How a low-fidelity DNA polymerase chooses non-watson-crick from watson-crick incorporation

Autor: Frank H. T. Nelissen, J.L. Wu, M.I. Su, M.C.C. Chen, J.F. Doreleijers, Tsai, Sybren S. Wijmenga, Sandeep Kumar, L.H. Lim, Chung-Feng Wang, Wen-Jin Wu

Publikováno v: Journal of the American Chemical Society, 136, 13, pp. 4927-4937
Journal of the American Chemical Society, 136, 4927-4937

A dogma for DNA polymerase catalysis is that the enzyme binds DNA first, followed by MgdNTP. This mechanism contributes to the selection of correct dNTP by Watson-Crick base pairing, but it cannot explain how low-fidelity DNA polymerases overcome Wat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4e3161301d9d7a4fa725b172f86108
https://hdl.handle.net/2066/128384