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A yeast-based system to study SARS-CoV-2 M(pro) structure and to identify nirmatrelvir resistant mutations

Autor: Jin Ou, Eric M. Lewandowski, Yanmei Hu, Austin A. Lipinski, Ryan T. Morgan, Lian M.C. Jacobs, Xiujun Zhang, Melissa J. Bikowitz, Paul Langlais, Haozhou Tan, Jun Wang, Yu Chen, John S. Choy

Publikováno v: bioRxiv

The SARS-CoV-2 main protease (Mpro) is a major therapeutic target. The Mpro inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As Mpro inhibitor use increases, drug resistant mutations will li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f7ee0ec99dd96aecdc82a3a6f3de26
https://europepmc.org/articles/PMC9387140/

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Structural Insights into Molecular Recognition by Human Chemokine CCL19

Autor: Eric M. Lewandowski, Kyle G. Kroeck, Lian M.C. Jacobs, Tyler G. Fenske, Robin N. Witt, Alyssa M. Hintz, Elizabeth R. Ramsden, Xiujun Zhang, Francis Peterson, Brian F. Volkman, Christopher T. Veldkamp, Yu Chen

Publikováno v: Biochemistry

The human chemokines CCL19 and CCL21 bind to the G-protein coupled receptor (GPCR) CCR7 and play an important role in the trafficking of immune cells, as well as cancer metastasis. Conserved binding sites for sulfotyrosine residues on the receptor co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f708794d43a7b1b708cbed603e4d6421
https://europepmc.org/articles/PMC9254573/

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ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin-6

Autor: Loes H. Willems, Magdolna Nagy, Hugo Ten Cate, Henri M.H. Spronk, Lotte M.C. Jacobs, Josephine Kranendonk, Maaike van Leeuwen, Danielle Meijer, Saskia Middeldorp, Laszlo A. Groh, Michiel C. Warlé

Publikováno v: Research and practice in thrombosis and haemostasis, 5(8):e12630. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis, 5, 8
Research and practice in thrombosis and haemostasis, 5(8):e12630. Wiley
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 8, Pp n/a-n/a (2021)
Research and Practice in Thrombosis and Haemostasis, 5
Research and Practice in Thrombosis and Haemostasis

Contains fulltext : 245424.pdf (Publisher’s version ) (Open Access) BACKGROUND: Vaccination is the leading approach in combatting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. ChAdOx1 nCoV-19 vaccination (ChAdOx1) has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158e9331c3f59994c2263bf9b62ff1fc
https://pure.amc.nl/en/publications/chadox1-vaccination-blood-coagulation-and-inflammation(9cea31fd-73d9-44a7-ade2-7f466f43a9c0).html

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Embryotoxicity of human sera from patients treated with isotretinoin

Autor: M.C. Jacobs, P. Berthet, G. Gofflot, P. Therasse, J.J. Picard, G. Van Maele-Fabry, K. Despontin, J.P. Desager, Jean-Marie Lachapelle, C. Lecart, E. Lenoir

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 7(6)

Sera of 20 patients treated with 20-40 mg isotretinoin/day were tested for embryotoxicity potential. For each patient, the first sample was taken before treatment (control sample) and the second was taken 2 months after the start of treatment (treate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b02a3dbc6a473bab9b3ebce808f8a6e
https://pubmed.ncbi.nlm.nih.gov/20732284

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Catecholamines and Neurocarondiogenic Syncope

Autor: Th. Thien, J.W.M. Lenders, M.C. Jacobs, David S. Goldstein

Publisher Summary The combination of enhanced adrenomedullary and attenuated sympathoneural responses during slight reductions in cardiac filling antecede the syncope. The findings are consistent with the view that sudden, central resetting of barore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03587cf72b4e868dc37a8725197ee9ee
https://doi.org/10.1016/s1054-3589(08)60824-8

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Akademický článek

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Akademický článek

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