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pro vyhledávání: '"M.Cecilia Aguila"'
Publikováno v:
Brain Research. 842:351-358
Ataxia-telangiectasia (A-T) is a human disorder with pleiotropic manifestations that include neoplasms, immune dysfunction and neurodegeneration. The disorder is due to mutations in the gene known as ATM (A-T, mutated), which causes a deficiency in i
Autor:
M.Cecilia Aguila
Publikováno v:
Peptides. 19:1573-1579
Growth hormone (GH) secretion from the pituitary is known to be under the dual control of GH-releasing factor (GRF) and somatostatin (SRIF). Hypothalamic SRIF, the major inhibitor of pituitary growth hormone secretion, inhibits its own release by a n
Autor:
Rodrigo O. Kuljis, M.Cecilia Aguila
Publikováno v:
Brain research. 816(1)
Nitric oxide (NO) synthase (NOS)-containing cerebrocortical neurons degenerate in patients with amyotrophic lateral sclerosis (ALS) and dementia, and in transgenic mice expressing a mutated superoxide dismutase gene (G93A) associated with familial AL
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(23)
Neural degeneration is one of the clinical manifestations of ataxia–telangiectasia, a disorder caused by mutations in the Atm protein kinase gene. However, neural degeneration was not detected with general purpose light microscopic methods in previ