Zobrazeno 1 - 10
of 78
pro vyhledávání: '"M.C. Garel"'
Autor:
Juliette Smith-Ravin, M.C. Garel, Paul-Henri Romeo, Frédéric Galactéros, Dora Bachir, Christelle M. Rodrigue, Nicole Arous
Publikováno v:
British Journal of Haematology. 113:500-507
Resveratrol, a natural dietary polyphenol, has been postulated to be implicated in the cardioprotective effect of red wine and the low incidence of breast and prostate cancers among vegetarians and Orientals respectively. This compound inhibits ribon
Publikováno v:
Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie. 320:27-33
In red blood cells, a modulation of the level of the allosteric effector of hemoglobin, 2,3-diphosphoglycerate (2,3-DPG) would have implications in the treatment of ischemia and sickle cell anemia. Its concentration is determined by the relative acti
Autor:
Constantin T. Craescu, M.C. Garel, Marie-Claude Calvin, Jean Rosa, Raymonde Rosa, Nicole Arous
Publikováno v:
Proceedings of the National Academy of Sciences. 91:3593-3597
To date no definite and undisputed treatment has been found for sickle cell anemia, which is characterized by polymerization of a deoxygenated hemoglobin mutant (HbS) giving rise to deformed erythrocytes and vasoocclusive complications. Since the ery
Publikováno v:
Biochimie, Vol. 74, No 6 (1992) pp. 519-526
Using the crystallographic structure of yeast monophosphoglycerate mutase (MPGM) as a framework we constructed a three-dimensional model of the homologous human erythrocyte bisphosphoglycerate mutase (BPGM). The modeling procedure consisted of substi
Autor:
Dora Bachir, Yves Beuzard, Frédéric Galactéros, Mark D. Scott, Philippe Rouyer-Fessard, M.C. Garel, K Leroy-Viard
Publikováno v:
Annals of the New York Academy of Sciences. 612:106-117
The fate of alpha-hemoglobin chains and the cause of membrane protein defects in thalassemic erythrocytes have been studied in: (1) human beta-thalassemia syndromes, (2) mouse beta-thalassemia, and (3) normal human erythrocytes loaded with purified a
Autor:
Raymonde Rosa, Yves Blouquit, M.C. Garel, Michel Cohen-Solal, Philippe Leboulch, Judit Castella-Escola, Colette Valentin, Fernando Climent-Romeo, David M. Ojcius, Virginie Joulin
Publikováno v:
Gene. 91:225-232
The human muscle-specific phosphoglycerate mutase encoding gene (PGAM-M) has been cloned from a genomic cosmid library and sequenced. The sequence corresponding to the coding region was evaluated and revised by sequencing of the protein itself, fully
Autor:
Yves Blouquit, M.C. Garel, Michel Cohen-Solal, Marie-Claude Calvin, Marie-Odette Prehu, Raymonde Rosa, Jean-Philippe Rosa
Publikováno v:
Biochimie. 72:337-343
Bisphosphoglycerate mutase (EC 5.4.2.4.) is an erythrocyte-specific enzyme whose main function is to synthesize 2,3-diphosphoglycerate (glycerate-2,3-P2) an effector of the delivery of O2 in the tissues. In addition to its main synthase activity the
Publikováno v:
International journal of biological macromolecules. 15(4)
The reactivities of disulfides of different compound families towards thiol groups of human haemoglobin and human serum albumin were determined at physiological pH 7.4 by anion-exchange liquid chromatography. The apparent second-order kinetic rate co
Autor:
Raymonde Rosa, Nicole Arous, Valérie Lemarchandel, Marie-Claude Calvin, M.C. Garel, Constantin T. Craescu, Jean Rosa, Marie-Odette Prehu
Publikováno v:
European journal of biochemistry. 213(1)
Human bisphosphoglycerate mutase (GriP2 mutase) is a trifunctional enzyme which synthesizes and degrades GriP2 in red cells. Among the amino acid residues involved in its active site there are two conserved histidine residues, His10 which is phosphor
Autor:
J L Guerquin-Kern, M.C. Garel, N Saadane, J Bardakdjian-Michau, A Pachnis, Paul-Henri Romeo, Y Blouquit, P Rouyer-Fessard, M Trudel, D Vidaud
Publikováno v:
The EMBO journal. 10(11)
In order to obtain a transgenic mouse model of sickle cell disease, we have synthesized a novel human beta-globin gene, beta SAD, designed to increase the polymerization of the transgenic human hemoglobin S (Hb S) in vivo. beta SAD (beta S-Antilles-D