P., Morabito, S., Rotem, A., Casbas-Hernandez, P., Gros, A., Tabernero, J., Oaknin, A., Sachica, J.N., Borcherding, N., Fernandez, M.E. Elez

Publikováno v: In Annals of Oncology September 2024 35 Supplement 2:S460-S461

540P Early treatment discontinuation (ETD) in dMMR/MSI-H metastastic colorectal cancer (mCRC) treated with immune checkpoint inhibitors (ICIs)

Autor: Taieb, J., Ambrosini, M., Alouani, E.L., Lonardi, S., Sinicrope, F.A., Decraecker, M., Hollebecque, A., Hafliger, E., Mazard, T., Pernot, S., Parent, P., Fernandez, M.E. Elez, Overman, M.J., Jayachandran, P., Nasca, V., Salvatore, L., Guimbaud, R., Cremolini, C., Tougeron, D., Pietrantonio, F.

Publikováno v: In Annals of Oncology September 2024 35 Supplement 2:S450-S451