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Publikováno v:
Bone. 67
The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demon
Autor:
Robert Zamboni, Jocelyne Guay, Stella Charleson, M.D. Percival, Jean-Pierre Falgueyret, Joseph A. Mancini, Susan Boyce, Michael J. Therien, Lijing Xu, R. Gordon, Stacia Kargman, Anthony W. Ford-Hutchinson, Gillian Greig, Marc Ouellet, Denis Riendeau, Petpiboon Prasit, Serge Leger, Zhaoyin Wang, J.K. Webb, Diane Ethier, Chi-Chung Chan, Gary P. O'Neill, Robert N. Young, Ian W. Rodger, Wanda Cromlish, Christine Brideau, Jillian F. Evans, Michael J. Gresser, E. Wong
Publikováno v:
British Journal of Pharmacology. 121:105-117
1. DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furan one) was identified as a novel orally active and highly selective cyclo-oxygenase-2 (COX-2) inhibitor. 2. In CHO cells stably transfected with human COX isozymes, DFU inh
Publikováno v:
Protein Expression and Purification. 9:388-398
Human cyclooxygenase-2 (hCox-2) is a key enzyme in the biosynthesis of prostaglandins and the target of nonsteroidal anti-inflammatory drugs. Recombinant hCox-2 overexpressed in a vaccinia virus (VV)-COS-7 system comprises two glycoforms. Removal of
Autor:
M.D. Percival, Patrick Garnero, Jean-Marie Delaissé, Anne-Christine Bay-Jensen, N. Charni-Ben Tabassi, S. Desmarais
Publikováno v:
Charni-Ben Tabassi, N, Desmarais, S, Jensen, A-C B, Delaissé, J M, Percival, M D & Garnero, P 2008, ' The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation ', Osteoarthritis and Cartilage . https://doi.org/10.1016/j.joca.2008.02.008
Udgivelsesdato: Apr-8 OBJECTIVE: Cartilage degradation in osteoarthritis (OA) generates the type II collagen fragments, Helix-II and CTX-II that can be used as clinical biological markers. Helix-II and C-telopeptide of type II collagen (CTX-II) level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd574de379d33f20f8f844f13f0a0b10
https://portal.findresearcher.sdu.dk/da/publications/144fa310-4bff-11dd-b1a1-000ea68e967b
https://portal.findresearcher.sdu.dk/da/publications/144fa310-4bff-11dd-b1a1-000ea68e967b
Publikováno v:
Biochemistry. 38(41)
The cysteine protease cathepsin K is believed to play a key role in bone resorption as it has collagenolytic activity and is expressed predominantly and in high levels in bone resorbing osteoclast cells. The addition of nitric oxide (NO) and NO donor
Autor:
D Patrick, Denis Riendeau, Michael J. Therien, E. Wong, Zhaoyin Wang, Nadia M.J. Rupniak, Robert N. Young, Wanda Cromlish, Christine Brideau, Michael J. Forrest, Diane Ethier, Helene Perrier, Yves Leblanc, Chi-Chung Chan, Susan Boyce, Stella Charleson, Lijing Xu, R. Gordon, Joseph A. Mancini, Jacques-Yves Gauthier, Ian W. Rodger, Brian P. Kennedy, Stacia Kargman, Marc Ouellet, Philip J. Vickers, Denise M. Visco, Anthony W. Ford-Hutchinson, Robert Zamboni, Michael J. Gresser, Jocelyne Guay, Petpiboon Prasit, M.D. Percival, Philip Tagari, Serge Leger, Jillian F. Evans, Gary P. O'Neill
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(13)
The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described. It is essentially equipotent to indomethacin both in vitro and in vivo but without the ulcerogenic side effect due to COX-1 inhibition.
Autor:
M.D. Percival, V Houtzager, Jean-Pierre Falgueyret, Lori A. Passmore, Christopher I. Bayly, Marc Ouellet
Publikováno v:
Biochemistry. 35(33)
The steady state tryptophan fluorescence of apo-human cyclooxygenase-2 (hCox-2) is quenched approximately 40%-50% by the slow binding inhibitors diclofenac, indomethacin, ketoprofen, NS-398, and DuP-697. The effects of these inhibitors on tryptophan
Publikováno v:
Archives of biochemistry and biophysics. 315(1)
Recombinant human cyclooxygenase-2 (hCox-2, Prostaglandin G/H synthase-2) has been purified from baculovirus-Sf9 and vaccina virus-Cos-7 cell expression systems. The detergent-solubilized, purified enzyme is heterogeneous in terms of its glycosylatio
Publikováno v:
Archives of biochemistry and biophysics. 314(1)
Active human cyclooxygenase-2 (Cox-2) was expressed at high levels in insect cells using a recombinant baculovirus. The specific activity of Cox-2 in the microsomes of infected cells was 0.51 mumol O2/min/mg and was comparable to that obtained for pa