Zobrazeno 1 - 10
of 84
pro vyhledávání: '"M.A.W. Eaton"'
Autor:
Richard J. K. Taylor, John Clifford Head, James Thomas Reuberson, Brian Hutchinson, P. Turner, E.C. Boyd, M.A.W. Eaton, B. Hughes, G. Higgs, John Robert Porter, Alex Zomaya, Neil Gozzard, R.A. Allen, Rikki Peter Alexander, Andrew T. Millican, M. Wales, R. Morphy, Joanna Leonard, A. Cannell, Julien Alistair Brown, Martin J. Perry, Byron A. Boyce, Barbara Mason, D. Barnes, Graham John Warrellow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1451-1456
The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), a potent, chiral, selective inhibitor of PDE 4 (IC(50) 4
Publikováno v:
Nucleic Acids Research. 11:7427-7434
cDNA clones coding for the A alpha- and gamma-chains of human fibrinogen have been isolated from an adult liver cDNA library. Clones were identified by hybridisation with mixtures of synthetic oligonucleotides 17 bases long, predicted using amino aci
Autor:
T.P. Patel, Paul G. Thomas, C.C. Bose, T.J.R. Harris, Norman Henry Carey, M.A.W. Eaton, A. Lyons, T.A. Millican, Michael Terence Doel, P.A. Lowe
Publikováno v:
Nucleic Acids Research. 10:2177-2187
DNA complementary to calf stomach mRNA has been synthesised and inserted into the Pst1 site of pAT153 by G-C tailing. Clones containing sequences coding for prochymosin were recognised by colony hybridisation with cDNA extended from a chemically synt
Publikováno v:
Nucleic Acids Research. 12:6853-6859
An equimolar solution of aldoxime and tetramethylguanidine at 70 degrees C removes both the base and phosphate protection from oligonucleotides prepared by solid phase phosphate triester technology. The rate of cleavage from the succinyl linkage comm
Publikováno v:
Nucleic Acids Research. 8:4575-4592
Two dodecadeoxynucleotides of defined sequence have been synthesised by phosphotriester methodology. They can be polymerised to give a double stranded DNA which codes, when read in the correct phase, for the repeating dipeptide poly(aspartyl-phenylal
Autor:
J. Gunning, T.P. Patel, S.D. Cutbush, J. John Mann, T.A. Millican, M.A. Chauncey, M.A.W. Eaton, Stephen Neidle, G.A. Mock
Publikováno v:
Nucleic Acids Research. 12:7435-7453
The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-1-phenyl-beta-D-ribofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have
Autor:
David W. Hutchinson, M.A.W. Eaton
Publikováno v:
Tetrahedron Letters. 12:1337-1340
Autor:
David W. Hutchinson, M.A.W. Eaton
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 319:281-287
In an improved method for the synthesis of 5-hydroxycytidine diphosphate (ho5CDP), CDP is treated with bromine in the presence of 2,4,6-collidine and the products of the reaction purified by ion exchange chromatography. Polymerisation of ho5CDP by po
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 43:1988-1990
C 10 H 13 NO 3 cristallise dans le systeme orthorhombique avec le groupe d'espace P2 1 2 1 2 1 . Affinement de la structure jusqu'a 0,031
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 41:720-722
Mr=402.4, orthorhombic, P212~2 l, a= 4-946 (1), b= 15.887 (2), c=26.555 (2)A, V= 2086.7 (5) A 3, Z = 4, D x = 1.28 gcm -a, Cu Ka, 2 = 1.5418/k, B = 6.868 cm -1, F(000) = 848, T= 293 K, final R =0.054 for 648 observed reflections. The molecule is prop